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This function searchs [GDS](https://www.ncbi.nlm.nih.gov/gds) database, and return a data.frame for all the search results.

Usage

searchGEO(query, step = 500L)

Arguments

query

character, the search term. The NCBI uses a search term syntax which can be associated with a specific search field with square brackets. So, for instance "Homo sapiens\[ORGN\]" denotes a search for `Homo sapiens` in the “Organism” field. Details see <https://www.ncbi.nlm.nih.gov/geo/info/qqtutorial.html>. The names and definitions of these fields can be identified using [entrez_db_searchable][rentrez::entrez_db_searchable].

step

the number of records to fetch from the database each time. You may choose a smaller value if failed.

Value

a data.frame contains the search results

Details

The NCBI allows users to access more records (10 per second) if they register for and use an API key. [set_entrez_key][rentrez::set_entrez_key] function allows users to set this key for all calls to rentrez functions during a particular R session. You can also set an environment variable `ENTREZ_KEY` by [Sys.setenv][base::Sys.setenv]. Once this value is set to your key rentrez will use it for all requests to the NCBI. Details see <https://docs.ropensci.org/rentrez/articles/rentrez_tutorial.html#rate-limiting-and-api-keys>

Examples

GEOquery::searchGEO("diabetes[ALL] AND Homo sapiens[ORGN] AND GSE[ETYP]")
#>                                                                                                                                                                                                                                                         Title
#> 1                                                                              Shifts in the Immunoepigenomic Landscape of Monocytes in Response to a Diabetes-Specific Social Support Intervention: A Pilot Study Among Native Hawaiian Adults with Diabetes
#> 2                                                                                                                                                                                                     Vitreous of proliferative diabetic retinopathy patients
#> 3                                                                                                                                 Circulating small non-coding RNA profiling as potential biomarkers of atherosclerotic plaque composition in Type 1 diabetes
#> 4                                                                                                                                                    Independent phenotypic plasticity axes define mammalian metabolic and obesity sub-types [RNA-seq, human]
#> 5                                                                                                                                                                 Transcriptional regulation of liver lipotoxicity in non-alcoholic steatohepatitis [RNA-seq]
#> 6                                                                                                                                                                Transcriptional regulation of liver lipotoxicity in non-alcoholic steatohepatitis [ATAC-seq]
#> 7                                                                                                                                 Distinctive exercise-induced inflammatory response and exerkine induction in skeletal muscle of people with type 2 diabetes
#> 8                                                                                                                         Bioinformatic analysis of the mechanism by which metformin enhances chemosensitivity of head and neck squamous cell carcinoma cells
#> 9                                                                                                                                                    Glucagon-like Peptide-1 (GLP-1) Rescue Diabetic Cardiac Dysfuntions in Human iPSC-Derived Cardiomyocytes
#> 10                                                                                                                                                          DNA Methylation Profiling Reveals Novel Pathway Implicated in Cardiovascular Diseases of Diabetes
#> 11                                                                                                                                     Transcriptome analysis of Newly Diagnosed Type 2 Diabetes Subjects identifies genes to predict Metformin drug Response
#> 12                                                                                                                Hepatic senescence is associated with clinical progression of NAFLD/NASH: Role of BMP4 and its antagonist Gremlin1 (Visceral adipose cells)
#> 13                                                                                                                                                                                             Single-cell Transcriptome Atlas of the Human Corpus Cavernosum
#> 14                                                                                                                       Genome-wide placental gene methylations in gestational diabetes mellitus, fetal growth and metabolic health biomarkers in cord blood
#> 15                                                                                                                                                              Development of a physiological insulin resistance model in human stem cell-derived adipocytes
#> 16                                                                                                                                                                  Bulk RNA-seq on mouse model of diabetic nephropathy and in vitro model of SRSF7 knockdown
#> 17                                                                                                                         Altered expressions of transfer RNA-derived small RNAs and microRNAs in the vitreous humour of proliferative diabetic retinopathy.
#> 18                                                                                                                                                              Synovial inflammatory pathways characterize anti-TNF-responsive rheumatoid arthritis patients
#> 19                                                                                      Self-amplifying Loop of NF-κB and Periostin Initiated by PIEZO1 Accelerates Mechano-induced Senescence of Nucleus Pulposus Cells and Intervertebral Disc Degeneration
#> 20                                                                                                                                                                                        Patient iPSCs with NEUROG3 mutation reveal pancreatic insufficiency
#> 21                                                                                                                                                                                                     Gene expression data from human omental adipose tissue
#> 22                                                                                                                                               Expression profiles of placenta and umbilical cord blood with or without gestational diabetes mellitus (GDM)
#> 23                                                                                           Reduced representation bisulfite sequencing (RRBS) methylation profiles of placenta and umbilical cord blood with or without gestational diabetes mellitus (GDM)
#> 24                                                                                                              Methylation profiling (RRBS) and expression profiling (RNA-seq) of placenta and umbilical cord blood with gestational diabetes mellitus (GDM)
#> 25                                                                                                                                                     Deciphering protective mechanism against human type 2 diabetes through in vitro β cell differentiation
#> 26                                                                                                                                                                              High-throughput analysis of ANRIL circRNA isoforms in human pancreatic islets
#> 27                                                        LncRNA LYPLAL1-DT screening from type 2 diabetes with macrovascular complication contributes protective effects on human umbilical vein endothelial cells via regulating the miR-204-5p/SIRT1 axis.
#> 28                                                                                                                                                                                     DNA Methylation-Based Prediction of Post-Operative Atrial Fibrillation
#> 29                                                                                                                                                                                  DNA Methylation-Based Prediction of Post-Operative Atrial Fibrillation II
#> 30                                                                                                                                                                                   DNA Methylation-Based Prediction of Post-Operative Atrial Fibrillation I
#> 31                                                                                                                          RNA-seq profiling of tubulointerstitial tissue reveals a potential therapeutic role of dual anti-phosphatase 1 in kidney diseases
#> 32                                                                                                                                              Bone metabolism-related serum miRNAs to diagnose postmenopausal osteoporosis in middle-aged and elderly women
#> 33                                                                                                                                                           Transcription Factor Binding Analysis of Wild Type and HHEX-/- ES-derived Pancreatic Progentiors
#> 34                                                                                                                                                                    Chromatin Landscape Analysis of Wild Type and HHEX-/- ES-derived Pancreatic Progentiors
#> 35                                                                                                                                                                Transcription Landscape Analysis of Wild Type and HHEX-/- ES-derived Pancreatic Progentiors
#> 36                                                                                                                                                                                     Effect of O-GlcNAc Transferase (OGT) siRNA in trophoblastic BeWo cells
#> 37                                                                                                                                                        Polysome profiling quantified by RNA sequencing in PANC1 cells treated with MNK2 inhibitors or DMSO
#> 38                                                                                                                                       Circulating extracellular vesicles exhibit a differential miRNA profile in gestational diabetes mellitus pregnancies
#> 39                                                                                                                                          Serum miRNA profile in diabetic patients with ischemic heart disease (IHD) as a promising non-invasive biomarker.
#> 40                                                                                                                                                        Identification of significant immune-related genes for diabetic foot ulcers: validated by scRNA-seq
#> 41                                                                                                                              Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells
#> 42                                                                                                                                                            Genome-wide Analysis Reflects Novel 5-Hydroxymethylcytosines Implicated in Diabetic Nephropathy
#> 43                                  Transcriptome analysis and weighted gene co-expression network reveal candidate genes and pathways responses to lactate dehydrogenase inhibition (oxamate) in hyperglycemic human renal proximal epithelial tubular cells
#> 44                                                                                                                                                   Fourteen-weeks combined exercise epigenetically modulated 118 genes of menopausal women with prediabetes
#> 45                                                                                                                                                                       Human placental tissues:control group vs non-diabetic fetal macrosomia (NDFMS) group
#> 46                                                                                                             Multi-dimensional modeling disrupted synapse formation underlying psychiatric disorders of Wolfram syndrome reveals essentiality of astrocytes
#> 47                                                                                                                           Transcriptional and chromatin accessibility changes underlying progression from islet autoantibody positivity to type 1 diabetes
#> 48                                                                                                                                                       Transcriptional changes underlying progression from islet autoantibody positivity to type 1 diabetes
#> 49                                                                                                                                               Chromatin accessibility changes underlying progression from islet autoantibody positivity to type 1 diabetes
#> 50                                                                                                                                                                                    In-depth molecular profiling specifies human retinal microglia identity
#> 51                                                                                                                                                                   Probiotic normalization of systemic inflammation in siblings of Type 1 diabetes patients
#> 52                                                                                                                                          Characterization of peripheral blood TCR in patients with Type 1 Diabetes Mellitus by BD Rhapsody™ VDJ CDR3 Assay
#> 53                                                                                         Diverging metabolic effects of two energy restricted diets differing in nutrient quality: a 12-week randomized controlled trial in subjects with abdominal obesity
#> 54                                                                                         RNA aptamers specific for transmembrane p24 trafficking protein 6 and Clusterin for the targeted delivery of imaging reagents and RNA therapeutic to human β cells
#> 55                                                                                                                                             Bariatric surgery mediated weight loss reduces breast cancer risk by reducing estrogen receptor alpha activity
#> 56                                                                                                                                              RNA-seq profiles between human parental and 5-FU drug resistant HCT116 and SW480 colorectal cancer cell lines
#> 57                                                                             Identification of Key LncRNAs and Pathways in Prediabetes and Type 2 Diabetes Mellitus for Hypertriglyceridemia Patients Based on Weighted Gene Co-Expression Network Analysis
#> 58                                                                                                                                                                                    Increased insulin secretion in ZNT8 mutant stem-cell derived beta cells
#> 59                                                                                                                         Differentially-expressed mRNAs, microRNAs and long noncoding RNAs in intervertebral disc degeneration identified by RNA-sequencing
#> 60                                                                                                                                                Human Tubular Epithelial Cells Activate a Coordinated Stress Response after Serum Exposure [RNAseq-pid2019]
#> 61                                                                                                                                                Human Tubular Epithelial Cells Activate a Coordinated Stress Response after Serum Exposure [RNAseq-pid1830]
#> 62                                                                                                                            VPA-treatment of Panc-1-cells to study epigenetic impact mediated by histone acetylation on epithelial-mesenchymal transmission
#> 63                                                                                                                                                                        Human Pluripotent Stem Cell-derived Islets Ameliorate Diabetes in Nonhuman Primates
#> 64                                                                                                                                                     Human Pluripotent Stem Cell-derived Islets Ameliorate Diabetes in Nonhuman Primates [human_singlecell]
#> 65                                                                                                                                                           Human Pluripotent Stem Cell-derived Islets Ameliorate Diabetes in Nonhuman Primates [human_bulk]
#> 66                                                                                                                                                                                             RNA-seq of human adipose tissue macrophage subtypes in obesity
#> 67                                                                                                                                                                       Genome-wide DNA methylation profiling in anorexia nervosa discordant identical twins
#> 68                                                                                        Loci-specific differences in blood DNA methylation in HBV-negative populations at risk for hepatocellular carcinoma development - post-diagnostic HCC blood samples
#> 69                                                                                         Loci-specific differences in blood DNA methylation in HBV-negative populations at risk for hepatocellular carcinoma development - pre-diagnostic HCC blood samples
#> 70                                                                                                                                                         MYCL-mediated in vivo reprogramming expands pancreatic insulin-producing cells to reverse diabetes
#> 71                                                                                  Single-cell RNA-sequencing reveals the heterogeneity of microglia in fibrous membrane derived from proliferative diabetic retinopathy and proliferative vitreoretinopathy
#> 72                                                                                                                                             HAMSAB supplement enhances SCFA production associated with microbiota and immune modulation in type 1 diabetes
#> 73                                                                                                      An HNF1A truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonising HNF1B function
#> 74                                                                                                                                                                                         Limited extent and consequences of pancreatic SARS-CoV-2 infection
#> 75                                                                                                                                Exosomal RNA expression profiles and their prediction performance in gestational diabetes mellitus patients with macrosomia
#> 76                                                                                                                                                                                                                   circRNA profiles of diabetic retinopathy
#> 77                                                                                                                    A global analysis on the differential regulation of RNA binding proteins (RBPs) by TNF–α as potential modulators of metabolic syndromes
#> 78                                                                                                          RNA sequencing of control and PTPN2 knocked down transcriptomes in EndoC-    H1 cells with or without the treatment of pro-inflammatory cytokines
#> 79                                                                                                                                         Pharmacologically enhanced regulatory hematopoietic stem cells (HSC.Regs) reverts experimental autoimmune diabetes
#> 80                                                                                                                                                  A miR-125 / Sirtuin-7 pathway drives pro-calcific potential of myeloid cells in diabetic vascular disease
#> 81                                                                                                                     Exploring the mechanism of Jiangtang Tiaozhi Recipe in the treatment of obese T2DM patients with dyslipidemia based on transcriptomics
#> 82                                                                                                                                                                                                                A single cell atlas of human adipose tissue
#> 83                                                                                                                                                         Characterization of the stromal vascular fraction (SVF) of human subcutaneous adipose tissue (SAT)
#> 84                                                                                                                                                                                           Epigenomic and Transcriptional Basis of Human Insulin Resistance
#> 85                                                                                                                            Prevalence of inflammatory pathways over immuno-tolerance in peripheral blood mononuclear cells of recent-onset type 1 diabetes
#> 86                                                                                                                                                               Inflammatory pathways in peripheral blood expression profile of recent-onset type 1 diabetes
#> 87                                                                                                                                 Integrated analysis of the transcriptome-wide m6A methylome in gestational diabetes mellitus and healthy control placentas
#> 88                                                                                                                                                                          RNA sequence of gestational diabetes mellitus (GDM) and healthy control placentas
#> 89                                                                                                                     Integrated analysis of the transcriptome-wide m6A methylome in gestational diabetes mellitus and healthy control placentas [meRIP-seq]
#> 90                                                                                                                                                                                        HO1 activates autophagy to protect intervertebral disc degeneration
#> 91                                                                                                                                                             Heterogeneous Gene Expression Patterns of Tuberculosis-Diabetes Interaction in Diverse Cohorts
#> 92                                                                                                                                                              Epigenetic alterations are associated with gastric emptying disturbances in Diabetes Mellitus
#> 93                                                                              Integratome analysis of adipose tissues reveals abnormal epigenetic regulation of adipogenesis, inflammation, and insulin signaling in obese individuals with type 2 diabetes
#> 94                                                                         Whole Transcriptomic analysis of placenta and its released extracellular vesicles in normal and preeclampsia pregnancies: insigths into novel biomarkers and mechanisms of disease
#> 95                                                                                     SmallRNA analysis of placenta and its released extracellular vesicles in normal and preeclampsia pregnancies: insigths into novel biomarkers and mechanisms of disease
#> 96                                                                               Transcriptomic analysis of placenta and its released extracellular vesicles in normal and preeclampsia pregnancies: insigths into novel biomarkers and mechanisms of disease
#> 97                                                                                                                                         Persistent Coxsackievirus B1 infection results in extensive changes in the transcriptome of a pancreatic cell line
#> 98                                                                                                                                                           Germline-like TCR alpha chains dominate shared self-reactive T cell receptors in type 1 diabetes
#> 99                                                                                            Human Tongue Fungiform Papilla Transcriptome and Proteome Reveal Sex Differences in Long Intergenic Noncoding RNA, Immune Response and Metabolism Genes [array]
#> 100                                                                                                                                                  DNA methylation profiling of cord blood progenitor endothelial cells from overweight and GDM pregnancies
#> 101                                                                                                                                                       Single cell trajectory modeling identifies a primitive trophoblast state defined by BCAM enrichment
#> 102                                                                                                                     TGF-β-induced miR143/145 influences differentiation, insulin signaling and exercise response in human skeletal muscle [small RNA-seq]
#> 103                                                                                                                           TGF-β-induced miR143/145 influences differentiation, insulin signaling and exercise response in human skeletal muscle [RNA-seq]
#> 104                                                                                                                                 LncRNA expression profile and target gene prediction of calcification in human aortic smooth muscle cells induced by DPP4
#> 105                                                                                                                                                                  Abnormal exocrine-endocrine cell crosstalk promotes β-cell dysfunction and loss in MODY8
#> 106                                                                                                                              Exploratory study reveals far reaching systemic and cellular effects of verapamil treatment in subjects with type 1 diabetes
#> 107                                                                                                                                                    Changes in CIDEA expression associate with adipocytes size and functionality in adolescent obese girls
#> 108                                                                                                                                                 A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases
#> 109                                                                                                                          A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases [study of 13 diseases]
#> 110                                                                                                                                                                            Effect of salivary exosomal miR-25-3p on periodontitis with insulin resistance
#> 111                                                                                                                                               Alterations of 5-Hydroxymethylcytosines in Circulating Cell-free DNA Reflect Retinopathy in Type 2 Diabetes
#> 112                                                                   Adipocyte Precursor Cells from First Degree Relatives of type 2 diabetic patients feature changes of hsa-mir-23a-5p, -193a-5p, and -193b-5p and Insulin-Like Growth Factor 2 expression
#> 113                                                    Adipocyte Precursor Cells from First Degree Relatives of type 2 diabetic patients feature changes of hsa-mir-23a-5p, -193a-5p, and -193b-5p and Insulin-Like Growth Factor 2 expression [smallRNA-seq]
#> 114                                                         Adipocyte Precursor Cells from First Degree Relatives of type 2 diabetic patients feature changes of hsa-mir-23a-5p, -193a-5p, and -193b-5p and Insulin-Like Growth Factor 2 expression [RNA-Seq]
#> 115                                                                                                                                                                  Transcriptome dataset of two different adipose tissues in gestational diabetes patients.
#> 116                                                                              Gene-expression profiles of whole blood cells from a Han Chinese population with or without Type-2 Diabetes Mellitus or/and its complications in nephropathy and retinopathy
#> 117                                                                                                                                                                              RNAsequencing of control and STAT3 knocked down transriptomes of EndoC cells
#> 118                                                                                                                                                                                                                              Perturb-Seq using T2D islets
#> 119                                                                                                                                                                                                                                 scGOF-Seq using ND islets
#> 120                                                                                                                                                                                        BACH2 inhibition reverses β-cell failure in type 2 diabetes models
#> 121                                                                                                                                                       Isoforms of SEMA3E-containing supernatant treated gene expression in human aortic endothelial cells
#> 122                                                                                                                                                                                              Single Cell Transcriptomic Landscape of Diabetic Foot Ulcers
#> 123                                                                                  In-depth molecular characterization of neovascular membranes suggests a role for hyalocytes-to-myofibroblasts transdifferentiation in proliferative diabetic retinopathy
#> 124                                                                                                                                                                     Impaired Skeletal Muscle Repair in Healthy Young Adults with Type 1 Diabetes Mellitus
#> 125                                                                                                                                                                                   Spatial transcriptomics of healing and non-healing diabetic foot ulcers
#> 126                                                                                                                                                             Adipocyte-derived extracellular vesicles promote breast cancer progression in type 2 diabetes
#> 127                                                                                 Dysregulated lncRNA and mRNA may promote the progression of ischemic stroke via immune and inflammatory pathways: results from RNA sequencing and bioinformatics analysis
#> 128                                                                                                                                                   Lnc-SLC15A1-1 Up-regulates CXCL10/CXCL8 Expression in Endothelial Cells by Sponging MicroRNAs (RNA-Seq)
#> 129                                                                                                                                                                       Distinct hepatic gene expression patterns characterize progressive disease in NAFLD
#> 130                                                                                                                                           Transcriptome-wide N6-methyladenine profiling in low input multiplex samples by a kit-free multi-barcode method
#> 131                                                                                                                                                                      ENTPD3 Marks Mature Stem Cell Derived Beta Cells Formed by Self-Aggregation in Vitro
#> 132                                                                                                                                                        RNA-seq analysis for wild-type fibroblasts and patient fibroblasts bearing the m.3243A>G mutatioin
#> 133                                                                                            Progressive ER stress over time due to human insulin gene mutation contributes to pancreatic β-cell dysfunction, islet inflammation and compensatory responses
#> 134                                                                                                                                                                                            Altered Human Alveolar Bone Gene Expression in Type 2 Diabetes
#> 135                                                                                                                                           Impaired bone fracture healing in type 2 diabetes is caused by defective functions of skeletal progenitor cells
#> 136                                                                                                                                    Increased adipose tissue fibrogenesis, not impaired expandability, is associated with nonalcoholic fatty liver disease
#> 137                                                                                                                                                                                   Role of microRNA-143, -150 and 126 in pathological retinal angiogenesis
#> 138                                                                                                            10X genomics single cell GEX and VDJ 5' sequencing of PBMC from Type 1 Diabetes patients treated with Treg therapy alone or plus low dose IL-2
#> 139                                                                                                                         Early developmental alteration of neurite outgrowth occurs besides late-appearing neurodegenerative processes in Wolfram syndrome
#> 140                                                                                                                                                           Transcriptome analysis of human pancreatic preadipocytes and in vitro differentiated adipocytes
#> 141                                                                                                                     Novel diabetes gene discovery through comprehensive characterization and integrative analysis of longitudinal gene expression changes
#> 142                                                                                                                                                              Lipid droplets protect human β-cells from lipotoxic-induced stress and cell identity changes
#> 143                                                                                                                                                                          Acetylation State of Histone Core Defines Macrophage Dynamics in Diabetic Wounds
#> 144                                                                                                                                     Permutational immune analysis reveals architectural similarities between inflammaging, Down syndrome and autoimmunity
#> 145                                                                                                                                                       Combinatorial transcription factor profiles predict mature and functional human islet α and β cells
#> 146                                                                                                                                              Heme-Oxygenase 1 is a Master Regulator of Cell Fate Following Oxidative Stress Response in Endothelial Cells
#> 147                                                                           ATAC-seq and multi-omics analysis of human liver highlight a hepatocyte-specific enhancer for ACOT1 regulating the balance of acyl-CoA and free fatty acids in type 2 diabetes.
