S. Davis

Latest

• RARRES2 functions as a tumor suppressor by promoting $β$-catenin phosphorylation/degradation and inhibiting p38 phosphorylation in adrenocortical carcinoma
• Upregulation of IFN-Inducible and Damage-Response Pathways in Chronic Graft-versus-Host Disease
• Public data and open source tools for multi-assay genomic investigation of disease
• Whole Genome Sequencing of Newly Established Pancreatic Cancer Lines Identifies Novel Somatic Mutation (c.2587G>A) in Axon Guidance Receptor Plexin A1 as Enhancer of Proliferation and Invasion
• A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma
• Inhibition of Survivin with YM155 Induces Durable Tumor Response in Anaplastic Thyroid Cancer
• Dual inhibition of HDAC and EGFR signaling with CUDC-101 induces potent suppression of tumor growth and metastasis in anaplastic thyroid cancer
• Dual inhibition of HDAC and EGFR signaling with CUDC-101 induces potent suppression of tumor growth and metastasis in anaplastic thyroid cancer
• Integrated analysis of DNA methylation, immunohistochemistry and mRNA expression, data identifies a methylation expression index (MEI) robustly associated with survival of ER-positive breast cancer patients
• Orchestrating high-throughput genomic analysis with Bioconductor
• Antagonistic cross-regulation between Sox9 and Sox10 controls an anti-tumorigenic program in melanoma
• miR30a inhibits LOX expression and anaplastic thyroid cancer progression
• The Bioconductor channel in F1000Research
• Downregulation of IGFBP2 is associated with resistance to IGF1R therapy in rhabdomyosarcoma
• Lineage of origin in rhabdomyosarcoma informs pharmacological response
• Genome-wide methylation patterns in papillary thyroid cancer are distinct based on histological subtype and tumor genotype
• Prohibitin expression is associated with high grade breast cancer but is not a driver of amplification at 17q21.33
• Oncogenic ETS fusions deregulate E2F3 target genes in Ewing sarcoma and prostate cancer
• Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma
• Chromothripsis and focal copy number alterations determine poor outcome in malignant melanoma
• NCBI GEO: archive for functional genomics data sets--update
• Rb1 loss modifies but does not initiate alveolar rhabdomyosarcoma
• RCircos: an R package for Circos 2D track plots
• Whole genome and transcriptome sequencing of a B3 thymoma
• Exclusion of the 750-kb genetically unstable region at Xq27 as a candidate locus for prostate malignancy in HPCX1-linked families
• Advanced bone formation in mice with a dominant-negative mutation in the thyroid hormone receptor β gene due to activation of Wnt/β-catenin protein signaling
• In vivo role of alternative splicing and serine phosphorylation of the microphthalmia-associated transcription factor
• Comparative exome sequencing of metastatic lesions provides insights into the mutational progression of melanoma
• Genome-wide methylation profiling in archival formalin-fixed paraffin-embedded tissue samples
• A methyl-deviator epigenotype of estrogen receptor-positive breast carcinoma is associated with malignant biology
• Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening
• Exome sequencing identifies GRIN2A as frequently mutated in melanoma
• Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcoma
• Interferon-$γ$ links ultraviolet radiation to melanomagenesis in mice
• Preferential localization of human origins of DNA replication at the 5'-ends of expressed genes and at evolutionarily conserved DNA sequences
• Archival fine-needle aspiration cytopathology (FNAC) samples: untapped resource for clinical molecular profiling
• High frequencies of leukemia stem cells in poor-outcome childhood precursor-B acute lymphoblastic leukemias
• Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate
• Assessment of automated image analysis of breast cancer tissue microarrays for epidemiologic studies
• Chemical analysis of four capsules containing the controlled substance analogues 4-methylmethcathinone, 2-fluoromethamphetamine, alpha-phthalimidopropiophenone and N-ethylcathinone
• Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks
• Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis
• Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma
• Large-scale profiling of archival lymph nodes reveals pervasive remodeling of the follicular lymphoma methylome
• A molecular function map of Ewing's sarcoma
• Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression
• GEOmetadb: powerful alternative search engine for the Gene Expression Omnibus
• Molecular grading of ductal carcinoma in situ of the breast
• Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia
• Suppressor role of activating transcription factor 2 (ATF2) in skin cancer
• High-resolution mapping and characterization of open chromatin across the genome
• Constitutive Fms-like tyrosine kinase 3 activation results in specific changes in gene expression in myeloid leukaemic cells
• GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductor
• Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
• A single IGF1 allele is a major determinant of small size in dogs
• Detection of novel amplicons in prostate cancer by comprehensive genomic profiling of prostate cancer cell lines using oligonucleotide-based arrayCGH
• Zoom-in comparative genomic hybridisation arrays for the characterisation of variable breakpoint contiguous gene syndromes
• DNase-chip: a high-resolution method to identify DNase I hypersensitive sites using tiled microarrays
• Ewing's sarcoma: general insights from a rare model
• Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis
• Genome-wide mapping of DNase hypersensitive sites using massively parallel signature sequencing (MPSS)
• Statistics for ChIP-chip and DNase hypersensitivity experiments on NimbleGen arrays
• Gene expression profiling of human sarcomas: insights into sarcoma biology
• BioMart and Bioconductor: a powerful link between biological databases and microarray data analysis
• Database of mRNA gene expression profiles of multiple human organs
• Impact of overlapping recruitment on linkage analysis of complex disorders: simulation studies
• Linkage and association between inflammatory bowel disease and a locus on chromosome 12
• Comparison of nonparametric statistics for detection of linkage in nuclear families: single-marker evaluation
• Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10
• Analysis of a complex oligogenic disease
• Analysis of bipolar disorder using affected relatives
• Nonparametric simulation based linkage statistics for general pedigrees
• Nonparametric simulation-based statistics for detecting linkage in general pedigrees