P. S. Meltzer

Latest

• Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant
• caOmicsV: an R package for visualizing multidimensional cancer genomic data
• Whole Genome Sequencing of Newly Established Pancreatic Cancer Lines Identifies Novel Somatic Mutation (c.2587G>A) in Axon Guidance Receptor Plexin A1 as Enhancer of Proliferation and Invasion
• A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma
• Downregulation of IGFBP2 is associated with resistance to IGF1R therapy in rhabdomyosarcoma
• Lineage of origin in rhabdomyosarcoma informs pharmacological response
• Genome-wide methylation patterns in papillary thyroid cancer are distinct based on histological subtype and tumor genotype
• High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias
• NCI-60 whole exome sequencing and pharmacological CellMiner analyses
• Prohibitin expression is associated with high grade breast cancer but is not a driver of amplification at 17q21.33
• A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway
• Oncogenic ETS fusions deregulate E2F3 target genes in Ewing sarcoma and prostate cancer
• The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology
• Chromothripsis and focal copy number alterations determine poor outcome in malignant melanoma
• Rb1 loss modifies but does not initiate alveolar rhabdomyosarcoma
• SRAdb: query and use public next-generation sequencing data from within R
• Exclusion of the 750-kb genetically unstable region at Xq27 as a candidate locus for prostate malignancy in HPCX1-linked families
• Advanced bone formation in mice with a dominant-negative mutation in the thyroid hormone receptor β gene due to activation of Wnt/β-catenin protein signaling
• CHEK2 genomic and proteomic analyses reveal genetic inactivation or endogenous activation across the 60 cell lines of the US National Cancer Institute
• Comparative exome sequencing of metastatic lesions provides insights into the mutational progression of melanoma
• Genome-wide methylation profiling in archival formalin-fixed paraffin-embedded tissue samples
• Genome-wide depletion of replication initiation events in highly transcribed regions
• A methyl-deviator epigenotype of estrogen receptor-positive breast carcinoma is associated with malignant biology
• Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcoma
• Interferon-$γ$ links ultraviolet radiation to melanomagenesis in mice
• Preferential localization of human origins of DNA replication at the 5'-ends of expressed genes and at evolutionarily conserved DNA sequences
• Archival fine-needle aspiration cytopathology (FNAC) samples: untapped resource for clinical molecular profiling
• High frequencies of leukemia stem cells in poor-outcome childhood precursor-B acute lymphoblastic leukemias
• Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks
• Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis
• Kinetic complexity of the global response to glucocorticoid receptor action
• Large-scale profiling of archival lymph nodes reveals pervasive remodeling of the follicular lymphoma methylome
• TRAIL induces apoptosis in triple-negative breast cancer cells with a mesenchymal phenotype
• GEOmetadb: powerful alternative search engine for the Gene Expression Omnibus
• Molecular grading of ductal carcinoma in situ of the breast
• Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia
• Interaction of the glucocorticoid receptor with the chromatin landscape
• GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductor
• Modeling synovial sarcoma: timing is everything
• Zoom-in comparative genomic hybridisation arrays for the characterisation of variable breakpoint contiguous gene syndromes
• DNase-chip: a high-resolution method to identify DNase I hypersensitive sites using tiled microarrays
• Ewing's sarcoma: general insights from a rare model
• Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis
• Gene expression profiling of human sarcomas: insights into sarcoma biology