#> 148                                                                                                                             Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models
#> 149                                                                                                             Epigenetic impairment and blunted transcriptional response to Mycobacterium tuberculosis of alveolar macrophages from persons living with HIV
#> 150                                                                                                   Epigenetic impairment and blunted transcriptional response to Mycobacterium tuberculosis of alveolar macrophages from persons living with HIV (RNA-Seq)
#> 151                                                                                                  Epigenetic impairment and blunted transcriptional response to Mycobacterium tuberculosis of alveolar macrophages from persons living with HIV (ATAC-Seq)
#> 152                                                                                                                                                                           Circulating circRNA signature in pregnancies with gestational diabetes mellitus
#> 153                                                                                                                      High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control
#> 154                                                                                                      mRNA-seq read counts of peripheral blood mononuclear cells from congenital generalized lipodystrophy patients and their gender/aged-matched controls
#> 155                                                                                                                            Disrupted Circadian Oscillations in Type 2 Diabetes are Linked to Altered Rhythmic Mitochondrial Metabolism in Skeletal Muscle
#> 156                                                                                                               Disrupted Circadian Oscillations in Type 2 Diabetes are Linked to Altered Rhythmic Mitochondrial Metabolism in Skeletal Muscle [Affymetrix]
#> 157                                                                                                                  Disrupted Circadian Oscillations in Type 2 Diabetes are Linked to Altered Rhythmic Mitochondrial Metabolism in Skeletal Muscle [RNA-seq]
#> 158                                                                                                                                                       Identification of circulating miRNA molecular signature for erectile dysfunction in type 2 diabetes
#> 159                                                                                                                                                High resolution chromosome conformation capture from gene promoters at COVID-19, T1D, AS and RBC GWAS loci
#> 160                                                                                                                                          Angiogenin Released from ABCB5+ Stromal Precursors Improves Healing of Diabetic Wounds by Promoting Angiogenesis
#> 161                                                                                                                                                                   A Critical Role of Hepatic GABA in The Metabolic Dysfunction and Hyperphagia of Obesity
#> 162                                                                                                                                                                   Islet Sympathetic Innervation and Islet Neuropathology in Patients with Type 1 Diabetes
#> 163                                                                                                                                          Gene expression signatures for human non-diabetic (hND) islets and human type 2 diabetes mellitus (hT2DM) islets
#> 164                                                                                                                                      RNA-seq analysis with isolated human pancreatic islets treated with human breast cancer cell secreted Evs or control
#> 165                                                                                                                 Modelling HNF1B-associated monogenic diabetes using human iPSCs reveals an early stage impairment of the pancreatic developmental program
#> 166                                                                                                                                             TCF7L2 lncRNA: A Link between Bipolar Disorder and Body Mass Index through Glucocorticoid Signaling [RNA-Seq]
#> 167                                                                                                                                            TCF7L2 lncRNA: A Link between Bipolar Disorder and Body Mass Index through Glucocorticoid Signaling [ChIP-Seq]
#> 168                                                                                                                                                                       Serum miRNA profiling for early PDAC diagnosis and prognosis: a retrospective study
#> 169                                                                                                                                                                                                     Transcriptomic phenotyping of human labor myometrium.
#> 170                                                                                                                                                            RNA Sequencing of Blood in Coronary Artery Disease; Involvement of Regulatory T Cell Imbalance
#> 171                                                                                                                                         RNA Sequencing of Blood in Coronary Artery Disease; Involvement of Regulatory T Cell Imbalance [Discovery Cohort]
#> 172                                                                                                                                            Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets
#> 173                                                                                                                                           Effects of oral-glucose load on the gene expression of peripheral blood mono-nuclear cells in Asian-Indian men.
#> 174                                                                                                                   Genetic variants associated with development of colorectal cancer, type 1 diabetes, Hodgkin lymphoma and  Diffuse large B-cell lymphoma
#> 175                                                                                                                                                                            Self-Renewing Tri-Potent Stem/Progenitor-like Cells from Adult Human Pancreas 
#> 176                                                                                                Areca catechu-(Betel-nut)-induced whole transcriptome changes in a human monocyte cell line that may have relevance to diabetes and obesity; a pilot study
#> 177                                                                                                                                                                                            Generation of Human Islet Cell-Type-Specific Identity Genesets
#> 178                                                                                                                                                                 Identification of potential genomic alterations in primary and recurrent synovial sarcoma
#> 179                                                                                                                                                                  Transcriptome sequencing in serum exosomes from proliferative diabetic retinopathy (PDR)
#> 180                                                                                                                                   RECK isoforms are differentially expressed in patients with stable and unstable coronary artery disease: A pilot study.
#> 181                                                                                      Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits [snRNA-seq]
#> 182                                                                                     Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits [snATAC-seq]
#> 183                                                                                                                                                                          Profiling of CD14+ monocytes from humans with Type diabetes and without diabetes
#> 184                                                                                                                                                              Profiling of CD14+ monocytes from humans with Type diabetes and without diabetes [CHIRP-seq]
#> 185                                                                                                                                                                Profiling of CD14+ monocytes from humans with Type diabetes and without diabetes [RNA-Seq]
#> 186                                                                                                                                                                                  Genome wide methylation of cord blood from gestational diabetes mellitus
#> 187                                                                                                                                                                         Modeling pancreatic beta cell senescence by induction of DNA double-strand breaks
#> 188                                                                                                                                                                                                            RNA-seq of HUVECs stimulated with HG and oxLDL
#> 189                                                                                                                                                     Pancreatic Differentiation of stem cells reveals pathogenesis of a syndrome of Ketosis-Prone Diabetes
#> 190                                                                                                                                                                                      The effect of homocysteine on Human Aortic Endothelial Cells [miRNA]
#> 191                                                                                                                                                                                        The effect of homocysteine on Human Aortic Endothelial Cells [RNA]
#> 192                                                                                                                                                   Circulating exosomal miRNA signature in pregnancies with gestational diabetes mellitus across gestation
#> 193                                                                                                                            RNA Sequencing Facilitates Quantitative Analysis of Transcriptomes of adipose stem cells from diabetic, old and young patients
#> 194                                                                                                                          DNA methylation in skeletal muscle of patients with hypertension and diabetes undergoing coronary artery bypass grafting surgery
#> 195                                                                                                                                                                      Muscle transcriptomic profiling of chronological aging and metabolic syndrome in men
#> 196                                                                                                                                                                   Single cell RNA-sequencing reveals placenta cellular heterogeneity in adverse pregnancy
#> 197                                                                                                                                                                Nicotinamide mononucleotide increases muscle insulin sensitivity in women with prediabetes
#> 198                                                                                                                                                                                                    scRNA-seq analysis of SARS-CoV-2 infected human islets
#> 199                                                                                                                                                       In-depth transcriptomic analyses investigating molecular mechanisms underlying diabetic retinopathy
#> 200                                                                                                                                            In-depth transcriptomic analyses investigating molecular mechanisms underlying diabetic retinopathy (smallRNA)
#> 201                                                                                                                                            In-depth transcriptomic analyses investigating molecular mechanisms underlying diabetic retinopathy (totalRNA)
#> 202                                                                                                                                                                                         An inter-dependent network of enhancers regulates INK4a/ARF locus
#> 203                                                                                                                         Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetes
#> 204                                                                                                                                              Temporal evolution of cellular heterogeneity during the progression to advanced, AR-negative prostate cancer
#> 205                                                                                                             Obese Insulin Resistant Humans with Compensatory Hyperinsulinemia Dissociate Lipolysis from Glycemia as Possible Adaptive Response to Fatness
#> 206                                      The effects of a novel oral nutritional supplement as compared to standard care on body composition, physical function and skeletal muscle mRNA expression in Dutch older adults with (or at risk of) undernutrition
#> 207                                                                                                                                                 Neonatal diabetes mutations disrupt a chromatin pioneering function that activates the human insulin gene
#> 208                                                                                                   Single-cell transcriptomic resolution of human pancreatic islets reveals cellular states and intercellular interactions associated with type 1 diabetes
#> 209                                                                                                                                                              Identification of human glucocorticoid response markers using integrated multi-omic analysis
#> 210                                                                                                                                             Identification of human glucocorticoid response markers using integrated multi-omic analysis [Adipose Tissue]
#> 211                                                                                                                         Identification of human glucocorticoid response markers using integrated multi-omic analysis [Peripheral blood mononuclear cells]
#> 212                                                                                                                                                        Expression data from peripheral blood mononuclear cells(PBMCs) in newly diagnosed type 2 diabetes
#> 213                                                                                                                   Unravelling the Biological Functions of Type 1 Diabetes Associated Noncoding Single-Nucleotide Polymorphism in Human Pancreatic β Cells
#> 214                                                                                                                                      Glucocorticoid signaling in pancreatic islets modulates gene regulatory programs and genetic risk of type 2 diabetes
#> 215                                                                                                              Human Placental Exosomes in Gestational Diabetes Mellitus Carry a Specific Set of miRNAs Associated with Skeletal Muscle Insulin Sensitivity
#> 216                                                                                                                     Unique human beta-cell senescence-associated secretory phenotype (SASP) reveal conserved signaling pathways and heterogeneous factors
#> 217                                                                                                                                                                               Interpreting type 1 diabetes risk with genetics and single cell epigenomics
#> 218                                                                               Transcriptional deregulation in subcutaneous adipose tissue from severely obese patients is associated with cancer: focus on gender differences and role of type 2 diabetes
#> 219                                                                                                                          ALTERED DUODENAL MUCOSAL MITOCHONDRIAL GENE EXPRESSION IS ASSOCIATED WITH DELAYED GASTRIC EMPTYING IN DIABETIC GASTROENTEROPATHY
#> 220                                                                                                              ALTERED DUODENAL MUCOSAL MITOCHONDRIAL GENE EXPRESSION IS ASSOCIATED WITH DELAYED GASTRIC EMPTYING IN DIABETIC GASTROENTEROPATHY [miRNA-Seq]
#> 221                                                                                                               ALTERED DUODENAL MUCOSAL MITOCHONDRIAL GENE EXPRESSION IS ASSOCIATED WITH DELAYED GASTRIC EMPTYING IN DIABETIC GASTROENTEROPATHY [mRNA-Seq]
#> 222                                                                                                                                              Population and single cell RNAseq analysis of CD4+ T cells in FOXP3 mutant mice ( scurfy") and IPEX patients
#> 223                                                                                                                                 Gene expression analysis of human mortal renal tubular epithelial cells chronically exposed to elevated levels of glucose
#> 224                                                                                                                                                                                         miRNA expression during BMSCs from human jaw in Type 2 diabetics.
#> 225                                                                                                                       Single-cell RNAseq (10x Genomics) analysis of human CD4+ T cells in IPEX patients, healthy donors and heterozygous mothers (blood).
#> 226                                                                                                                                                                  Impaired peripheral mononuclear cell metabolism in patients at risk of developing sepsis
#> 227                                                                                                                                                    A histological and transcriptional characterization of the pancreatic acinar tissue in type 1 diabetes
#> 228                                                                                                                                                                      Transcriptional analysis of islets of Langerhans from organ donors of different ages
#> 229                                                                                                                      Analysis of the transcriptome and DNA methylome in response to acute and recurrent low glucose in human primary astrocytes (RNA-Seq)
#> 230                                                                                                                     Analysis of the transcriptome and DNA methylome in response to acute and recurrent low glucose in human primary astrocytes (BeadChip)
#> 231                                                                                                                                        DNA methylation data throughout human muscle cell differentiation in individuals with type 2 diabetes and controls
#> 232                                                                                                                                                            DNA methylation data for human muscle cells from individuals with type 2 diabetes and controls
#> 233                                                                                                                                        mRNA expression data throughout human muscle cell differentiation in individuals with type 2 diabetes and controls
#> 234                                                                                                                                                            mRNA expression data for human muscle cells from individuals with type 2 diabetes and controls
#> 235                                                                                                           Integrative analysis of DNA methylation and gene expression data among preterm and/or small for gestational age infants during perinatal period
#> 236                                                                                             Integrative analysis of DNA methylation and gene expression data among preterm and/or small for gestational age infants during perinatal period [methylation]
#> 237                                                                                                                                                             Large-scale single-cell analysis reveals critical immune characteristics of COVID-19 patients
#> 238                                                                                                                                                                                   Urinary single cell profiling captures cellular diversity of the kidney
#> 239                                                                                                                                                                                                           SARS-CoV-2 infection of human pancreatic islets
#> 240                                                                                                                                             Transcriptomic characterization of the delayed wound healing response in a diabetic skin humanized mice model
#> 241                                                                                                                                                Exposure to Gestational Diabetes Mellitus In Utero Alters DNA Methylation in Placenta and Fetal Cord Blood
#> 242                                                                                                                                     Exposure to Gestational Diabetes Mellitus In Utero Alters DNA Methylation in Placenta and Fetal Cord Blood [Placenta]
#> 243                                                                                                                                        Exposure to Gestational Diabetes Mellitus In Utero Alters DNA Methylation in Placenta and Fetal Cord Blood  [Cord]
#> 244                                                                                                                                                      Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development
#> 245                                                                            Ayurvedic herbal preparation supplementation does not improve metabolic health in impaired glucose tolerance subjects; observations from a randomised placebo controlled trial
#> 246                                                                                                                 Single cell chromatin accessibility identifies pancreatic islet cell type- and state-specific regulatory programs of diabetes risk [Hi-C]
#> 247                                                                                                                        Single-cell chromatin accessibility identifies pancreatic islet cell type- and state-specific regulatory programs of diabetes risk
#> 248                                                                                                              Single-cell chromatin accessibility identifies pancreatic islet cell type- and state-specific regulatory programs of diabetes risk [RNA-seq]
#> 249                                                                                                           Single-cell chromatin accessibility identifies pancreatic islet cell type– and state-specific regulatory programs of diabetes risk [snATAC-seq]
#> 250                                                                                                    Type 2 Diabetes Mellitus is Associated with Transcriptome Alterations in Cortical Neurones and Associated Neurovascular Unit Cells in the Ageing Brain
#> 251                                                                                                                         Hyperglycemic memory of innate immune cells promotes in vitro proinflammatory responses of human monocytes and murine macrophages
#> 252                                                                                                                                        Expression profiles of human adipose tissue, adipocytes and stromal-vascular pellet cells from multiple body sites
#> 253                                                                                                                                                       miRNA sequencing profile of human plasma samples from healthy, diabetic, and gastroparesis patients
#> 254                                                                                                                                                                                                                 Pericardial fluid exosome miRNA profiling
#> 255                                                                                                                                                                                                         Long non-coding RNA screening for type 2 diabetes
#> 256                                                                                                                                                                      GLP-1 receptor signaling increases PCSK1 and beta-cell features in human alpha-cells
#> 257                                                                                                                       Distinct exhausted-like CD8 T cell populations are linked to C-peptide preservation in alefacept-treated, recent onset T1D subjects
#> 258                                                                                                                                                Identification of SRSF6 splicing regulatory map and its impact on diabetes susceptibility genes regulation
#> 259                                                                                                                                                                                Transcriptomic Signatures of Kidney Injury in Human Renal Biopsy Specimens
#> 260                                                                                                                                              The human aortic endothelium undergoes dose-dependent DNA methylation in response to transient hyperglycemia
#> 261                                                                                                                            Distinct exhausted CD8 T cell populations are linked to C-peptide preservation in alefacept-treated, recent onset T1D subjects
#> 262                                                                                                                                         Clinical, histopathologic and molecular features of idiopathic and diabetic nodular mesangial sclerosis in humans
#> 263                                                                                                                                                                                Array comparative genomic hybridization analysis of metastatic lung tumors
#> 264                                                                                                                                           Drug-drug interaction between metformin and sorafenib alters antitumor effect in hepatocellular carcinoma cells
#> 265                                                                                                  Estrogen-driven control of diabetogenic gene networks is associated with reduced levels of miR-224/452 circulating in extracellular vesicles [miRNA-Seq]
#> 266                                                                                                                                   The postprandial transcriptomic response of adipose tissue to high fat meals in middle-aged men with metabolic syndrome
#> 267                                                                                                                                                                                                      Human PBMCs: Healthy vs Diabetic nephropathy vs ESRD
#> 268                                                                                                                                                                              Multi-locus imprinting disturbances in a family harboring a ZFP57 truncation
#> 269                                                                                                                                                          Whole transcriptome sequencing of peripheral blood mononuclear cells from patients with COVID-19
#> 270                                                                                                                              Gene cascade analysis in human granulosa tumor cells (KGN) following exposure to high levels of free fatty acids and insulin
#> 271                                                                                                                                                                     Relationship between insulin sensitivity and gene expression in human skeletal muscle
#> 272                                                                                                                                                           Relationship between insulin sensitivity and gene expression in human skeletal muscle (Study B)
#> 273                                                                                                                                                           Relationship between insulin sensitivity and gene expression in human skeletal muscle (Study A)
#> 274                                                                                                                                                                     Identification of a human gut-derived LEAP2 fragment as a novel insulin secretagogue 
#> 275                                                                                                                                                                          RNA-seq of human dendritic cells cultured with PSAB-liposomes and/or Liraglutide
#> 276                                                                                                                                                                              Epigenome analysis of cord blood DNA from infants born into the UPBEAT study
#> 277                                                                                                                                Integrative omics analyses reveal epigenetic memory in diabetic cells regulating genes associated with kidney dysfunction.
#> 278                                                                                                                   Integrative omics analyses reveal epigenetic memory in diabetic cells regulating genes associated with kidney dysfunction. [sequencing]
#> 279                                                                                                                   Integrative omics analyses reveal epigenetic memory in diabetic cells regulating genes associated with kidney dysfunction. [microarray]
#> 280                                                                                                                                                                          Phospho-antibody microarray anayses for control and DG-LRG1 treated HUVEC cells.
#> 281                                                                                            Persistent or Transient Human β-cell Dysfunction Induced by Metabolic Stress Associated with Specific Signatures and Shared Gene Expression of Type 2 Diabetes
#> 282                                                                    Single-cell  analysis  of  adipose tissue  T cells in diabetic persons with HIV  reveals high proportions of clonally expanded CMV-like CD4+ T cells with cytotoxic RNA transcriptomes
#> 283                                                                                                                                                    Cell-free DNA Methylation and Transcriptomic Signature Prediction of Pregnancies with Adverse Outcomes
#> 284                                                                                                                                          Cell-free DNA Methylation and Transcriptomic Signature Prediction of Pregnancies with Adverse Outcomes [RNA-seq]
#> 285                                                                                                                                             Cell-free DNA Methylation and Transcriptomic Signature Prediction of Pregnancies with Adverse Outcomes [WGBS]
#> 286                                                                                                                Type 2 Diabetes reduces the enteroendocrine GLP-1 cell lineage in human obesity:  characterization in enriched human enteroendocrine cells
#> 287                                                                                                                                                                     A whole-genome CRISPRa screening metformin resistance related gene in prostate cancer
#> 288                                                                                                                                    A high glycemic burden drives functional and metabolic alterations of human monocytes in patients with type 1 diabetes
#> 289                                                                                                                                     Single cell transcriptomics of human islet ontogeny defines the molecular basis of beta cell dedifferentiation in T2D
#> 290                                                                                                                                                Single cell lineage analysis reveals cell fate determination events during directed β-cell differentiation
#> 291                                                                                                                                                                              RNAseq from human islets treated with brefeldin A as a model of Golgi stress
#> 292                                                                                                                                                                   Deregulated immune signature orchestrated by FOXM1 impairs human diabetic wound healing
#> 293                                                                                                                                                                                      Two distinct immunopathological profiles in lungs of lethal COVID-19
#> 294                                                                                                                               Baseline assessment of circulating microRNAs near diagnosis of type 1 diabetes predicts future stimulated insulin secretion
#> 295                                                                                                                      Liver-specific knockdown of class IIa HDACs has limited efficacy on glucose metabolism but entails severe organ side effects in mice
#> 296                                                                                                                                                                                                        Immune Gene Expression Profile of Tr1 Skewed Tregs
#> 297                                                                                             Transcriptomic analysis of peripheral blood mononuclear cells (PBMC) of patients with type 2 Diabetes Melittus(T2DM), Dyslipidemia (DL) and Periodontitis (P)
#> 298                                                                                                                                                                             Genomewide transcriptional analysis of growth hormone-treated human podocytes
#> 299                                                                                                                                                                 Differential effects of voclosporin and tacrolimus on insulin secretion from human islets
#> 300                                                                                                                                     Genome-Wide Profiling of DNA Methylation and Gene Expression Identifies Candidate Genes for Human Diabetic Neuropathy
#> 301                                                                                                                              Genome-Wide Profiling of DNA Methylation and Gene Expression Identifies Candidate Genes for Human Diabetic Neuropathy (RRBS)
#> 302                                                                                                                           Genome-Wide Profiling of DNA Methylation and Gene Expression Identifies Candidate Genes for Human Diabetic Neuropathy (RNA-Seq)
#> 303                                                                                                                                                              Comparison of Regulatory Type of Macrophages and PCMO Cells from perspective of RNAseq data.
#> 304                                                                                                                    Comparative transcriptome analysis of human skeletal muscle in response to cold acclimation and exercise training in human volunteers.
#> 305                                                                                                             Comparative transcriptome analysis of human skeletal muscle in response to cold acclimation and exercise training in human volunteers. [A391]
#> 306                                                                                                             Comparative transcriptome analysis of human skeletal muscle in response to cold acclimation and exercise training in human volunteers. [A294]
#> 307                                                                                                                                                      Stress-induced RNA–chromatin interactions promote endothelial dysfunction (scRNA-seq human vascular)
#> 308                                                                                                                                                                       Stress-induced RNA–chromatin interactions promote endothelial dysfunction (RNA-seq)
#> 309                                                                                                                                                            Stress-induced RNA–chromatin interactions promote endothelial dysfunction (iMARGI replicate 2)
#> 310                                                                                                                                                                                 Stress-induced RNA–chromatin interactions promote endothelial dysfunction
#> 311                                                                                                                                                                     Stress-induced RNA–chromatin interactions promote endothelial dysfunction (scRNA-seq)
#> 312                                                                                                                                                                        Stress-induced RNA–chromatin interactions promote endothelial dysfunction (iMARGI)
#> 313                                                                                                                                                                          Stress-induced RNA–chromatin interactions promote endothelial dysfunction (Hi-C)
#> 314                                                                                                                  Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity
#> 315                                                                                                                                                                                                                 Human pancreatic islets methylation array
#> 316                                                                                                                  Induced Expression of VEGFC, ANGPT, and EFNB2 and Their Receptors Characterizes Neovascularization in Proliferative Diabetic Retinopathy
#> 317                                                                                     DNA microarray analysis of blood before and after ingesting carotenoid-rich vegitable beverage for 8 weeks, a randomized and double-blinded controlled clinical trial
#> 318                                                                                                                                                                                                      Modeling human T-cell mediated beta cell destruction
#> 319                                                                                                                                                                                               The role of long noncoding RNAs during pancreas development
#> 320                                                                                                                                                             RNA-sequencing analysis of forearm skin in diabetic patients with or without foot ulcerations
#> 321                                                                                                                             Transcriptomic and Chromatin accessibility profiling of functional brown adipocytes derived from human pluripotent stem cells
#> 322                                                                                                                                The role of TCF7L2 rs290487 variant in hepatic glucose metabolism: an integrated analysis of clinical and multi-omics data
#> 323                                                                                               Increased long noncoding RNA maternally expressed gene 3 contributes to podocyte injury induced by high glucose through regulation of mitochondrial fission
#> 324                                                                                                                                   Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action
#> 325                                                                                                                                                                                     Derivation and Characterization of a UCP1 Reporter Human ES Cell Line
#> 326                                                                                                                                                          A common genetic trait through multistep hepatocarcinogenesis in a case with chronic hepatitis C
#> 327                                                                                                             Circulating miRNAs as a predictive biomarkers of progression from prediabetes to diabetes: outcomes of 5-year prospective observational study
#> 328                                                                                                                                        Vitamin C supplementation reduces expression of circulating miR-451a in poorly controlled type 2 diabetes mellitus
#> 329                                                                                                                               Expression data from of FACS separated acinar and duct cell at day 4 of suspension cultured human pancreatic exocrine cells
#> 330                                                                                                                                                       Expression data from day of isolation and day 4 suspension cultured human pancreatic exocrine cells
#> 331                                                                                                                                                                   Immune dysfunction in intermediate hyperglycaemia and diabetes patients in tuberculosis
#> 332                                                                                                                                                          Whole-blood transcriptome profiling reveals signatures of metformin and its therapeutic response
#> 333                                                                                                                                                                        Transcriptional Profiling of Normal, Stenotic, and Regurgitant Human Aortic Valves
#> 334                                                                                                                                                                                   Identified differentially expressed lncRNAs in type 2 diabetes patients
#> 335                                                                                                                                                              Unique molecular signatures of microRNAs in ocular fluids and plasma in diabetic retinopathy
#> 336                                                                                                                                            Differenatiation of ceRNA (circRNA, lncRNA and mRNA) expression  in PBMCs (peripheral blood mononuclear cells)
#> 337                                                                                                                                                                       Differenatiation of miRNA expression  in PBMCs (peripheral blood mononuclear cells)
#> 338                                                                                                                                         Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis
#> 339                                                                                                         RIPK1 gene variants associate with increased obesity in humans and can be therapeutically silenced to improve metabolic dysfunction in obese mice
#> 340                                                                                                                                                                                            MicroRNA arrays for early diagnosis of diabetic kidney disease
#> 341                                                                                                                                                   Epithelial membrane protein 2 (EMP2) regulates hypoxia induced angiogenesis in retinal epithelial cells
#> 342                                                                                                                                                                Successful Preclinical Islet Transplantation in the Subcutaneous Space for Type 1 Diabetes
#> 343                                                                                                                                                               Transimmunom whole blood RNA-seq data  from type 1 diabetic patients and healthy volunteers
#> 344                                                                                                                      The PPAR agonist Rosiglitazone induces paracrine signaling in melanoma cells that activate stromal cells and enhances tumor growth.
#> 345                                                                                                                                                            Innate immune stimulation of whole blood reveals IFN-1 hyper-responsiveness in type 1 diabetes
#> 346                                                                                          Gene expression profiles of human retinal microvascular pericytes (HRMVPC) and human lipoaspirate derived mesenchymal stromal cells (adipose stromal cells, ASC)
#> 347                                                                                                                                                        DNA methylation analysis of human peripheral blood mononuclear cell collected in the AIRWAVE study
#> 348                                                                                                                                                                               The omentum of obese girls harbors small adipocytes and browning transcrips
#> 349                                                                                                                                                                 Patient iPSCs identify vascular smooth muscle AADAC as protective against atherosclerosis
#> 350                                                                                                               Next generation sequencing identifies differentially expressed genes between breast cancer with diabetes and breast cancer without diabetes
#> 351                                                                                                                                                                                                                 Gestational diabetes and human amniocytes
#> 352                                                                                                                                                                         Transcriptomic changes in response to modulation of long-non-coding RNA LINC00473
#> 353                                                                                                                                            Single Cell Sequencing Analysis for Wolfram Syndrome (WS4) Unedited and Corrected Stem Cell-Derived Beta Cells
#> 354                                                                                                                                                                        Transcriptomic changes in response to modulation of long-non-coding RNA, LINC00473
#> 355                                                                                                                   An Exome-Wide Association Study Identifies New Susceptibility Loci for the Risk of Nicotine Dependence in European-American Populations
#> 356                                                                                                                 An integrated multi-omics approach identifies the landscape of interferon-a-mediated responses of human pancreatic beta cells [RNA-seq 2]
#> 357                                                                                                                  An integrated multi-omics approach identifies the landscape of interferon-a-mediated responses of human pancreatic beta cells [ATAC-seq]
#> 358                                                                                                                   An integrated multi-omics approach identifies the landscape of interferon-a-mediated responses of human pancreatic beta cells [RNA-seq]
#> 359                                                                                                                         Inhibition of Grb14, a negative modulator of insulin signaling,  improves glucose homeostasis without causing cardiac dysfunction
#> 360                                                                                                                    An Exome-Wide Association Study Identifies New Susceptibility Loci for the Risk of Nicotine Dependence in African-American Populations
#> 361                                                                                                                                           Beta cell-specific CD8+ T cells maintain stem-cell memory-associated epigenetic programs during type 1 diabetes
#> 362                                                                                                                              Beta cell-specific CD8+ T cells maintain stem-cell memory-associated epigenetic programs during type 1 diabetes (scATAC-seq)
#> 363                                                                                                                                    Beta cell-specific CD8+ T cells maintain stem-cell memory-associated epigenetic programs during type 1 diabetes (WGBS)
#> 364                                                                                                                          VEGF-B Signaling Impairs Endothelial Glucose Transcytosis via an LDLR-dependent Decrease in Membrane Cholesterol Loading [HBMEC]
#> 365                                                                                                              A long noncoding RNA, LOC157273, is the effector transcript at the chromosome 8p23.1-PPP1R3B metabolic traits and type 2 diabetes risk locus
#> 366                                                                                                                                                                                  Analysis of association between LPHN3 markers and substance use disorder
#> 367                                                                                                                          BET bromodomain containing epigenetic reader proteins regulate vascular smooth muscle cell proliferation and neointima formation
#> 368                                                                                                                                                Skeletal muscle enhancer interactions identify genes controlling whole body metabolism in humans [RNA-seq]
#> 369                                                                                                                                               Skeletal muscle enhancer interactions identify genes controlling whole body metabolism in humans [cHiC-seq]
#> 370                                                                                                                                               Skeletal muscle enhancer interactions identify genes controlling whole body metabolism in humans [ChIP-seq]
#> 371                                                                                                                                                    Single Cell RNA sequencing of MAFB +/+ and -/- cells at the pancreatic progenitor and beta-like stages
#> 372                                                                                                                                Differential DNA methylation encodes proliferation and senescence programs in human adipose-derived mesenchymal stem cells
#> 373                                                                                                                                                                                        A method for the generation of human stem cell-derived alpha cells
#> 374                                                                                                                                                                  Mendelian randomization identifies FLCN expression as a mediator of diabetic retinopathy
#> 375                                                                                                                                                                                          Longitudinal DNA methylation differences precede type 1 diabetes
#> 376                                                                                                                                      Interfering with DNA replication improves beta cell differentiation and maturation from human pluripotent stem cells
#> 377                                                                                                                                                                                 Transcriptional responses to TNF-alpha in germline A20 haploinsufficiency
#> 378                                                                                                                                                     Pancreas single cell patch-seq links physiologic dysfunction in diabetes to transcriptomic phenotypes
#> 379                                                                                                                                                                                            Molecular characterization of clonal human renal forming cells
#> 380                                                                                                     Sexually dimorphic methylation of CD3+ T-lymphocyte DNA in offspring of overweight and obese mothers in a high risk, minority population in the Bronx
#> 381                                                                                                                           Whole genome bisulfite sequencing of human spermatozoa reveals differentially methylated patterns from type 2 diabetic patients
#> 382                                                                                                                                                                            A composite immune signature parallels disease progression across T1D subjects
#> 383                                                                                                                                                      A composite immune signature parallels disease progression across T1D subjects (RNA-Seq Cohort 0 WB)
#> 384                                                                                                                                                    5-Hydroxymethylcytosines in Circulating Cell-free DNA Reveal Vascular Complications of Type 2 Diabetes
#> 385                                                                                                                                                                Genome Wide Analysis of Gene Expression Changes in Skin from Patients with Type 2 Diabetes
#> 386                                                                 Whole genome transcriptomics of pre-access veins and hemodialysis arteriovenous fistula (AVF) samples from two-stage AVF patients with different maturation outcomes (matured vs. failed)
#> 387                                                                                                                                                  Angiogenin derived from ABCB5+ mesenchymal stem cells improves diabetic wound via enhancing angiogenesis
#> 388                                                                                                     Vascular Progenitors Generated from Tankyrase Inhibitor-Regulated Naive Diabetic Human iPSC Potentiate Efficient Revascularization of Ischemic Retina
#> 389                                                                                                     In vivo hyperglycemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress
#> 390                                                                                                                                                                    Skeletal muscle regeneration is compromised in advanced diabetic peripheral neuropathy
#> 391                                                                                                                                                                               Adipocyte serine uptake curbs ROS generation and visceral adiposity [Human]
#> 392                                                                                                                                                                                                  Knockdown PTPRN expression inhibits U87 cell line growth
#> 393                                                                                                                                              Neutrophil extracellular trap induced dendritic cell activation leads to Th1 polarization in type 1 diabetes
#> 394                                                                                                                                               Chromatin state of MCF-7 breast cancer cells treated with proteasome inhibitor MG132 [histone_mod_chip_seq]
#> 395                                                                                                                               DNA methylation profiles in Taiwanese patients of Type-2 Diabetes (T2D) associated to Nephropathy (DN) and Retinopathy (DR)
#> 396                                                                                                                                                                                                                                       Fat_challenge_tests
#> 397                                                                                                                                                                         Profiling of RNAs from human islet-derived exosomes in a model of type 1 diabetes
#> 398                                                                                     Loss of ER and nuclear envelope-associated neutral sphingomyelinase SMPD4 causes a severe neurodevelopmental disorder with microcephaly and congenital arthrogryposis
#> 399                                                                                                                                                                                          bulk RNA-seq of human nucleusus pulposus from scoliosis patients
#> 400                                                                                                                                                                                  Identified  differentially expressed lncRNAs in Type 1 Diabetes Patients
#> 401                                                                                                                                                        bulk RNA-seq of human nucleusus pulposus cell differentiations from embryonic stem cells and iPSCs
#> 402                                                                                                  Transient PAX8 Expression in Islets During Pregnancy Correlates With β-Cell Survival, Revealing a Novel Candidate Gene in Gestational Diabetes Mellitus.
#> 403                                                                                                                                                                CD31 positive-extracellular vesicles from patients with type 2 diabetes: a miRNA signature
#> 404                                                                                                                   Transcriptome analysis-identified long noncoding RNA CRNDE in maintaining endothelial cell proliferation, migration, and tube formation
#> 405                                                                                                                                                                       A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism.
#> 406                                                                         A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism: Liver RNA profiles of lean non-diabetic, obese non-diabetic as well as obese diabetic humans.
#> 407                                                                                                          Comparison of Kidney Transcriptomic Profiles of Early and Advanced Diabetic Nephropathy Reveals Potential New Mechanisms for Disease Progression
#> 408                                                                                                                                                                          Expression data for patients with myocardial infarction (MI) vs healthy patients
#> 409                                                                                     Transcriptome analysis between primary and iPS-derived monocytes and macrophages and comparison of iPS-derived macrophages between CCR5 patients and healthy controls
#> 410                                                                                                                                              Transcriptome signatures reveal candidate key genes in the whole blood of patients with lumbar disc prolapse
#> 411                                                                                                                                        Inhibition of PARP 1 Protects Against Hyperglycemic-induced Neointimal Hyperplasia by Upregulating TFPI-2 Activity
#> 412                                                                                                                                            Urinary sediment transcriptomic and longitudinal data to investigate renal function decline in type 1 diabetes
#> 413                                                                                                                    Identification of microRNA-dependent gene regulatory networks driving human pancreatic endocrine cell differentiation [Islet ATAC-Seq]
#> 414                                                                                                                     Identification of microRNA-dependent gene regulatory networks driving human pancreatic endocrine cell differentiation [Islet RNA-Seq]
#> 415                                                                                                                                                      miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
#> 416                                                                                                                                                      miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
#> 417                                                                                           Combined use of astragalus polysaccharide and berberine attenuates insulin resistance in IR-HepG2 cells via regulation of the gluconeogenesis signaling pathway
#> 418                                                                                                                       Identification of microRNA-dependent gene regulatory networks driving human pancreatic endocrine cell differentiation [RNA-Seq III]
#> 419                                                                                                                                                      miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
#> 420                                                                                                                          Identification of microRNA-dependent gene regulatory networks driving human pancreatic endocrine cell differentiation [ATAC-seq]
#> 421                                                                                                                        Identification of microRNA-dependent gene regulatory networks driving human pancreatic endocrine cell differentiation [H1 RNA-seq]
#> 422                                                                                                                     Identification of microRNA-dependent gene regulatory networks driving human pancreatic endocrine cell differentiation [small RNA-seq]
#> 423                                                                                                                                                                                                                     6mer seed toxicity in viral microRNAs
#> 424                                                                                                                                                                Transcriptome profiling of subcutaneous and visceral adipose tissue from obese individuals
#> 425                                                                                                                                                   Single Cell RNASeq profiling of stromal vascular fraction from Subcutaneous and visceral adipose tissue
#> 426                                                                                 Multi-Parameter Analysis of Biobanked Human Bone Marrow Stromal Cells Shows Little Influence for Donor Age and Mild Comorbidities on Phenotypic and Functional Properties
#> 427                                                                                                                                                     Signaling protein antibody microarray analyses for islets of control and IFT88 knockout mice [SET100]
#> 428                                                                                                                                                               Phospho-antibody microarray analyses for islets of control and IFT88 knockout mice [PEX100]
#> 429                                                                                                                                                                                      Human Islet Response to Selected Type 1 Diabetes Associated Bacteria
#> 430                                                                                                                                                                            Edematous Severe Acute Malnutrition is Characterized by Hypomethylation of DNA
#> 431                                                                                                                                                      Cellular recruitment by podocyte-derived pro-migratory factors in assembly of the human renal filter
#> 432                                                                                                                                                                   Circular RNA expression profiling in diabetic foot ulcers and human normal acute wounds
#> 433                                                                                                                                                       A global transcriptome analysis of human epidermal keratinocytes upon knockdown of hsa_circ_0084443
#> 434                                                                                                                                                                                         Large-scale gene expression profiling  of hepatocellular adenomas
#> 435                                                                                                                                                                Placental Accreta Spectrum: Upregulated Cytotrophoblast DOCK4 Contributes to Over Invasion
#> 436                                                    Genome-wide analysis of hepatic gene expression in patients with non-alcoholic steatohepatitis (NASH) before and after 1 year supplementation with n-3 polyunsaturated fatty acids (PUFA) from fishoil
#> 437                                                                                                                                                                           Effect of high glucose on transcriptomic expression of cholangiocarcinoma cells
#> 438                                                                                                                                                Comparative Analysis of the Transcriptome of Latent Autoimmune Diabetes (LADA) Patients from Eastern China
#> 439                                                                                                                        The impact of pro-inflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes
#> 440                                                                                                                The impact of pro-inflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabtes [UMI-4C]
#> 441                                                                                                      The impact of pro-inflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabtes [H3K27ac ChIP-seq]
#> 442                                                                                                              The impact of pro-inflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabtes [ATAC-seq]
#> 443                                                        Differential messenger RNA expression in Granulosa Cells from polycystic ovary syndrome with Normoandrogen and Hyperandrogen: Identification of gene sets through bioinformatic Filtering analysis
#> 444                                                                                                                                           Proteomics in gastroparesis: Unique and overlapping protein signatures in diabetic and idiopathic gastroparesis
#> 445                                                                                                                                                                Metformin-induced alterations in peripheral blood cell trancriptome of healthy individuals
#> 446                                                                                                                                                                              The Single Cell Transcriptomic Landscape of Early Human Diabetic Nephropathy
#> 447                                                                                                                                   Systematic assessment of blood-borne microRNAs highlights molecular profiles of endurance sport and carbohydrate uptake
#> 448                                                                                                                                                  Single-cell sequencing reveals the relationship between phenotypes and genotypes of Klinefelter syndrome
#> 449                                                                                                                                                                                     Hyperglycemia promotes an aggressive phenotype in breast cancer cells
#> 450                                                                                                                                               Environmental Factors Influence the Epigenetic Signature of Newborns from Mothers with Gestational Diabetes
#> 451                                                                                                                                                  miRNA-27b-3p and miRNA-1228-3p correlate with the progression of Kidney Fibrosis in Diabetic Nephropathy
#> 452                                                                                                                                                                                                                           SC-beta Cell in vivo Maturation
#> 453                                                                                                                                                                                                                            RNA sequencing human monocytes
#> 454                                                                                                                                                  N6-methyladenosine (m6A) profiling of EndoC-bH1 cell line and RNA seq of Mettl14 knockout mice beta cell
#> 455                                                                                                                                                                    Phospho-antibody microarray analyses for islets of control and  Mettl14 knock-out mice
#> 456                                                                                                                                                                                             N6-methyladenosine (m6A) profiling of type II diabetes islets
#> 457                                                                                                                                                      Hyperglycemia acts in synergy with hypoxia to maintain the pro-inflammatory phenotype of macrophages
#> 458                                                                                                      Transcriptome as marker for nutrition-related health: added value of time course analyses during challenge tests before and after energy restriction
#> 459                                                                                                                   A transcriptomic analysis of primary mature adipocytes from lean, obese, and type 2 diabetic subjects: role of the extracellular matrix
#> 460                                                                                                                                                 Point mutations in the PDX1 transactivation domain impair human β-cell development and function (RNA-Seq)
#> 461                                                                                                                                                Point mutations in the PDX1 transactivation domain impair human β-cell development and function (ChIP-Seq)
#> 462                                                                                                                                         Point mutations in the PDX1 transactivation domain impair human β-cell development and function (mRNA microarray)
#> 463                                                                                                                                 Metformin alters human host responses to Mycobacterium tuberculosis in-vitro and in healthy human subjects [PBMC RNA-Seq]
#> 464                                                                                                                        Metformin alters human host responses to Mycobacterium tuberculosis in-vitro and in healthy human subjects [Ex vivo Blood RNA-Seq]
#> 465                                                                                                                                                                      scRNA-seq analysis of the dual expressors, B cells and T cells of a diabetes patient
#> 466                                                                                                                                           A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys
#> 467                                                                                   Phenotypic cooperation of a KCNQ2 exon 7 partial duplication and compound copy number variations in genes associated to a severe epileptic and neurodevelopmental delay
#> 468                                                                                                                                                                                                            Liver transcriptome of statin-treated patients
#> 469                                                                                                                                                                                 Charting in vitro beta cell differentiation by single cell RNA sequencing
#> 470                                                                                                                                                              Identification of metabolically distinct adipocyte progenitor cells in human adipose tissues
#> 471                                                                                                                                                           Association of cord blood methylation with neonatal leptin: an epigenome wide association study
#> 472                                                                                                                                                                                                                                  MAIT cell RNA sequencing
#> 473                                                                                                                                                                                                         Host response to IAV infections in human patients
#> 474                                                                                                                                                                                RNA sequence data in whole cell extracts of differentiated human podocytes
#> 475                                                                                                                       HNF1A deficiency impairs β-cell fate, granule maturation and function (scRNA-seq of 309 hESC-derived cells: Differentiation day 25)
#> 476                                                                                                                                                 Acute Effects of Single Doses of Bonito Fish Peptides and Vitamin D on Whole Blood Gene Expression Levels
#> 477                                                                                                                                                                Quantitative variation in m.3243A>G mutation produce discrete changes in energy metabolism
#> 478                                                                                                                                                                                                                       ATAC-seq on human pancreatic islets
#> 479                                                                                                                                       Culture of mature adipocytes under a permeable membrane and comparative analysis with different cell culture models
#> 480                                                                                                                                                           Plasma circulating extracellular RNAs in left ventricular remodeling post-myocardial infarction
#> 481                                                                                                                                                                          Novel risk variants affecting enhancers of TH1 and TREG cells in type 1 diabetes
#> 482                                                                                                                                                                Novel risk variants affecting enhancers of TH1 and TREG cells in type 1 diabetes [RNA-seq]
#> 483                                                                                                                                                               Novel risk variants affecting enhancers of TH1 and TREG cells in type 1 diabetes [ChIP-seq]
#> 484                                                                                                                           A co-expression analysis of the placental transcriptome in association with maternal pre-pregnancy BMI and newborn birth weight
#> 485                                                                                                                                                                                     HNF1A deficiency impairs β-cell fate, granule maturation and function
#> 486                                                                                                                                                     Epigenetic modulation of β-cells by interferon-α via PNPT11-miR-26a-TET2 triggers autoimmune diabetes
#> 487                                                                                                                                           Epigenetic modulation of β-cells by interferon-α via PNPT11-miR-26a-TET2 triggers autoimmune diabetes [RNA-seq]
#> 488                                                                                                                                 Epigenetic modulation of β-cells by interferon-α via PNPT11-miR-26a-TET2 triggers autoimmune diabetes [methylation array]
#> 489                                                                                                                                                                                 Serological autoantibody profiling of type 1 diabetes  by protein arrays.
#> 490                                                                                                                                                                                                                         ChIA-PET from MSiPS (ENCSR778FXH)
#> 491                                                                                                                                                                                                                    ChIA-PET from fibroblast (ENCSR732QOH)
#> 492                                                                                                                                                                                                                         ChIA-PET from MSLCL (ENCSR452NHL)
#> 493                                                                                                                                                       Cell type-specific immune phenotypes predict loss of insulin secretion in new-onset type 1 diabetes
#> 494                                                                                                                                                                      B lymphocyte alterations accompany abatacept resistance in new-onset type 1 diabetes
#> 495                                                                                                                                                                            Transcriptomic Profiling of Trophoblast Fusion Using BeWo and JEG-3 Cell Lines
#> 496                                                                                                              Integrated analysis of genetic variants regulating retinal transcriptome (GREx) identifies genes underlying age-related macular degeneration
#> 497                                                                                                                                                                                       Preeclamptic placentae release factors that damage neurons in vitro
#> 498                                                                                                                                          Short-term low calorie diet remodels skeletal muscle lipid profile and metabolic gene expression in obese adults
#> 499                                                                                                                                                                        Metformin reverses gene expression signautres in hyperglycaemics endothelial cells
#> 500                                                                                                    DNA Hypermethylation at Loci Associated with Diabetes, Obesity and Cardiac Abnormalities in CD3+ Lymphocytes of Intrauterine Growth Restricted Newbors
#> 501                                                                                                                                                    The diurnal rhythm of adipose tissue gene expression is reduced in obese patients with type 2 diabetes
#> 502                                                                                                                                                           Transcriptomics analysis of Colon tumor xenograft model in streptozotocin-induced diabetic mice
#> 503                                                                                                                      Transcriptomics analysis of paired tumor and normal mucosa samples in a cohort of patients with colon cancer, with and without T2DM.
#> 504                                                                                                                                           Patient adipose stem cell-derived adipocytes reveal genetic variation that predicts anti-diabetic drug response
#> 505                                                                                                                                  Circulating Exosomal miR-20b-5p is Elevated in Type 2 Diabetes and Could Impair Insulin Action in Human Skeletal Muscle.
#> 506                                                                                                                                            EndoC-βH1 multiomic profiling defines gene regulatory programs intrinsic to human β cell identity and function
#> 507                                                                                                                                                  Genome-Wide Analyses Identify Filamin-A (FLNA) as a Novel Downstream Target for Insulin and IGF1 Action.
#> 508                                                                                                               miRNA seq of feto-placental arterial endothelial cells (pfEC) after normal pregnancy vs pregnancy complicated by gestational diabetes (GDM)
#> 509                                                                                                                                           Identification of molecular signatures of cystic fibrosis disease status using plasma-based functional genomics
#> 510                                                   High-resolution map of copy number variations in motor cortex of Control and Sporadic Amyotrphic Lateral Sclerosis patients by using a customized exon-centric comparative genomic hybridization array.
#> 511                  Genome–wide gene expression profile of adipocytes and infiltration macrophages obtained from abdominal (visceral and subcutaneous) and peripheral (thigh) adipose depots from Normal Glucose Tolerant and Type 2 Diabetics Asian Indians
#> 512                                                                                                                                                                          Affymetrix microarray analysis of the effects of isonicotinamide on HEK293 cells
#> 513                                                                                                                                                                             Affymetrix microarray analysis of the effects of nicotinamide on HEK293 cells
#> 514                                                                                                                                Primate fetal hepatic response to maternal obesity: epigenetic signaling pathways and lipid accumulation [gene expression]
#> 515                                                                                                                                                                                                         ENPP6 as a neural regulator of visceral adiposity
#> 516                                                                                                                                                                      Single cell transcriptome profiling of mouse and hESC-derived pancreatic progenitors
#> 517                                                                                                                                                                           Diabetes Remission Using Glucose-Responsive Insulin-Producing Human alpha-Cells
#> 518                                                                                                                                                                                                      Expression analysis of λH1-hESC derived β-like cells
#> 519                                                                                                                                                                               Diabetes Remission Using Glucose-Responsive Insulin-Producing Human α-Cells
#> 520                                                                                                                                             Therapeutic potential of targeting miR-141 in intervertebral disc degeneration: first steps toward the clinic
#> 521                                                                                                                      Elevated T cell levels in peripheral blood predict poor clinical response following rituximab treatment in new-onset type 1 diabetes
#> 522                                                                                                                             Effects of Cadmium Exposure on DNA Methylation at Imprinting Control Regions and Genome-Wide in Mothers and Newborn Children.
#> 523                                                                                                        Single-cell RNA sequencing enables transcriptomic analysis of iPSC-derived beta-cells in a model of neonatal diabetes caused by insulin mutations.
#> 524                                                                                                                                         Integrative molecular and clinical analysis of intrahepatic cholangiocarcinoma reveals two prognostic subclassees
#> 525                                                                                                                                                Abnormal neutrophil signature in the blood and pancreas of pre-symptomatic and symptomatic type 1 diabetes
#> 526                                                                                                                                           Pan-senescence transcriptome analysis identified RRAD as a marker and negative regulator of cellular senescence
#> 527                                                                                                                                                                             Profiling of vascular organoid endothelial cells and pericytes from iPS cells
#> 528                                                                                                   Stable oxidative cytosine modifications accumulate in cardiac mesenchymal cells from Type2 diabetes patients: rescue by alpha-ketoglutarate and TET-TDG
#> 529                                                     Stable oxidative cytosine modifications accumulate in cardiac mesenchymal cells from Type2 diabetes patients: rescue by alpha-ketoglutarate and TET-TDG functional reactivation [human cells RNA-seq]
#> 530                                                                                                                                 Diabetes Mellitus Drives Extracellular Vesicle Secretion and Promotes Increased Internalization by Circulating Leukocytes
#> 531                                                                                                         Specific targeting of the common gamma chain blocks cooperative reprogramming of human tissue-resident cytotoxic T lymphocytes by IL-15 and IL-21
#> 532                                                                                                                                                Human Pancreatic Islets Expressing HNF1A Variant Have Defective β cell Transcriptional Regulatory Networks
#> 533                                                                                                                                           High-throughput single cell transcriptome analysis and CRISPR screen identify key β cell-specific disease genes
#> 534                                                                                                                                                                NTPDase3 antibody targets adult human pancreatic β-cells for in vitro and in vivo analysis
#> 535                                                                                                                                                                     Identification of early biological changes in palmitate-treated isolated human islets
#> 536                                                                                                                                                           Gene array of laser capture microdissectioned human diabetic vs non-diabetic plaque macrophages
#> 537                                                                                                                               Circadian misalignment induces fatty acid metabolism gene profiles and induces insulin resistance in human skeletal muscle.
#> 538                                                                                                                                                          JCAD/KIAA1462, a coronary artery disease-associated gene product, regulates endothelial function
#> 539                                                                              Conventional and neo-antigenic peptides naturally processed and presented by beta cells are targeted by circulating naïve CD8+ T cells in type 1 diabetic and healthy donors
#> 540                                                                                     Human Feto-placental Arterial and Venous Endothelial Cells are Differentially Programmed by Gestational Diabetes Mellitus Resulting in Cell-specific Barrier Function
#> 541                                                                             Human Feto-placental Arterial and Venous Endothelial Cells are Differentially Programmed by Gestational Diabetes Mellitus Resulting in Cell-specific Barrier Function Changes
#> 542                                                                                                                                                                                        Endothelial cells derived from iPSC in response to diabetic medium
#> 543                                                                                                                                                                                                   Exon Level Expression Profiling of Diabetic Nephropathy
#> 544                                                                                                                               Functional Genomics Analysis of Islets from Recent and Longstanding T1D Reveals the Need for Distinct Approaches to Therapy
#> 545                                                              Innate immune activity differentiate subtypes in new onset Type 1 diabetes that predict duration of the post-onset partial remission and correlate with responsiveness to CTLA4-Ig treatment
#> 546                                                                                                                                                      A new axis linking diabetes to cancer: Glucose regulates tumor suppressor TET2 and 5hmC through AMPK
#> 547                                                                                                                                                            Expression data of A2058-TET2WT, A2058-TET2M, and Mock cells treated under high-g and normal-g
#> 548                                                                                                                                                                                         Dysregulated circRNAs in plasma from active tuberculosis patients
#> 549                                                                                                                                      Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes
#> 550                                                                                                                                                                                                  RNA Expression data for early diabetic nephropathy (EDN)
#> 551                                                                                                                                                                      Discovering human diabetes-risk gene function with genetics and physiological assays
#> 552                                                                                                                              Propargite, an environmental chemical, interacts with GWAS identified diabetes genes to impact human pancreatic β-cell death
#> 553                                                                                                             Propargite, an environmental chemical, interacts with GWAS identified diabetes genes to impact human pancreatic β-cell death [PTPN2 knockout]
#> 554                                                                                                       Propargite, an environmental chemical, interacts with GWAS identified diabetes genes to impact human pancreatic β-cell death [propargite treatment]
#> 555                                                                                                                                                                    CRISPR/Cas9-targeted removal of unwanted sequences from small-RNA sequencing libraries
#> 556                                                                                                                                                                 Association of Elevated Urinary miR-126, miR-155 and miR-29b with Diabetic Kidney Disease
#> 557                                                                                                                                                                                                                    Expression data from childhood obesity
#> 558                                                                                                                                              Integrated transcriptomics network analysis of miRNA and mRNA in human myometrium in term and preterm labor.
#> 559                                                                                                                                                                                      Effect of TDNC1 ectopic expression on global gene expression pattern
#> 560                                                                                                                                                        A global transcriptome analysis of human epidermal keratinocytes upon inhibition of lncRNA WAKMAR1
#> 561                                                                                                                                                                                               Discovery of a Drug Candidate for GLIS3-Associated Diabetes
#> 562                                                                                                                                                                                                                        The role of CFTR in islet function
#> 563                                                                       Pure epicatechin and inflammatory gene expression profiles in circulating immune cells in (pre) hypertensive adults; a randomized double-blind, placebo-controlled, crossover trial
#> 564                                                                                                                                                             Differential metabolic effects of insulin detemir versus NPH in patients with type 2 diabetes
#> 565                                                                                                                                                      Effect of rosiglitazone treatment on insulin sensitivity in type 2 diabetic patients skeletal muscle
#> 566                                                                                                                                                     De novo reconstruction of human adipose reveals conserved lncRNAs as regulators of brown adipogenesis
#> 567                                                                                                                                                         Altered adipose lipid mobilization predicts long-term weight gain and impaired glucose metabolism
#> 568                                                                                                                                                       Bioinformatics analysis of microRNAs related to blood stasis syndrome in diabetes mellitus patients
#> 569                                                                                                                                                   Bioinformatics analysis of transcriptome related to blood stasis syndrome in diabetes mellitus patients
#> 570                                                                                                     GABA regulates release of inflammatory cytokines from peripheral blood mononuclear cells and CD4+ T cells and is immunosuppressive in type 1 diabetes
#> 571                                                                                                                                Placental methylation arrays for the assessment of epigenetic regulation in transcriptional subtypes of human preeclampsia
#> 572                                                                                                                                                          Genome-wide analysis of PDX1 target genes in human pancreatic progenitors [expression profiling]
#> 573                                                                                                                                                         Transcriptomes of iPSC-derived and post-mortum Hypothalamus Neurons from obese and control donors
#> 574                                                                                                       The lipodystrophic hotspot lamin A p.R482W mutation deregulates the mesodermal inducer T/Brachyury and early vascular differentiation gene networks
#> 575                                                                                                                                                                                                     Unique Circulating MicroRNA profiles in HIV Infection
#> 576                                                                                                                                  Heart failure patients' peripheral blood mononuclear cell gene expression profiles before mechanical circulatory support
#> 577                                                                                                                                                        A SRp55-regulated alternative splicing network controls pancreatic beta cell survival and function
#> 578                                                                                                                                                                                                  Expression data from SOX9 overexpressing EndoC-ßH1 cells
#> 579                                                                                                                                                                                                       Expression data from PolyIC treated EndoC-ßH1 cells
#> 580                                                                                                                                                                                              Expression profiling of circular RNAs in human islet samples
#> 581                                                                                                                           FABP4 overexpressed in intratumoral hepatic stellate cells within hepatocellular carcinoma with metabolic risk factors (part 2)
#> 582                                                                                                                           FABP4 overexpressed in intratumoral hepatic stellate cells within hepatocellular carcinoma with metabolic risk factors (part 1)
#> 583                                                                                                                                                Tubulointerstitial transcriptome from ERCB subjects with chronic kidney disease and living donor biopsies.
#> 584                                                                                                                                                                         Glomerular Transcriptome from European Renal cDNA Bank subjects and living donors
#> 585                                                                                                                                                                                  Transcription factors operate across disease loci: EBNA2 in autoimmunity
#> 586                                                                                                                                                                 Asynchronous remodeling is a driver of failed regeneration in Duchenne muscular dystrophy
#> 587                                                                                                                                                         Valproic acid attenuates hyperglycemia induced complement and coagulation cascade gene expression
#> 588                                                                                                                                                                                                      Dermal endothelial cells of type 2 diabetic patients
#> 589                                                                                                                                   RNA sequencing data of whole blood cells of normal glucose tolerant (NGT) and gestational diabetes (GDM) pregnant women
#> 590                                                                                  Genomic Profiling of Diabetic Foot Ulcers Identifies miR-15b-5p as a Major Regulator that Leads to Suboptimal Inflammatory Response and Diminished DNA Repair Mechanisms
#> 591                                                                                                                                                                                    α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes
#> 592                                                                                                                                                 Affymetrix profiling of IMIDIA biobank samples from organ donors and partially pancreatectomized patients
#> 593                                                                                                    Affymetrix profiling of IMIDIA biobank samples from organ donors and partially pancreatectomized patients [partially pancreatectomized patient cohort]
#> 594                                                                                                                            Affymetrix profiling of IMIDIA biobank samples from organ donors and partially pancreatectomized patients [organ donor cohort]
#> 595                                                                                                                                                                   HDAC inhibitor SAHA reverses inflammatory gene expression in diabetic endothelial cells
#> 596                                                                                                                                                                                          RNA-seq in neutrophils from patients with intracranial aneurysms
#> 597                                                                                                                                                                                       Glucose inhibits cardiac maturation through nucleotide biosynthesis
#> 598                                                                                                                    Altered intestinal functions and increased local inflammation in insulin-resistant obese subjects: a gene-expression profile analysis.
#> 599                                                                                                                                              Clinical Evidence Supports a Protective Role for CXCL5 in Coronary Artery Disease Progression in the Elderly
#> 600                                                                                                                           Gene expression data from Phase 2 of the SAMARA study (Supporting a Multi-disciplinary Approach to Researching Atherosclerosis)
#> 601                                                                                                                                Genotyping data from Phase 2 of the SAMARA study (Supporting a Multi-disciplinary Approach to Researching Atherosclerosis)
#> 602                                                                                                                                           Small RNA-seq analysis of circulating miRNAs to identify phenotypic variability in Friedreich's ataxia patients
#> 603                                                                                                                           Single cell transcriptome analysis of human pancreas reveals transcriptional signatures of aging and somatic mutation patterns.
#> 604                                                                                                                                                                                Real-time quantitative PCR analysis of 232 microRNAs in human oral tissues
#> 605                                                                                                                                      Small RNA-seq during acute maximal exercise reveal RNAs involved in vascular inflammation and cardiometabolic health
#> 606                                                                                                                                              Discovery and validation of a gene expression profile for human islet integrity and transplant functionality
#> 607                                                                                                                            DNA methylation in blood from neonatal screening cards and the association with BMI and insulin sensitivity in early childhood
#> 608                                                                                                                                            Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes
#> 609                                                                                                                                                         Preclinical evaluation of the BET bromodomain inhibitor BAY 1238097 for the treatment of lymphoma
#> 610                                                                                                                                            lncRNA Expression Signatures in Response to Jiangtang Tiaozhi Formular in T2DM with Obesity and Hyperlipidemia
#> 611                                                                                                                         Global gene expression profiling and senescence biomarker analysis of hESC exposed to H2O2 induced non-cytotoxic oxidative stress
#> 612                                                                                                                                                                                             Effects of isoxazole (ISX) on long-term cultured human islets
#> 613                                                                                                                    Transcriptomic profile in lymphomonocytes of healthy subjects identifies an early signature of insulin resistance and related diseases
#> 614                                                                                                                                     Transcriptome-based network analysis reveals renal cell type-specific dysregulation of hypoxia-associated transcripts
#> 615                                                                                                                         Transcriptome-based network analysis reveals renal cell type-specific dysregulation of hypoxia-associated transcripts [glomeruli]
#> 616                                                                                                                            Transcriptome-based network analysis reveals renal cell type-specific dysregulation of hypoxia-associated transcripts [Tub-FE]
#> 617                                                                                                                                                     Dysregulation of a miR-23b/27b-p53 axis impairs muscle differentiation in humans with type 2 diabetes
#> 618                                                                                                                                                                                         Single-cell transcriptomics of East-Asian pancreatic islets cells
#> 619                                                                                                                                           DNA methylation profiles in sibling pairs discordant for intrauterine exposure to maternal gestational diabetes
#> 620                                                                                                                                                                    Proteomic Comparison of Acute Myocardial Infarction and Stress Cardiomyopathy in Women
#> 621                                                                                                                                                                   Acute Exercise Bout Effects on GH and IGF1 in Prediabetic and Healthy African Americans
#> 622                                                                                                              Human monocyte subsets are transcriptionally and functionally altered in aging in response to pattern recognition receptor agonists [ExVivo]
#> 623                                                                                                             Human monocyte subsets are transcriptionally and functionally altered in aging in response to pattern recognition receptor agonists [InVitro]
#> 624                                                                                                                                                                            Entrainment of Breast Cell Lines Results in Rhythmic Fluctuations of MicroRNAs
#> 625                                                                                                                                                                       Effect of hyperglycemia on the transcriptional profile of primary human macrophages
#> 626                                                                                                                                                                                                              Expression data from liver of obese patients
#> 627                                                                                                                           IL-6/Stat3-Dependent Induction of Distinct, Obesity-Associated Natural Killer Cells Deteriorates Energy and Glucose Homeostasis
#> 628                                                                                                                                                                              Glucose impairs tamoxifen sensitivity modulating CTGF in breast cancer cells
#> 629                                                                                                                                                    Using hESCs to Probe the Interaction of CDKAL1 and MT1E, Two GWAS identified Diabetes Associated Genes
#> 630                                                                                                                                                                                                                         Rader HHDL and BioBank genotyping
#> 631                                                                                                                                                            Sirt6 Deficiency Exacerbates Podocyte Injury and Proteinuria through Targeting Notch Signaling
#> 632                                                                                                                                                    Serum miRNAs from Drug-induced liver injury, Hepatitis B, Liver cirrhosis and Type 2 Diabetes patients
#> 633                                                                                                                                                       Single cell RNA-seq reveals expansion of IGRP-reactive CD4+ T cells in recent onset type I diabetes
#> 634                                                                                   Single cell RNA-seq reveals expansion of IGRP-reactive CD4+ T cells in recent onset type I diabetes (single-cell RNA-seq of CD4+ pooled islet antigen-reactive T cells)
#> 635                                                                                              Single cell RNA-seq reveals expansion of IGRP-reactive CD4+ T cells in recent onset type I diabetes (single-cell RNA-seq of CD8+ influenza-reactive T cells)
#> 636                                                                                                                        Single cell RNA-seq reveals expansion of IGRP-reactive CD4+ T cells in recent onset type I diabetes (bulk RNA-seq of T-cell clone)
#> 637                                                                                                                 Single cell RNA-seq reveals expansion of IGRP-reactive CD4+ T cells in recent onset type I diabetes (single-cell RNA-seq of T-cell clone)
#> 638                                                                                                                                                                                        Glucose upregulates a limited number of genes in human beta cells.
#> 639                                                                                                                          Acute and chronic treatment of trametinib plus lapatinib in patient-derived xenografts (PDX) of pancreatic adenocarcinoma (PDAC)
#> 640                                                                                                                                                                                                 A DNA methylation atlas of the human eye and its diseases
#> 641                                                                                                                                                                 Aberrantly Expressed Long Non-coding RNAs In CD8+ T Cells Response to Active Tuberculosis
#> 642                                                                                                                                      Prenatal Pesticide Exposure Interacts with a Common Polymorphism in the PON1 Gene Leading to DNA Methylation Changes
#> 643                                                                                                                                     Characterizing the global changes in miRNA expression in human atrial appendages with persistent atrial fibrillation.
#> 644                                                                                                                                                                                                      Circulating miRNAs for gestational diabetes mellitus
#> 645                                                                                                                                                               RNA-sequencing of human skeletal myocytes from healthy, obese, and type 2 diabetic subjects
#> 646                                                                                                                                           Transcriptomic Analysis of Endothelial Cells from Fibrovascular Membranes in Proliferative Diabetic Retinopathy
#> 647                                                                                                                                         Epigenetic signatures of gestational diabetes mellitus on ATP5A1, PRKCH, SLC17A4 and HIF3A cord blood methylation
#> 648                                                                                                           Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans
#> 649                                                                                                                                                                        Microarray analysis of CD9high and CD9low progenitors isolated from adipose tissue
#> 650                                                                                                                                    Microarray analysis of CD9high and CD9low progenitors isolated from omental adipose tissue of morbid obese individuals
#> 651                                                                                                                                                                                                    Interaction between mitoNEET and NAF-1 in cancer cells
#> 652                                                                                                                                              Open chromatin profiling of human postmortem brain infers functional roles for non-coding schizophrenia loci
#> 653                                                                                                                                                               Differential expression analysis between Microadenoma and Macroadenoma in Cushing's Disease
#> 654                                                                                                                                         Transcriptional profiling of diabetic peripheral neuropathy patients, diabetic patients, and healthy participants
#> 655                                                                                                                               Tissue-Specific and Genetic Regulation of Insulin Sensitivity-Associated Transcripts in African Americans [skeletal muscle]
#> 656                                                                                                                          Tissue-Specific and Genetic Regulation of Insulin Sensitivity-Associated Transcripts in African Americans [subcutaneous adipose]
#> 657                                                                                         Characterization of molecular functions, pathways and protein classes affected by aging-related changes of miRNA expression in peripheral blood mononuclear cells
#> 658                                                                                                                                        Pathogenic Implications for Autoimmune Mechanisms Derived by Comparative eQTL Analysis of CD4+ Versus CD8+ T cells
#> 659                                                                                                                                                                                                  Serum microRNA profile of human type 1 diabetes mellitus
#> 660                                                                                                                                                                     Impact of Visceral Fat Adiposity on Gene Expression Profile in Peripheral Blood Cells
#> 661                                                                                                                             Adipose tissue gene expression is differentially regulated with different rates of weight loss in overweight and obese humans
#> 662                                                                                                                                                              Transcriptional Profiling of Dysregulated lncRNAs in B cells Response to Active Tuberculosis
#> 663                                                                                                                                                             Artemisinins target GABA receptor signaling to induce alpha to beta cell transdifferentiation
#> 664                                                                                                                                       Epigenome-wide association in the METSIM cohort identifies 22 novel loci for diabetes and metabolic syndrome traits
#> 665                                                              Serum microRNA signatures are indicative of skeletal fractures in post-menopausal women with and without type 2 diabetes and influence osteo-genic differentiation of mesenchymal stem cells
#> 666                                                                                                                                                                             Sequential global gene expression analysis of glucose stimulated human islets
#> 667                                                                                                                                                         Transcriptome profiles of differentiated hepatoma cells infected with oncogenic hepatitis C virus
#> 668                                                                                                                                                                                 Healthy glucocorticoid receptor N363S SNP carriers and metabolic syndrome
#> 669                                                                               Partially exhausted CD8+ T cells are associated with clinically beneficial response to Teplizumab in new onset type I diabetes (single-cell RNA-seq of sorted CD8+ T-cells)
#> 670                                                                                                               Partially exhausted CD8+ T cells are associated with clinically beneficial response to Teplizumab in new onset type I diabetes (microarray)
#> 671                                                                                                                      Conserved recurrent gene mutations correlate with pathway deregulation and clinical outcomes of lung adenocarcinoma in never-smokers
#> 672                                                                                                                            Partially exhausted CD8+ T cells are associated with clinically beneficial response to Teplizumab in new onset type I diabetes
#> 673                                                                                                      Partially exhausted CD8+ T cells are associated with clinically beneficial response to Teplizumab in new onset type I diabetes (whole blood RNA-seq)
#> 674                                                                                      Partially exhausted CD8+ T cells are associated with clinically beneficial response to Teplizumab in new onset type I diabetes (bulk RNA-seq of sorted CD8+ T-cells)
#> 675                                                                                                                                                                     Gene expression in the peripheral whole blood of established Type 1 diabetes patients
#> 676                                                                                                                      Single cell transcriptomics defines human islet cell signatures and reveals cell-type-specific expression changes in type 2 diabetes
#> 677                                                                                                        Single cell transcriptomics defines human islet cell signatures and reveals cell-type-specific expression changes in type 2 diabetes [single cell]
#> 678                                                                                                               Single cell transcriptomics defines human islet cell signatures and reveals cell-type-specific expression changes in type 2 diabetes [bulk]
#> 679                                                     Genome-wide analysis of hepatic gene expression in patients with non-alcoholic fatty liver disease  and in healthy donors in relation to hepatic fatty acid composition and other nutritional factors
#> 680                                                                                                                                                                                               Pleiotropic Analysis of Lung Cancer and Blood Triglycerides
#> 681  Transcriptome comparison of PAX6 ablated mouse beta cells to WT beta cells, ChIP-seq analysis of PAX6 bound sites both in mouse and human beta cell lines (Min6 and EndoC), and ChIP-seq analysis fo histone mark H3K9ac on mouse pancreatic beta cells.
#> 682                                                                                                                                           Differences in genome-wide gene expression response in PBMCs between young and old men upon caloric restriction
#> 683                                                                                                                                                                 Hepatocyte Nuclear Factor 1 coordinates multiple functions of intestinal epithelial cells
#> 684                                                                                                                                                                                 Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan
#> 685                                                                                                                                                                                        A single-cell transcriptome atlas of the human pancreas [CEL-seq2]
#> 686                                                                                                                                                                Potential Epigenetic Biomarkers of Obesity Related Insulin Resistance in Human Whole Blood
#> 687                                                                                   Integrative Analysis of miRNA and mRNA Paired Expression Profiling of Primary Fibroblast Derived from Diabetic Foot Ulcers Reveals Multiple Impaired Cellular Functions
#> 688                                                                                                                                       A single-cell transcriptomic map of the human and mouse pancreas reveals inter- and intra-cell population structure
#> 689                                                                                                                                            Comparative study of the transcriptome of HUVECs from infants born to mothers diagnosed with GDM and controls.
#> 690                                                                                                                    Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression
#> 691                                                                                                                             Differentially Expressed Gene Transcripts Using RNA Sequencing from the Blood of Immunosuppressed Kidney Allograft Recipients
#> 692                                                                                                      Genome-wide RNA-sequencing of human islets 48 hour after transduction with adenoviruses expressing either GFP (control), or histone chaperone ASF1B.
#> 693                                                                                                                              Expression profiling of cutaneous squamous cell carcinoma with perineural invasion implicates the p53 pathway in the process
#> 694                                                                                                                                                                                  RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes
#> 695                                                                        Response of peripheral blood mononuclear cells from  20 healthy donor and 15 patients with type 1 diabetes to type 1 diabetogenic protein (IGRP, PPI) derived peptide stimulation.
#> 696                                     Response of peripheral blood mononuclear cells from  15 healthy donor and 15 patients with type 1 diabetes to type 1 diabetogenic protein (GAD65, IGRP, PPI, ZnT8) and influenza virus M derived peptide stimulation.
#> 697                                                                                                                                                       The expression profiling of circular RNAs (circRNA) in human intervertebral disc degeneration (IDD)
#> 698                                                                                                                                                                                                                        Tacrolimus in diabetic nephropathy
#> 699                                                                                                                                                                               The epigenetic signature of systemic insulin resistance in obese women [SC]
#> 700                                                                                                                                                                               The epigenetic signature of systemic insulin resistance in obese women [OM]
#> 701                                                                                                                                                                               The epigenetic signature of systemic insulin resistance in obese women [BL]
#> 702                                                                                                                                  Conversion of Human Gastric Epithelial Cells to Multipotent Endodermal Progenitors using Defined Small Molecules [array]
#> 703                                                                                                                        Conversion of Human Gastric Epithelial Cells to Multipotent Endodermal Progenitors using Defined Small Molecules [DNA methylation]
#> 704                                                                                                                        Conversion of Human Gastric Epithelial Cells to Multipotent Endodermal Progenitors using Defined Small Molecules [gene expression]
#> 705                                                                                High-throughput sequencing reveals key genes and immune homeostatic pathways activated in myeloid dendritic cells by Porphyromonas gingivalis 381 and its fimbrial mutants
#> 706                                                                                                                                                                                       Discovery of a Drug that Targets a Diabetes Gene identified by GWAS
#> 707                                                                                                                                          Single cell RNA-seq of human pancreatic endocrine cells from Juvenile, adult control and type 2 diabetic donors.
#> 708                                                                                                                                                       DNA methylation anaylsis of placenta samples exposed to variable levels of arsenic during pregnancy
#> 709                                                                                                                                                              Revisiting the microRNA expression profiling of human intervertebral disc degeneration (IDD)
#> 710                                                                                                                                          TGFβ contributes to impaired exercise response by suppression of mitochondrial key regulators in skeletal muscle
#> 711                                                                                                                                                                                                   A single-cell transcriptome atlas of the human pancreas
#> 712                                                                                                   RNA sequencing of pancreatic adenocarcinoma tumors yields novel expression patterns associated with long-term survival and reveals a role for *ANGPTL4*
#> 713                                                                                                                                                                                          RNA-sequencing of human pancreatic adenocarcinoma cancer tissues
#> 714                                                                                                                                                Novel Regions of Variable DNA Methylation in Human Placenta associated with Newborn Neurobehavioral Traits
#> 715                                                                                                                                                                                                Hyperglycemia induced microRNAs in endothelial dysfunction
#> 716                                                                                                                                                                                                             Comparsion of IGRP reactive CD8 T cell clones
#> 717                                                                                               DNA-methylation profiling of Whole blood genomic DNAs collected at EDIC baseline and monocytes at EDIC years 16/17 yrs from participants of DCCT/EDIC study
#> 718                                                    DNA-methylation profiling of monocyte genomic DNAs collected from participants of  Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study
#> 719                                                 DNA-methylation profiling of Whole blood genomic DNAs collected from participants of  Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study
#> 720                                                                                                                                                                         Nfib promotes Metastasis through a Widespread Increase in Chromatin Accessibility
#> 721                                                                                                                                                              Nfib promotes Metastasis through a Widespread Increase in Chromatin Accessibility [ATAC-seq]
#> 722                                                                                                                                                           5-hydroxymethylcytosine-mediated alteration of transposon activity associated with Preeclampsia
#> 723                                                                                                                                  Embryonic atrazine exposure alters zebrafish and human miRNAs associated with angiogenesis, cancer, and neurodevelopment
#> 724                                                                                                                                                                                              Epigenomic landscapes of human primary pancreatic cell types
#> 725                                                                                                                                                                                                                         Study of Topoisomerase I in human
#> 726                                                                                                                                                                             Methylome-wide analysis of chronic HIV infected patients and healthy controls
#> 727                                                                                                                                                                                     Generation of Stem Cell-Derived β Cells from Type 1 Diabetic Patients
#> 728                                                                                                                           Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients [methylome analysis]
#> 729                                                                                                                       Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients [transcriptome analysis]
#> 730                                                                                                                                                                                   fibroblasts and iPS cells from patients with insulin receptor mutations
#> 731                                                                                                                                                                           Omics profiling of 21 novel primary and metastatic colorectal cancer cell lines
#> 732                                                                                                                                SNP-array profiling of 21 novel primary and metastatic colorectal cancer cell lines [Illumina HumanExome-12 v1.2 BeadChip]
#> 733                                                                                                                                SNP-array profiling of 21 novel primary and metastatic colorectal cancer cell lines [Illumina HumanExome-12 v1.0 BeadChip]
#> 734                                                                                                                                                        Systematic Evaluation Of Genes And Genetic Variants Associated With Type 1 Diabetes Susceptibility
#> 735                                                                                                                                                                                                   Gene expression response to mitochondrial DNA depletion
#> 736                                                                                                                                Gene expression profiling in human precision-cut liver slices upon treatment with the FXR agonist obeticholic acid [human]
#> 737                                                      Perivascular Progenitor Cells Derived from Human Embryonic Stem Cells Exhibit Functional Characteristics of Pericytes, and Improve the Retinal Vasculature in a Rodent Model of Diabetic Retinopathy
#> 738                                                                                                                   Integrated Analysis of Dysregulated lncRNA and mRNA Expression profiles of myocardial sleevesof pulmonary veins in  atrial fibrillation
#> 739                                                                                                                                                                                   Maternal-diabetes induced gene expression changes in the umbilical cord
#> 740                                                                                                                                                                                     Palmitate-induced gene expression in human gingival fibroblasts (HGF)
#> 741                                                                                                                                              An integrative analysis of renal miRNA- and mRNA-expression signatures in progressive chronic kidney disease
#> 742                                                                                                                          An integrative analysis of renal miRNA- and mRNA-expression signatures in progressive chronic kidney disease [validation cohort]
#> 743                                                                                                                           An integrative analysis of renal miRNA- and mRNA-expression signatures in progressive chronic kidney disease [discovery cohort]
#> 744                                                                                                                                                                                Altered microRNA expression in individuals at high risk of type 1 diabetes
#> 745                                                                                                                                                             Integration of ATAC-seq and RNA-seq Identifies Human Alpha Cell and Beta Cell Signature Genes
#> 746                                                                                                                                     Tetraspanin-2 promotes glucotoxic apoptosis by regulating JNK/β-catenin signaling pathway in human pancreatic β-cells
#> 747                                                                                                                                                                                                                                     Rader HHDL genotyping
#> 748                                                                                                              Human skeletal muscle gene expression analysis on Lean, obese insulin sensitive, obese insulin resistant and obese Type II diabetic subjects
#> 749                                                                                                                                               Tissue Transcriptome Driven Identification of Epidermal Growth Factor as a Chronic Kidney Disease Biomarker
#> 750                                                                                                                                                                                                                       Mexican Patients with Breast Cancer
#> 751                                                                                                                                                                                                    Gene Expression of Mexican Patients with Breast Cancer
#> 752                                                                                                                                                                                                  miRNAs Expression of Mexican Patients with Breast Cancer
#> 753                                                                                                                                          Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci
#> 754                                                                                                                       Blood transcriptional biomarkers for active TB among US patients: A case-control study with systematic cross-classifier evaluation.
#> 755                                                                                                                                Peripheral blood transcriptome profiles from an RNA Pilot Study within the United States Health and Retirement Study (HRS)
#> 756                                                                                                         Near-whole-genome transcriptome analysis of gene expression in human skeletal muscle tissue at baseline in obese individuals with Type 2 Diabetes
#> 757                                                                                                                                                         Pancreatic Beta Cell Enhancers Regulate Rhythmic Transcription of Exocyst Triggering and Diabetes
#> 758                                                                                                                                          Genome-wide Circadian Control of Transcription at Active Enhancers Regulates Insulin Secretion and Diabetes Risk
#> 759                                                                                                                                                                                                                Expression data from MSC-treated monocytes
#> 760                                                                                                                                                                  Transcriptome profile of peripheral blood from pancreatic ductal adenocarcinoma patients
#> 761                                                                                                                                                                             miRNA profile in the vitreous of proliferative vitreoretinal disease patients
#> 762                                                                                                                                                  Gene expression in the pancreas of healthy control, auto-antibody positive, and type 1 diabetic subjects
#> 763                                                                                                                           Chlorella ingestion and suppression of resistin gene expression in borderline diabetics: a randomized, placebo-controlled study
#> 764                                                                                                                                                                       Genetic and epigenetic variation in the lineage specification of regulatory T cells
#> 765                                                                                                                Plasma induced signatures reveal an extracellular milieu possessing an immunoregulatory bias in treatment naïve inflammatory bowel disease
#> 766                                                                                                                                      Canakinumab treatment for recent-onset type 1 diabeties mellitus: a multicenter randomized, placebo-controlled trial
#> 767                                                                                                                          Interleukin-1 receptor antagonist for recent-onset type 1 diabeties mellitus: a multicenter randomized, placebo-controlled trial
#> 768                                                                                                                                                                                                          Influence of muscle activity on paralyzed muscle
#> 769                                                                                                                                                      Preserved DNA Damage Checkpoint Pathway Protects From Complications in Long-standing Type 1 Diabetes
#> 770                                                                                                          Epigenome-wide and Transcriptome-wide Analyses Reveal Gestational Diabetes is Associated with Alterations in the Human Leukocyte Antigen Complex
#> 771                                                                                        Epigenome-wide and Transcriptome-wide Analyses Reveal Gestational Diabetes is Associated with Alterations in the Human Leukocyte Antigen Complex [gene expression]
#> 772                                                                                            Epigenome-wide and Transcriptome-wide Analyses Reveal Gestational Diabetes is Associated with Alterations in the Human Leukocyte Antigen Complex [methylation]
#> 773                                                                                                                                    Expression data from insulin-treated human primary fibroblasts and effects of U0126 on insulin-induced gene expression
#> 774                                                                                                                                                          Gene Expression Profiling in Omental Adipose Tissue of Morbidly Obese Diabetic African Americans
#> 775                                                                                                                                                          Inhibition of ZEB1 expression induces redifferentiation of adult human β cells expanded in vitro
#> 776                                                                                                                                               Comparative analysis of gene expression profiles in lymphoma cells after treatment by Dexamethasone or CpdA
#> 777                                                                                                                                        Comparative analysis of gene expression profiles in prostate cancer cells after treatment by Dexamethasone or CpdA
#> 778                                                                                                                                                                                                          BisPCR2 method for targeted bisulfite sequencing
#> 779                                                                                                                                                               Gene expression annalysis of peripheral blood cells in patients with chronic kidney disease
#> 780                                                                                                                                                                  Genome-wide blood transcriptional profiling in critically ill patients - MARS consortium
#> 781                                                                                                                                                                  Cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus.
#> 782                                                                                                                                                                      Effect of type 2 diabetes on transcriptional signatures during exercise and recovery
#> 783                                                                                                                                                Differences in platelet miRNA profiles between patients with coronary artery disease and healthy controls.
#> 784                                                                                                                                                                                            miRNA regulation in diabetes associated impaired wound healing
#> 785                                                                                                                                        Novel Observations from Next Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets
#> 786                                                                                                                                                                                       A Blood Transcriptional Diagnostic Assay for Septicemic Melioidosis
#> 787                                                                                                                                                                                                                Genetic background of immune complications
#> 788                                                                                                                                                                                    Differential mRNA expression profile regulated by HNF4α in Hep3B cells
#> 789                                                                 Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretion of human abdominal subcutaneous adipocytes
#> 790                                                                                                                                                         Skeletal muscle gene expression changes with exercise mode, duration and intensity: STRRIDE study
#> 791                                                                                                                                                        caArray_beer-00153: Gene-expression profiles predict survival of patients with lung adenocarcinoma
#> 792                                                                                                                                                                                           Gene expression responses to chronic low dose arsenite exposure
#> 793                                                                                                                                  Comparative genomic, microRNA, and tissue analyses reveal subtle differences between non-diabetic and diabetic foot skin
#> 794                                                                                       Comparative genomic, microRNA, and tissue analyses reveal subtle differences between non-diabetic and diabetic foot skin [nanoString nCounter miR expression assay]
#> 795                                                                                                             Comparative genomic, microRNA, and tissue analyses reveal subtle differences between non-diabetic and diabetic foot skin [microRNA PCR panel]
#> 796                                                                                                                Comparative genomic, microRNA, and tissue analyses reveal subtle differences between non-diabetic and diabetic foot skin [gene expression]
#> 797                                                                                                                                                                       MicroRNA signature in skeletal muscle in type 2 Diabetes and insulin resistant rats
#> 798                                                                                                                                                                                          MicroRNA signature in skeletal muscle in type 2 Diabetes [human]
#> 799                                                                                                          Differential adipose tissue gene expression profiles in abacavir treated patients that may contribute to cardiovascular risk: a microarray study
#> 800                                                                                                                                                                                                 Salivary Transcriptomic Biomarkers for Insulin Resistance
#> 801                                                                                                                                                                                                         RNA-sequencing of healthy human skeletal myocytes
#> 802                                                                                                                                                                                       Transcriptome analysis of Myotonic Dystrophy type 2 (DM2) patients.
#> 803                                                                                                                                                                  Noncoding RNAs in human intervertebral disc degeneration: an integrated microarray study
#> 804                                                                                                                                                     Mitoscriptome analysis to understand the pathogenesis of Diabetic Retinopathy using tissue microarray
#> 805                                                                                                                                                               Age-associated DNA methylation changes within 5 years after birth in human blood leukocytes
#> 806                                                                                                                                           Genome-Wide Gene Expression Profiles in the Pancreatic Lymph Nodes of At-Risk Autoantibody Positive Individuals
#> 807                                                                                                                     A Whole Blood Molecular Signature for the Identification of Acute Myocardial Infarction Without Relying Upon Myonecrosis (microarray)
#> 808                                                                                                                                                 Blood methylomic signatures of pre-symptomatic dementia in elderly subjects with Type 2 Diabetes Mellitus
#> 809                                                                                                                                                                                           Genome wide analysis of copy number variation in NAFLD spectrum
#> 810                                                                                         Differential microarray expression profile analysis of long non-coding RNAs in umbilical cord vein plasma from normal and gestational diabetes-induced macrosomia
#> 811                                                                                                                                Imporatance of substantial weight loss for altering gene expression during intensive cardiovascular lifestyle modification
#> 812                                                                                                                                                                                                     miRNA expression profiling of primary melanoma tumors
#> 813                                                                                                                                                                                          miRNA expression profiling of primary melanoma tumors (cohort I)
#> 814                                                                                                             The effects of moderate weight gain in adipose tissue gene expression in metabolically-normal (MNO) and metabolically-abnormal (MAO) subjects
#> 815                                                                                                                                        Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes
#> 816                                                                                                                                                                                   Next generation sequencing of human immune cell subsets across diseases
#> 817                                                                                         MicroRNA Expression Profiles identify genes of apoptosis, anabolism and catabolism in patients with Intervertebral Disc Degeneration different from Spinal Trauma
#> 818                                                                                                                                                                           Gene expression profiling in blood of patients with chronic respiratory failure
#> 819                                                                                                                                                         Determinants of excess genetic risk of acute myocardial infarction – a matched case-control study
#> 820                                                                                                                        p38 MAPK activation upregulates pro-inflammatory pathways in skeletal muscle cells from insulin resistant type 2 diabetic patients
#> 821                                                                                                                                             Differential regulation of microRNAs in skeletal muscle from monozygotic twins discordant for type 2 diabetes
#> 822                                                                                                                                     The long noncoding RNA expression profile of human intervertebral disc degeneration identified by microarray analysis
#> 823                                                                                                                                                                                 White-to-brown metabolic conversion of human adipocytes by JAK inhibition
#> 824                                                                                                                                                                                   Gene expression profiling of myxoid liposarcomas (validation set INT-B)
#> 825                                                                                                                                                                                     Gene expression profiling of myxoid liposarcomas (training set INT-A)
#> 826                                                                                                                 Gene expression profiles of HMEC-1 after exposure to the chemotherapeutic drugs bleomycin and cisplatin with untreated samples as control
#> 827                                                                                                                                           PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies [expression array]
#> 828                                                                                                                                                   PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies [ChIP-seq]
#> 829                                                                                                                                                                                           SNP genotyping data from human iPSCs and human fibroblast cells
#> 830                                                                                                                                                                                             Generation of functional human pancreatic beta cells in vitro
#> 831                                                                                                                                                              Global mRNA/LncRNA expression analysis of pancreatic tumors causing type3C Diabetes Mellitus
#> 832                                                                                                                                                                   Exonic variants associated with development of Aspirin Exacerbated Respiratory Diseases
#> 833                                                                                                                                                  Using RNA sequencing for identifying gene imprinting and random monoallelic expression in human placenta
#> 834                                                                                                                                 Using RNA sequencing for identifying gene imprinting and random monoallelic expression in human placenta (SNP genotyping)
#> 835                                                                                                                                                               Redifferentiation of adult human β cells expanded in vitro by inhibition of the WNT pathway
#> 836                                                                                                                          Molecular and cellular characterization of Cord Blood derived, IDO expressing human fibrocystic Myeloid Derived Suppressor Cells
#> 837                                                                                                                                             Ras-induced epigenetic inactivation of RRAD promotes glucose uptake in a human ovarian cancer model [DGE-Seq]
#> 838                                                                                                                                            Ras-induced epigenetic inactivation of RRAD promotes glucose uptake in a human ovarian cancer model (RRBS-Seq]
#> 839                                                                                                                             FKBP5 expression in human adipose tissue increases following dexamethasone exposure and is associated with insulin resistance
#> 840                                                                                                                                                      Gene Expression Profile of Fibrovascular Membrane Associated with Proliferative Diabetic Retinopathy
#> 841                                                                                                                                                          Peripheral blood mononuclear cell in patients with type 1 diabetes compared with normal controls
#> 842                                                                                                                          microRNA expression data from peripheral blood mononuclear cell in patients with type 1 diabetes  compared with normal controls.
#> 843                                                                                                                                    Expression data from peripheral blood mononuclear cell in patients with type 1 diabetes  compared with normal controls
#> 844                                                                                                                                               Identification of Novel Auto-antibodies in Type 1 Diabetic Patients using a High-density Protein Microarray
#> 845                                                                                                                           Global transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism [expression array]
#> 846                                                                                                                       microRNA profiling of HepG2 cells: control vs treatment with cacao, grape seed proanthocyanidin extract or epigallocatechin gallate
#> 847                                                                                                                                                                             Human cells infected with Mucormycosis-causing strains from clinical settings
#> 848                                                                                                                                           Maternal microRNAs secreted by the endometrium act as  transcriptomic regulators of the pre-implantation embryo
#> 849                                                                                                                                                                Towards epigenetic understanding and therapy of insulin resistance by intranuclear insulin
#> 850                                                                                                                              Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks
#> 851                                                                                                                                                                              Molecular signatures differentiate immune states in Type 1 Diabetes families
#> 852                                                                                                                                 Dietary fat quality, more than dietary fat quantity, impacts genome-wide DNA methylation patterns in Greek preadolescents
#> 853                                                                                                  Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on a high-fat, high-sugar diet.
#> 854                                                   Risk of T1D progression in islet autoantibody positive children can be further stratified using expression patterns of multiple genes implicated in peripheral blood lymphocyte activation and function
#> 855                                                                                                                                            Identification of Type 1 Diabetes-Associated DNA Methylation Variable Positions That Precede Disease Diagnosis
#> 856                                                                                                                                                                                              A conditionally immortalized human pancreatic beta cell line
#> 857                                                                                                                                                                                                 Platelet micro-RNA expression in type 2 diabetes mellitus
#> 858                                                                                                                                                                               Whole Blood Transcriptional Modules generated on Illumina Hu-6 V2 Beadchips
#> 859                                                                                                                                                                           Expression microarray analysis of human pancreatic islets reveals CD59 function
#> 860                                                                                                                                                                                  Expression data of Participants of Ornish intervention and Control group
#> 861                                                                             Genome-wide expression kinetics of children with Type 1 diabetes (T1D) -associated autoantibodies or progression towards clinical T1D, compared to healthy matched controls .
#> 862                                                                                                                                                                                               Gene expression changes during Type 1 diabetes pathogenesis
#> 863                                                                                                                                                                Genome-wide espression kinetics of children progressing to clinical Type 1 diabetes (T1D).
#> 864                                                                                                                                    Genome-wide expression kinetics of children with T1D-associated autoantibodies compared to healthy matched controls II
#> 865                                                                                                                                     Genome-wide expression kinetics of children with T1D-associated autoantibodies compared to healthy matched controls I
#> 866                                                                                                                                     Differential miRNA expression profiling of urinary exosomes from normo- and microalbuminuric type 1 diabetic patients
#> 867                                                                                                                                                        Genome wide analysis of Visceral adipose tissue CD14+ cells from Obese and obese diabetic subjects
#> 868                                                                                                                                                       Prenatal arsenic exposure and the epigenome: altered gene expression profiles in newborn cord blood
#> 869                                                                                                                                                      Prenatal arsenic exposure and the epigenome: altered miRNA expression profiles in newborn cord blood
#> 870                                                                                                                                 RNA-sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate
#> 871                                                                                                                                                               gene expression Fulminant type 1 diabetes vs classical type 1A diabetes vs healthy controls
#> 872                                                                                                                                                                                   Gene expression Fulminant type 1 diabetes vs classical type 1A diabetes
#> 873                                                                                                                                                                                                                 mRNA and microRNA profile in colon cancer
#> 874                                                                                                             Complementary Strand MicroRNAs Mediate Acquisition of Metastatic Potential in Colonic AdenocarcinomamRNA and microRNA profile in colon cancer
#> 875                                                                                                                                                                                                     mRNA and microRNA profile in colon cancer [mRNA data]
#> 876                                                                                                                                                                               Impact of Visceral Fat on Gene Expression Profile in Peripheral Blood Cells
#> 877                                                                                                                          Epigenomic Approaches to explaining Metabolic Memory in the Epidemiology of Diabetes Intervention and Complications (EDIC) Study
#> 878                                                                                                                                                                                                         Human islets exposed to cytokines IL-1β and IFN-γ
#> 879                                                                                                                                             Expression of the placental transcriptome in fetal growth restriction in the Baboon is Dependent on Fetal Sex
#> 880                                                                                                                                                                            Molecular signatures of human iPSCs highlight sex differences and cancer genes
#> 881                                                                                                                                                                   Epigenetic regulation of the MEG3-DLK1 microRNA cluster in human Type 2 diabetic islets
#> 882                                                                                                                                                          DNA methylation differences between multiple sclerosis and controls in frontal lobe white matter
#> 883                                                                                                     Differential genes in adipocytes induced from polycystic ovary syndrome-derived and non- polycystic ovary syndrome-derived human embryonic stem cells
#> 884                                                                                                                                                                   Epigenetic regulation of the MEG3-DLK1 microRNA cluster in human Type 2 diabetic islets
#> 885                                                                                                                                                                     Differentially Expressed Wound Healing-Related microRNAs in the Human Diabetic Cornea
#> 886                                                                                                                                   Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants (ChIP-seq)
#> 887                                                                                                                                    Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants (RNA-seq)
#> 888                                                                                                                                            Increases in Insulin Sensitivity among Obese Youth are Associated with Gene Expression Changes in Whole Blood.
#> 889                                                                                                                                                       SBV - Gene Expression Profiles of Lung Cancer Tumors - Adenocarcinomas and Squamous Cell Carcinomas
#> 890                                                                                                                                                                Adipose tissue gene expression associated with weight gain in kidney transplant recipients
#> 891                                                                                                                                     Effects of 30 days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men
#> 892                                                                                                                                                                                            Expression data from kidney biopsies of liver disease patients
#> 893                                                                                                                                                                     DNA methylation differences between human regulatory T cells and conventional T cells
#> 894                                                                                                                                                                             Gene expression profiles in 74 laser microdissected colorectal cancer tissues
#> 895                                                                                                                                                                           Epigenomic plasticity enables human pancreatic alpha to beta cell reprogramming
#> 896                                                                                                                                                                            Expression data from open bariatric surgery patients - various adipose samples
#> 897                                                                                                                                                               Ficolin-1 is upregulated in leukocytes and glomeruli from microscopic polyangiitis patients
#> 898                                                                                                                         Differential expression profiles of human primary endothelial cells (HUVECs) from umbilical cords of Gestational Diabetic mothers
#> 899                                                                                                                  Analyses of a deactivation genetic variation in Ha-Ras proto oncogene identified in a patient wit premature aging and insulin resistance
#> 900                                                                                                                                                                         A mutation in the c-Fos gene associated with congenital generalized lipodystrophy
#> 901                                                                                                                                                       In silico nano-dissection: defining cell type specificity at transcriptional level in human disease
#> 902                                                                                                                                  In silico nano-dissection: defining cell type specificity at transcriptional level in human disease (tubulointerstitium)
#> 903                                                                                                                                           In silico nano-dissection: defining cell type specificity at transcriptional level in human disease (glomeruli)
#> 904                                                                                                                                                                        Cyclodextrin protects podocytes in diabetic kidney disease [HumanHT-12 V4.0 array]
#> 905                                                                                                                                                                                               Cyclodextrin protects podocytes in diabetic kidney disease.
#> 906                                                                                                                                                                         Cyclodextrin protects podocytes in diabetic kidney disease [HumanWG-6 v3.0 array]
#> 907                                                                                                                                                                          The Heritage (HEalth, RIsk factors, exercise Training And GEnetics) family study
#> 908                                                                                                                                                                                       miRNA-sequencing of human pancreatic islets and enriched beta-cells
#> 909                                                                                                                                 Temporal induction of immunoregulatory processes coincides with age-dependent resistance to viral-induced type 1 diabetes
#> 910                                                                                                                         Temporal induction of immunoregulatory processes coincides with age-dependent resistance to viral-induced type 1 diabetes [human]
#> 911                                                                                                                   Cluster analysis reveals differential transcript profiles associated with resistance training-induced human skeletal muscle hypertrophy
#> 912                                                                                                                                                                       Genetic Risk Factors for Type 2 Diabetes:  A Trans-Regulatory Genetic Architecture?
#> 913                                                                                                                                          A transcriptomic analysis of a Caucasian family cohort of high risks for the metabolic syndrome [HumanWG-6 v3.0]
#> 914                                                                                                                                          A transcriptomic analysis of a Caucasian family cohort of high risks for the metabolic syndrome [HumanWG-6 v2.0]
#> 915                                                                                                                                                                                               A stem cell model of diabetes due to glucokinase deficiency
#> 916                                                                                                                                                                                                               Gene expression from human pancreatic islet
#> 917                                                                                                                                                                               Transcription dependent dynamic supercoiling is a short-range genomic force
#> 918                                                                                                                                                                                Transcription dependent dynamic supercoiling in Raji human B cells in vivo
#> 919                                                                                                                                                                                                             Gene expression assay from Raji human B cells
#> 920                                                                                                                                           Gene expression profiling in endothelial precursor cells of patients protected from microvascular complications
#> 921                                                                                                                  Human transcriptome analysis of acute responses to glucose ingestion reveals a role of leukocytes in hyperglycemia induced inflammation.
#> 922                                                                                                                                                                                                                               PBEF Knockdown in HMVEC-LBI
#> 923                                                                                                                               Genome-Wide Analysis of DNA Methylation Differences in Muscle and Fat from Monozygotic Twins Discordant for Type 2 Diabetes
#> 924                                                                                                                                           The anti-inflammatory IL-1 receptor antagonist (IL-1ra) protects against the development of islet autoimmunity.
#> 925                                                                                                                                                                                                       An eQTL study in the Japanese population [genotype]
#> 926                                                                                                                                                                                              An eQTL study in the Japanese population [gene expression_3]
#> 927                                                                                                                                                                                              An eQTL study in the Japanese population [gene expression_2]
#> 928                                                                                                                                                                                              An eQTL study in the Japanese population [gene expression_1]
#> 929                                                                                                                                                                     Global Gene Expression Profiles of  Visceral Adipose in Females with Type 2 Diabetes.
#> 930                                                                                                                                                                  Global Gene Expression Profiles of Subcutaneous Adipose in Females with Type 2 Diabetes.
#> 931                                                                                                                                                                        Global Gene Expression Profiles of  Skeletal Muscle in Males with Type 2 Diabetes.
#> 932                                                                                                                                                                                Global gene expression profile of coronary artery disease in Asian Indians
#> 933                                                                                                                                                         Dynamic regulation of miRNA and mRNA signatures during in vitro pancreatic differentiation (mRNA)
#> 934                                                                                                                                                        Dynamic regulation of miRNA and mRNA signatures during in vitro pancreatic differentiation (miRNA)
#> 935                                                         Differential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance:  Identification of Susceptibility Gene Sets through Network Analysis
#> 936                                                                                                                                      Transcriptional Signatures as a Disease-Specific and Predictive Inflammatory Biomarker for Type 1 Diabetes [T1D_114]
#> 937                                                                                                                        Transcriptional Signatures as a Disease-Specific and Predictive Inflammatory Biomarker for Type 1 Diabetes [Pneu_S3S24_10Pneu_4HC]
#> 938                                                                                                                                                Transcriptional Signatures as a Disease-Specific and Predictive Inflammatory Biomarker for Type 1 Diabetes
#> 939                                                                                                                             Transcriptional Signatures as a Disease-Specific and Predictive Inflammatory Biomarker for Type 1 Diabetes [H1N1_S5_5Pre_5D0]
#> 940                                                                                                                      Transcriptional Signatures as a Disease-Specific and Predictive Inflammatory Biomarker for Type 1 Diabetes [CF_S1S3_5Auto_20CF_10HC]
#> 941                                                                                                                                                                                  microRNAs expression profile in Myotonic Dystrophy type-2 (DM2) patients
#> 942                                                                                                                                 Genomic Multivariate Predictors of Response to Adjuvant Chemotherapy in Ovarian Carcinoma: Predicting Platinum Resistance
#> 943                                                                                                                                                                           microRNA profiling of formalin-fixed, paraffin-embedded human sarcoma specimens
#> 944                                                                                                                                                                     Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming
#> 945                                                                                                                                                                                                              Expression data from human pancreatic islets
#> 946                                                                                                                                                                                                                                         Paradigm Test Set
#> 947                                                                                                                                                                                                                        Paradigm Test Set Expression Array
#> 948                                                                                                                                            Cell type-specific binding patterns reveal that TCF7L2 can be tethered to the genome by association with GATA3
#> 949                                                                                                                                                                              Dermal lymphatic endothelial cell response to type 2 diabetes [Homo sapiens]
#> 950                                                                                                                                                      Profiles of Epigenetic Histone Post-translational Modifications at Type 1 Diabetes Susceptible Genes
#> 951                                                                                                                                                                  ChIP-chip of lymphocytes using H3K9Ac, H3K4me3, H3K9me3, H3K27me3 and H4K16Ac antibodies
#> 952                                                                                                                                                                              ChIP-chip of monocytes using H3K9Ac, H3K4me3, H3K9me2 and H4K16Ac antibodies
#> 953                                                                                                                                                                                                               Gene expression data from human lymphocytes
#> 954                                                                                                                                                                                 Peripheral Blood Monocyte Gene Expression in Recent-Onset Type 1 Diabetes
#> 955                                                                                                                                                                                     Incisional hernia recurrence through genomic profiling: a pilot study
#> 956                                                                                                                                         Transcriptome analysis of circulating monocytes in obese patients before and three months after bariatric surgery
#> 957                                                                                                                                                                                   microRNA expression analysis of circulating monocytes in obese patients
#> 958                                                                                                                                                                               Evaluation of a novel clinical platform for cardiovascular drug development
#> 959                                                                                                                                                                   Mid-gestational gene expression profile in placenta and link to pregnancy complications
#> 960                                                                                                                                                                              Amorfrutins are selective PPARγ agonists with potent antidiabetic properties
#> 961                                                                                                                                   Blood biomarkers of pancreatic cancer associated diabetes identified by peripheral blood-based gene expression profiles
#> 962                                                                                                                               Genome-wide analysis of SPARC(secreted protein acidic and rich in cysteine)-responsive gene expression in HTR-8/SVneo cells
#> 963                                                                                                                                                             DNA methylation profiling of male human pancreatic islets identifies loci for type 2 diabetes
#> 964                                                                                                                                Gene expression analysis of bone biospies from nine patients with endogenous Cushings syndrome before and after  treatment
#> 965                                                                                                                                       Hyperglycemia and a Common Variant of GCKR Are Associated with the Levels of Eight Amino Acids in 9,371 Finnish Men
#> 966                                                                                                                                                                                 RNA-sequencing of TGF-ß1-driven gene expression in human kidney cell line
#> 967                                                                                                                                                                                           Expression data from cytoplasmic hybrid (cybrid) and rho0 cells
#> 968                                                                                                                                                      Transcriptome analysis of diabetic and non diabetic patients affected by post-ischemic heart failure
#> 969                                                                                                                                                                Personal Omics Profiling Reveals Dynamic Molecular Phenotypes and Actionable Medical Risks
#> 970                                                                                                                                                                                                                    Autoantibody profile timecourse of UNK
#> 971                                                                                                                                                                            The human pancreatic islet transcriptome: impact of pro-inflammatory cytokines
#> 972                                                                                                       Polyunsaturated fatty acids acutely affect triacylglycerol-derived skeletal muscle fatty acid uptake and increases postprandial insulin sensitivity
#> 973                                                                                                             Expression data from peripheral blood mononuclear cell in patients with type 1 diabetes before and after peripheral stem cell transplantation
#> 974                                                                                                                                        Differential gene expression in adipose tissue from obese human subjects during weight loss and weight maintenance
#> 975                                                                                                                                      Specific post-translational histone mod. of neutrophil extracellular traps as immunogens & potential SLE Ab targets.
#> 976                                                                                                                                                                  MicroRNAs expression profiling of human nucleus pulposus cells: control vs. degeneration
#> 977                                                                                                                                                                                                 Blood genomic expression profile for ischemic stroke (IS)
#> 978                                                                                                                                                                                Gene expression profiling in arterial tissue from type 2 diabetic patients
#> 979                                                                                                                     Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
#> 980                                                                                                                                                                                    Molecular markers of predictive value associated with low birth weight
#> 981                                                                                                                                      Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood
#> 982                                                                                                                                                                                              Human oocytes reprogram somatic cells to a pluripotent state
#> 983                                                                                                                                                                         Gene expression in blastomeres after transfer of somatic cells into human oocytes
#> 984                                                                                                                                                   Gene expression in pluripotent stem cells derived after somatic cell genome transfer into human oocytes
#> 985                                                                                                                                                          To investigate how the glycosylation of podocyte proteins changes during diabetic kidney disease
#> 986                                                                                                                                                                              Formalin Fixation at Low Temperature Better Preserves Nucleic Acid Integrity
#> 987                                                                                                                                                                                              Correlation between maternal age and newborn DNA methylation
#> 988                                                                                                                                                                            Gene expression profiles in 132 laser microdissected colorectal cancer tissues
#> 989                                                                                                                                                     A gene signature in histologically normal surgical margins is predictive of oral carcinoma recurrence
#> 990                                                                                                                                                            Transcriptome Analysis of Human Diabetic Kidney Disease (Control Glomeruli vs. Control Tubuli)
#> 991                                                                                                                                                                   Transcriptome Analysis of Human Diabetic Kidney Disease (DKD Tubuli vs. Control Tubuli)
#> 992                                                                                                                                                             Transcriptome Analysis of Human Diabetic Kidney Disease (DKD Glomeruli vs. Control Glomeruli)
#> 993                                                                                                                                                                                                   Transcriptome Analysis of Human Diabetic Kidney Disease
#> 994                                                                                                                                            Differences in subcutaneous adipose tissue gene expression between obese African Americans and Hispanic Youths
#> 995                                                                                                                                             Genome-wide mRNA profiling of adult human pancreatic beta and duct cells in comparison to other human tissues
#> 996                                                                                                                                                     Insulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro
#> 997                                                                                                                                                         HIV Infection and Antiretroviral Therapy Have Divergent Effects on Mitochondria in Adipose Tissue
#> 998                                                                                                                                                                  Expression in Huh7 cells 72 hours after treatment with scramble, SPTLC123, or DEGS siRNA
#> 999                                                                                                                                                       Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity
#> 1000                                                                                                                                                                                An early inflammatory gene profile in visceral adipose tissue in children
#> 1001                                                                                                                                         Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity (Affymetrix)
#> 1002                                                                                                                                                    Genome-wide profiling of H3K56 acetylation and transcription factor binding sites in human adipocytes
#> 1003                                                                                                                                                                              TGFß1-driven epithelial to mesenchymal transition in human kidney cell line
#> 1004                                                                                                                                                                 Comparative miRNA Expression Profiles in Individuals with Latent and Active Tuberculosis
#> 1005                                                                                                                             Transcriptome profile of peripheral blood mononuclear cells in patients with type I diabetes and their first grade relatives
#> 1006                                                                                                                                                                                                 Expression Data from HNF4a RNAi Knockdown in HepG2 cells
#> 1007                                                                                                                                                     Increased SRF Transcriptional Activity is a Novel Signature of Insulin Resistance in Humans and Mice
#> 1008                                                                                                                                                    Mapping of INS promoter interactions reveals its role in long-range  regulation of SYT8 transcription
#> 1009                                                                                                       Dioxin exposure of human CD34+ hemopoietic cells induces gene expression modulation that recapitulates its in vivo clinical and biological effects
#> 1010                                                                                                                                                                                                           Adenosine-treated endothelial progenitor cells
#> 1011                                                                                                                                      Resolution of Type 2 Diabetes Following Bariatric Surgery is Associated with Changes in Whole Blood Gene Expression
#> 1012                                                                                                                           Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans
#> 1013                                                                                                                                                             Genomic expression profiles of blood and placenta in Chinese women with gestational diabetes
#> 1014                                                                                                                                                                                                       Type 2 Diabetes mellitus: mRNA and miRNA profiling
#> 1015                                                                                                                          MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in Type 2 Diabetes mellitus
#> 1016                                                                                                                                                                                                     DNA methylation patterns associated with arsenicosis
#> 1017                                                                                                                                                                                               Investigation of somatic copy number variation in MZ twins
#> 1018                                                                                                                                                                              Expression data from type 2 diabetic and non-diabetic isolated human islets
#> 1019                                                                                                                                                   Methylated DNA Immunoprecipitation (MeDIP) using a custom type 2 diabetes and related phenotypes array
#> 1020                                                                                                                                                                      Effect of insulin on the stromal and adipocyte cells within hMSC derived adipocytes
#> 1021                                                                                                                                                                                           Skeletal muscle mitochondrial dysfunction is secondary to T2DM
#> 1022                                                                                                                                     Genome-wide binding of the orphan nuclear receptor TR4 suggests its general role in fundamental biological processes
#> 1023                                                                                                                                    BI Human Reference Epigenome Mapping Project: Characterization of chromatin modification by ChIP-Seq in human subject
#> 1024                                                                                                                                 Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci
#> 1025                                                                                                                                                                                   Analysis of transcriptome in ectopic versus orthotopic thyroid tissue.
#> 1026                                                                                                                                                                       microRNA and mRNA expression profiles of human pancreatic islet-like cell clusters
#> 1027                                                                                                                                                                              Sural nerve of progressive and non-progressive diabetic neuropathy patients
#> 1028                                                                                                                    Insulin resistance induced by physical inactivity is associated with multiple transcriptional changes in skeletal muscle in young men
#> 1029                                                                                                                                                                                     Sera-induced transcriptional signatures in human leukemia cell lines
#> 1030                                                                                                                                              DNA methylation data from non-immortalized lymphocyte samples from participants of the AGES Reykjavik Study
#> 1031                                                                                                                                             Peripheral blood gene expression profiles in metabolic syndrome, coronary artery disease and type 2 diabetes
#> 1032                                                                                                                                    Phenothiazine Neuroleptics Signal To The Human Insulin Promoter As Revealed By A Novel Human b-Cell Line Based Screen
#> 1033                                                                                                                                                                                                  Human lung squamous cell carcinoma expression profiling
#> 1034                                                                                                                                                        Gene expression changes in Peripheral Blood Mononuclear cells (PBMC) induced by physical activity
#> 1035                                                                                                                                 Effect of IL6 level on gene expression changes in Peripheral Blood Mononuclear cells (PBMC) induced by physical activity
#> 1036                                                                                                                                                                                         Expression data from human liver with or without type 2 diabetes
#> 1037                                                                                                                                                                                                  Systematic analysis of a human renal transcript dataset
#> 1038                                                                                                                                                                                                               Expression data from human skeletal muscle
#> 1039                                                                                                                                                                    Transcriptional response in human umbilical vein endothelial cells exposed to insulin
#> 1040                                                                                                                                                                                                   miRNA expression profile of human subcutaneous adipose
#> 1041                                                                                                                                                          Blood microRNA profiles and upregulation of hsa-miR-144 in males with type 2 diabetes mellitus.
#> 1042                                                                                                                                        A Transcriptional Signature and Common Gene Networks Link Cancer with Metabolic Syndrome and Auto-immune Diseases
#> 1043                                                                                                                                                       Human skeletal muscle - type 2 diabetes and family history positive individuals - Mexican American
#> 1044                                                                                                                                                      Expression levels in immortalized B cells from unrelated individuals and twins undergoing ER stress
#> 1045                                                                                                                       Gene expression profiles of beta-cell enriched tissue obtained by Laser Capture Microdissection from subjects with type 2 diabetes
#> 1046                                                                                                                                                                Genome wide DNA methylation profiling of diabetic nephropathy in type 1 diabetes mellitus
#> 1047                                                                                                                                            A restricted repertoire of cytosine methylation changes in neonates following intrauterine growth restriction
#> 1048                                                                                                                                                            C-peptide and/or transforming growth factor beta 1 effect on human proximal tubular cell line
#> 1049                                                                                                                                                                                             mRNA expression data from skeletal muscle of type 2 diabetes
#> 1050                                                                                                                                                         miRNA expression signatures for human stomach biopsy samples, H. pylori positive versus negative
#> 1051                                                                                                                                                                                       University of Washington Human Reference Epigenome Mapping Project
#> 1052                                                                                                                                        Preadipocytes of T2DM patients display an intrinsic gene expression profile of decreased differentiation capacity
#> 1053                                                                                                                                     Folic acid supplementation normalizes the endothelial progenitor cell transcriptome of patients with type 1 diabetes
#> 1054                                                                                                                                                               Differential Expression of MicroRNAs in Mouse Liver under Aberrant Energy Metabolic Status
#> 1055                                                                                                                                                                 Mitochondrial dysregulation and oxidative stress in patients with chronic kidney disease
#> 1056                                                                                                                                                  Stable Patterns of Gene Expression Regulating Carbohydrate Metabolism Determined by Geographic Ancestry
#> 1057                                                                                                                                                                                              THE EFFECTS OF ALCOHOLISM ON THE HUMAN BASOLATERAL AMYGDALA
#> 1058                                                                                                                                               Gene expression analysis of chronically inflamed human peri-implant and periodontal ligament cells in vivo
#> 1059                                                                                                                                                                               Thrombospondin-1: A Pro-Atherosclerotic Protein Augmented by Hyperglycemia
#> 1060                                                                                                                                                                                                           UCSD Human Reference Epigenome Mapping Project
#> 1061                                                                                                                                                                               Meta analysis of gene expression in human islets after in vitro expansion.
#> 1062                                                                                                                                                                   Expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes
#> 1063                                                                                                                                                             MiRNA expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes
#> 1064                                                                                                                                                                                                                 miRNA prognostic profiles in lung cancer
#> 1065                                                                                                                                     Genomic Transcriptional Profiling Identifies a Blood Biomarker Signature for the Diagnosis of Septicemic Melioidosis
#> 1066                                                                                                                                                   A synthetic gene-metabolic circuit preferentially increased fatty acid metabolism in human hepatocytes
#> 1067                                                                                                                                                            Genome wide gene expression profiling of visceral adipose tissue among Asian Indian diabetics
#> 1068                                                                                                                                                           Expression data from liver of obese (with or without type 2 diabetes) and lean human subjects.
#> 1069                                                                                                                                                                                           Gene expression of innate immune response in endothelial cells
#> 1070                                                                                                                                                              Acetaminophen-induced gene expression profiles in sandwich-cultured primary rat hepatoctyes
#> 1071                                                                                                                                                                                                   MicroRNA expression profiling in diabetic GK rat model
#> 1072                                                                                                                                                                                                  Transcriptomes in Healthy and Diseased Gingival Tissues
#> 1073                                                                                                                                                                                                Circulating Cells in Coronary Collateral Artery Growth II
#> 1074                                                                                                                                                                          Gene expression profiling in skeletal muscle of PCOS after pioglitazone therapy
#> 1075                                                                                                                                                                                   Transcription profiling of myotubes from patients with type 2 diabetes
#> 1076                                                                                                                                                                                  Construction of a modular analysis framework for blood Genomics Studies
#> 1077                                                                                                                                                     A Modular Analysis Framework for Blood Genomics Studies: Application to Systemic Lupus Erythematosus
#> 1078                                                                                                                                     Transcriptional changes in blood from metabolic syndrome patients after a period of high intensity interval training
#> 1079                                                                                                                                                                                       Mapping the Genetic Architecture of Gene Expression in Human Liver
#> 1080                                                                                                                                            Profiling Gene Expression in Human Placentae of Different Gestational Ages: an OPRU Network and UW SCOR Study
#> 1081                                                                                                                                                      Gene expression data on human optic nerve head astrocytes in normal Caucasian and African americans
#> 1082                                                                                                                                                                                 Expression profiles of peripheral blood monocytes in periodontal therapy
#> 1083                                                                                                                                                                                                    gene expression in monkey aorta with aging and gender
#> 1084                                                                                                                                                     Reduced expression of mitochondrial oxidative metabolism genes in skeletal muscle of women with PCOS
#> 1085                                                                                                                                               Expression profiling of human adipose tissue in obese and lean subjects and in various clinical conditions
#> 1086                                                                                                                                                                     Expression profile of human preadipocytes cultured with activated macrophages medium
#> 1087                                                                                                                                                         Effect of Acute Physiologic Hyperinsulinemia on Gene Expression in Human Skeletal Muscle in vivo
#> 1088                                                                                                                                                                                                     Gene expression in PBMCs from children with diabetes
#> 1089                                                                                                                                    Myocardial gene expression of hibernating and control tissue from patients with ischemic left ventricular dysfunction
#> 1090                                                                                                                                                                Specific inhibition of p300-HAT alters Global Gene Expression and Repress HIV replication
#> 1091                                                                                                                                                                                                      Effect of insulin infusion on human skeletal muscle
#> 1092                                                                                                                                                                      Changes in transcription profile in pelvic organ fibroblasts in response to stretch
#> 1093                                                                                                                                                               Dysregulation of the circulating and tissue-based renin-angiotensin system in preeclampsia
#> 1094                                                                                                                                                                    Effects of laughter on gene expression profiles patients with type 2 diabetes (Tenri)
#> 1095                                                                                                                                                                          Comparison of expression profile between human Müller cells, HMCL-I and HMCL-II
#> 1096                                                                                                                                                                         Effects of laughter on gene expression profiles of patients with type 2 diabetes
#> 1097                                                                                                                                                                                                                        PCOS patients vs control subjects
#> 1098                                                                                                                                                                                                              Skeletal muscle and insulin regulated genes
#> 1099                                                                                                                                          Target genes of the transcription factors HNF1beta and HNF1alpha in the human embryonic kidney cell line HEK293
#> 1100                                                                                                                                                                 Gene Expression Signature Shared in Autoimmune Diseases Not in Unaffected Family Members
#> 1101                                                                                                                                                                                                        Comparative profiling in 13 muscle disease groups
#> 1102                                                                                                                                                                                                                                   Colon cancer profiling
#> 1103                                                                                                                                                                Gestational Diabetes Induces Placental Genes for Chronic Stress and Inflammatory Pathways
#> 1104                                                                                                                                                                                 laughter regulates postprandial blood glucose levels and gene expression
#> 1105                                                                                                                                                                                                                                     Diabetic nephropathy
#> 1106                                                                                                                                                                                                            Muscle - atypical diabetes protein expression
#> 1107                                                                                                                                                                                                                   Type 2 diabetes and insulin resistance
#>                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Summary
#> 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Genome-wide DNA methylation profiling of bead-enriched total monocytes collected from Native Hawaiian participants with known type 2 diabetes mellitus enrolled in a 3 month diabetes-specific social support education intervention. DNA methylation profiling was performed across ~450,000 CpGs from monocytes using the Illumina Infinium HumanMethylation450 BeadChip. Samples included 8 participants with paired DNA methylation data collected at pre-intervention and post-intervention (3 months), and 2 non-diabetic donors.
#> 2                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                We identified lncRNA expression profiles in vitreous samples between proliferative diabetic retinopathy (PDR) patients and idiopathic macular hole (IMH) patients, and between PDR patients who had received preoperative anti-vascular endothelial growth factor (anti-VEGF) therapy and PDR patients who had received surgery alone. There had been the systemic expression differences in vitreous at the microarray level from PDR patients and IMH patients, and from PDR patients after anti-VEGF treatment and untreated PDR patients.
#> 3                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Cardiovascular disease (CVD) accounts for the majority of deaths in patients with type 1 diabetes (T1D); however, the determinants of plaque composition are unknown in this population. MicroRNAs (miRNAs), the most abundant class of circulating small non-coding RNA (sncRNAs) regulating gene expression, participate in the development of atherosclerosis and represent promising biomarkers of CVD.  This study analyzed the circulating miRNA expression profile in T1D with carotid calcified and fibrous plaque. more...
#> 4                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               Studies in genetically identical individuals indicate that as much as 50% of complex trait variation cannot be traced to either genetics or to the environment. The mechanisms that generate this ‘unexplained’ phenotypic variation (UPV) remain largely unknown. Here, we identify neuronatin (NNAT) as a conserved factor that buffers against unexplained phenotypic variation. We find that Nnat deficiency in isogenic F1 mice triggers the emergence of a novel, bi-stable polyphenism, where isogenic littermates emerge into adulthood either ‘normal’ or ‘overgrown’, without intermediates. more...
#> 5                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               Non-alcoholic fatty liver disease is continuum of disorders among which non-alcoholic steatohepatitis (NASH) is particularly associated with a negative prognosis. Hepatocyte lipotoxicity is one of the main pathogenic factors of liver fibrosis and NASH. However, the molecular mechanisms regulating this process are poorly understood. Here, we integrated transcriptomic and chromatin accessibility analyses from human liver and mouse hepatocytes to identify lipotoxicity-sensitive transcription factors. more...
#> 6                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               Non-alcoholic fatty liver disease is continuum of disorders among which non-alcoholic steatohepatitis (NASH) is particularly associated with a negative prognosis. Hepatocyte lipotoxicity is one of the main pathogenic factors of liver fibrosis and NASH. However, the molecular mechanisms regulating this process are poorly understood. Here, we integrated transcriptomic and chromatin accessibility analyses from human liver and mouse hepatocytes to identify lipotoxicity-sensitive transcription factors. more...
#> 7                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             Mechanistic insights into the molecular events by which exercise enhances the skeletal muscle phenotype are lacking, particularly in the context of type 2 diabetes. Here we unravel a fundamental role for exercise-responsive cytokines (exerkines) on skeletal muscle development and growth in individuals with normal glucose tolerance or type 2 diabetes. Acute exercise triggered an inflammatory response in skeletal muscle, concomitant with an infiltration of immune cells. more...
#> 8                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Metformin is one of the first-line drugs for clinical treatment of type II diabetes, and recent studies have found that metformin can inhibit the development of multiple malignant tumors. When metformin is combined with chemotherapeutic drugs to treat head and neck squamous cell carcinoma(HNSCC), it can effectively enhance the efficacy of chemotherapy. The aim of this study was to define the signaling pathways regulated by metformin in HNSCC, and the underlying mechanisms by which metformin sensitizes HNSCC chemotherapy. more...
#> 9                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       We investigate the effects of GLP-1 on diabetic cardiomyocytes (DCMs) model established by human induced pluripotent stem cells-derived cardiomyocytes (iPSC-CMs). Two subtypes of GLP-1, GLP-17-36 and GLP-19-36, were evaluated for their efficacy on hypertrophic phenotype, impaired calcium homeostasis and electrophysiological properties. RNA-seq was performed to reveal the underlying molecular mechanism of GLP-1. more...
#> 10                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         Epigenetics was reported to mediate the effects of environmental risk factors on disease pathogenesis. To unleash the role of DNA methylation modification in the pathological process of cardiovascular diseases in diabetes, we screened differentially methylated genes by methylated DNA immunoprecipitation chip (MeDIP-chip) among the enrolled participants.
#> 11                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             Aims: Metformin is a widely used, primary drug of choice to treat individuals with type 2 diabetes (T2D). Clinically, inter-individual variability of drug response is of significant  concern. The targets and precise mechanisms of action for metformin is still under interrogation. In the present study, a whole transcriptome analysis was performed with an  intent to identify predictive biomarkers of metformin response in T2D individuals. more...
#> 12                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 To understand the role of adipose tissue senescence in NAFLD/NASH,  RNA sequencing was performed in the visceral adipose tissue of NAFLD and NASH pateints.
#> 13                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 Single-cell transcriptomes of corpus cavernosum from three males with normal erections and five organic erectile dysfunction (ED) patients.
#> 14                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   Gestational diabetes mellitus (GDM) “program” an elevated risk of metabolic syndrome in the offspring.  Epigenetic alterations are a suspected mechanism. GDM has been associated with placental DNA methylation changes in some epigenome-wide association studies. It remains unclear which genes or pathways are affected, and whether any placental differential gene methylations are correlated to fetal growth or circulating metabolic health biomarkers. more...
#> 15                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Adipocytes are key regulators of human metabolism, and their dysfunction in insulin signaling is central to metabolic diseases including type II diabetes mellitus (T2D). However, the progression of insulin resistance into T2D is still poorly understood. This limited understanding is due, in part, to the dearth of suitable models of insulin signaling in human adipocytes. Traditionally, adipocyte models fail to recapitulate in vivo insulin signaling, possibly due to exposure to supraphysiological nutrient and hormone conditions. more...
#> 16                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         In this dataset, we utilized the db/db, uninephrectomy and renin-hypertension mouse model. We performed bulk RNA-seq and compared vehicle to ACE inhibitor, Rosiglitizone, SGLT2 inhibitor, ACEi + Rosiglitizone and ACEi + SGLT2i at two time points (2 days and 2 weeks). To study the mechanism, we also performed bulk RNA-seq on human primary tubular epithelial cells with or without SRSF7 siRNA knockdown.
#> 17                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      To reveal the expression profiles of transfer RNA-derived small RNA (tsRNA)s and microRNA (miRNA)s in the vitreous humour of proliferative diabetic retinopathy (PDR).
#> 18                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       Objectives: This study was undertaken to understand the mechanistic basis of response to anti-TNF therapies and determine if transcriptomic changes in the synovium are reflected in peripheral protein markers. Methods: Synovial tissue from 46 RA patients was profiled with RNA sequencing before and 12 weeks after treatment with anti-TNF therapies.  Pathway and gene signature analyses were performed on RNA expression profiles of synovial biopsies to identify mechanisms that could discriminate among EULAR good, moderate and non-responders. more...
#> 19                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Abnormal mechanical load is a main risk factor of intervertebral disc degeneration (IDD), and cellular senescence is a pathological change in IDD. Additionally, extracellular matrix (ECM) stiffness promotes human nucleus pulposus cells (hNPCs) senescence. However, the molecular mechanism underlying mechano-induced cellular senescence and IDD progression is not yet fully elucidated. First, we demonstrated that mechano-stress promoted hNPCs senescence via NF-κB signaling. more...
#> 20                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Patients with NEUROGENIN3 mutations have enteric endocrinopathy and diabetes mellitus. We generated pluripotent stem cells from a patient’s fibroblasts to investigate if gene editing restores endocrine differentiation. Corrected cell lines differentiated into all pancreatic lineages while native cell lines failed to activate pancreatic progenitor and lineage determination genes, suggesting that the mutation disrupts pancreatic organogenesis and results in endocrine and exocrine dysfunction. more...
#> 21                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Among 226 morbidly obese patients who underwent gastric bypass surgery between 2013 and 2014 as part of the A Biological Atlas of Severe Obesity (ABOS) study (ClinicalTrials.gov; NCT01129297), 18 women who gave informed consent were recruited in this study for immunophenotyping and microarray analyses of omental adipose tissue (AT). We characterized T and NK cell populations in omental AT from morbidly obese women with varying levels of IR. more...
#> 22                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Objective: To explore the characteristics and underlying molecular mechanisms of genome-scale expression profiles of women with- or without- GDM and their offspring.  Materials and Methods: We recruited a group of 21 pregnant women with GDM and 20 healthy pregnant women as controls. For each pregnant women, RNA-seq were performed using the placenta and paired neonatal umbilical cord blood specimens. more...
#> 23                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           Objective: To explore the characteristics and underlying molecular mechanisms of genome-scale expression profiles of women with- or without- gestational diabetes mellitus and their offspring.  Materials and Methods: We recruited a group of 21 pregnant women with gestational diabetes mellitus (GDM) and 20 healthy pregnant women as controls. For each pregnant women, RRBS were performed using the placenta and paired neonatal umbilical cord blood specimens. more...
#> 24                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 This SuperSeries is composed of the SubSeries listed below.
#> 25                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          To systemically investigate the role of ZnT8 in β cell maturation, we performed single cell RNA-seq in both WT and KO β cells at both S6 (immature) and S7 (mature) stages.  Both WT and KO β cells were obtained from FACS as positive for both INS and NKX6.1. Single cell RNA-seq results revealed that SLC30A8 is mainly involved in β cell maturation process, and further showed that SLC30A8 LOF accelerates β cell maturation and upregulates insulin secretion pathway in mature β cells.
#> 26                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      The antisense non-coding RNA in the INK locus (ANRIL), which originates from the CDKN2A/B (INK4-ARF) locus, has been identified as a hotspot for genetic variants associated with cardiometabolic disease including coronary artery disease (CAD) and Type 2 diabetes (T2D). We recently found that ANRIL abundance in human pancreatic islets was increased in donors carrying certain T2D risk-SNPs, and that a T2D risk-SNP located within exon2 of ANRIL conferred reduced beta cell proliferation index, pointing to a role for ANRIL in the regulation of T2D pathogenicity via an impact on insulin secretory capacity. more...
#> 27                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Long noncoding RNAs (lncRNAs) are involved in diabetes related diseases. However, the role of lncRNAs in the pathogenesis of type 2 diabetes with macrovascular complication (DMC) has seldomly been recognized. This study screened lncRNA profiles of leukocytes from DMC patients and explored protective role of lncRNA LYPLAL1-DT in endothelial cells (EC) under high glucose (HG) and inflammatory conditions (IS). more...
#> 28                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 This SuperSeries is composed of the SubSeries listed below.
#> 29                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and post-operative atrial fibrillation (POAF) is a major healthcare burden, contributing to an increased risk of stroke, kidney failure, heart attack and death. Genetic studies have identified associations with AF, but no molecular diagnostic exists to predict POAF based on pre-operative measurements. Such a tool would be of great value for perioperative planning to improve patient care and reduce healthcare costs. more...
#> 30                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and post-operative atrial fibrillation (POAF) is a major healthcare burden, contributing to an increased risk of stroke, kidney failure, heart attack and death. Genetic studies have identified associations with AF, but no molecular diagnostic exists to predict POAF based on pre-operative measurements. Such a tool would be of great value for perioperative planning to improve patient care and reduce healthcare costs. more...
#> 31                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        We profiled manually microdissected tubulointerstitial tissue from 43 IgA nephropathy, 3 diabetes mellitus nephropathy, 3 focal segmental glomerulosclerosis, 3 lupus nephritis, 4 membranous nephropathy, and 9 minimal change disease biopsy cores and 22 nephrectomy controls by RNA sequencing. The 3 outliers which were not included in our main analysis were also uploaded in this database.
#> 32                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Serum miRNAs could be powerful classifiers for the detection of patients with postmenopausal osteoporosis.
#> 33                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            The pancreas and liver arise from a common pool of progenitors in the foregut endoderm; however, the underlying molecular mechanisms driving this lineage diversification are not fully understood. We combined human pluripotent stem cell guided differentiation and sequential CRISPR-Cas9 loss-of-function screening to uncover regulators of  pancreatic specification. Here we report the discovery of a cell-intrinsic requirement for HHEX, a transcription factor (TF) associated with diabetes susceptibility. more...
#> 34                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            The pancreas and liver arise from a common pool of progenitors in the foregut endoderm; however, the underlying molecular mechanisms driving this lineage diversification are not fully understood. We combined human pluripotent stem cell guided differentiation and sequential CRISPR-Cas9 loss-of-function screening to uncover regulators of  pancreatic specification. Here we report the discovery of a cell-intrinsic requirement for HHEX, a transcription factor (TF) associated with diabetes susceptibility. more...
#> 35                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   The pancreas and liver arise from a common pool of progenitors in the foregut endoderm; however, the underlying molecular mechanisms driving this lineage diversification are not fully understood. We combined human pluripotent stem cell guided differentiation and sequential CRISPR-Cas9 loss-of-function screening to uncover regulators of pancreatic specification. Here we report the discovery an unexpected, cell-intrinsic requirement for HHEX, a transcription factor (TF) associated with diabetes susceptibility. more...
#> 36                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Every year, about 18 million babies are born from mothers with gestational diabetes mellitus (GDM). While diabetic symptoms usually resolve after delivery, lasting complications can occur for both mother and child, including fetal overgrowth, type 2 diabetes (T2D), cardiovascular diseases, and obesity. The rapid progression of GDM is unique to pregnancies, and likely arises from placental dysfunction. more...
#> 37                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Regenerating pancreatic b-cells is a potential curative approach for diabetes. We previously identified the small molecule CID661578 as a potent inducer of b-cell regeneration but its target and mechanism of action have remained unknown. We now screened 257 million yeast clones and determined that CID661578 targets MAP kinase-interacting serine/threonine kinase 2 (MNK2), an interaction that was genetically validated in vivo. more...
#> 38                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         We have reported differntial abundance of miRNAs present in the secretory Extracellular vesicles during Gestetional Diabetes Mellitus or Ischemic placental disease
#> 39                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           The aim of this study was to conduct a baseline comparison of serum-circulating miRNA in diabetic patients with and without ischemic heart disease. We analysed the expression levels of 798 serum miRNAs using the NanoString nCounter Technology Platform. The prediction of the putative miRNAs targets was performed by the Ingenuity Pathway Analysis (IPA) software. Receiver operating characteristic (ROC) analysis was used to assess the diagnostic value of identified miRNAs. more...
#> 40                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              We performed RNA-seq on tissue biopsies derived from patients with DFU and compared it to healthy controls who had similar foot surgery to identify the significant immune related differentially expressed genes between normal and DFU samples. Our results identified that there was a total of 8800 DEGs detected by RNA-seq data analysis, among which 2351 were upregulated and 6449 downregulated genes in DFU. more...
#> 41                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Studies of monogenic diabetes are particularly useful as we can gain insight into the molecular events of pancreatic β-cell failure. Maturity-onset diabetes of the young 1 (MODY1) is a monogenic diabetes form, caused by a mutation in the HNF4A gene. Human induced pluripotent stem cells (hiPSC) provide an excellent tool for disease modelling by subsequent directed differentiation toward desired pancreatic islet cells, but cellular phenotypes in terminally differentiated cells are notoriously difficult to detect. more...
#> 42                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       Background:  Long-term complications of type 2 diabetes (T2D) are the major causes for T2D-related disability and mortality. Notably, diabetic nephropathy (DN) has become the most frequent cause of end-stage renal disease (ESRD) in most countries. Understanding epigenetic contributors to DN can provide novel insights into this complex disorder and lay the foundation for more effective monitoring tools and preventive interventions, critical for achieving the ultimate goal of improving patient care and reducing healthcare burden.
#> 43                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Diabetic kidney disease (DKD) is the leading cause of both chronic kidney disease (CKD) and end-stage renal disease (ESRD). In this study, we performed transcriptome gene expression profiling of kidney tissues in human renal proximal epithelial tubular cell line (HK-2) treated with high D-glucose (HG) for 7 days before the addition of 40 mM oxamate for a further 24 hours in the presence of HG. Afterwards, we analyzed the differentially expressed (DE) genes and investigated gene relationships based on weighted gene co-expression network analysis (WGCNA). more...
#> 44                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Background: Pre-diabetes condition precedes the Diabetes Mellitus (DM) disease and is a critical period for hyperglycemia treatment, especially for menopausal women, considering all metabolic alterations due to hormonal changes. Recently, the literature has demonstrated the role of physical exercise in epigenetic reprogramming to modulate the gene expression patterns of metabolic conditions, such as hyperglycemia, preventing DM development. more...
#> 45                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              To investigate whether aberrant lncRNA expression in the placenta is involved in the pathogenesis of NDFMS and to elucidate its biological mechanisms. The expression profile of lncRNAs in the placentas of pregnant women with NDFMS was investigated using an Agilent Human LncRNA Microarray. Differentially expressed lncRNAs were selected for validation using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). 
#> 46                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 Dysregulated neurite outgrowth and synapse formation underlie many psychiatric disorders. Wolfram syndrome (WS) mainly caused by WFS1 deficiency is a monogenic genetic disease manifested by severe psychiatric disorders. Due to athe lack of proper human disease models, the underlying mechanism is poorly understood. Particularly, whether and how WFS1 deficiency affects synapse formation remain elusive. more...
#> 47                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 This SuperSeries is composed of the SubSeries listed below.
#> 48                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Type 1 diabetes (T1D) usually has a preclinical phase identified by the presence of circulating autoantibodies to pancreatic islet antigens, and most young children who have multiple autoantibodies progress to diabetes within 10 years. While autoantibodies denote underlying islet autoimmunity, how this process is initiated and then progresses to clinical diabetes on a background of genetic susceptibility is not clearly understood. more...
#> 49                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Type 1 diabetes (T1D) usually has a preclinical phase identified by the presence of circulating autoantibodies to pancreatic islet antigens, and most young children who have multiple autoantibodies progress to diabetes within 10 years. While autoantibodies denote underlying islet autoimmunity, how this process is initiated and then progresses to clinical diabetes on a background of genetic susceptibility is not clearly understood. more...
#> 50                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               Microglia are the tissue-resident macrophages of the retina and brain, being critically involved in organ development, tissue homeostasis, and response to cellular damage. Until now, little is known about the transcriptional profile of human retinal microglia and how they differentiate from peripheral monocytes, as well as from brain microglia. Additionally, the degree to which mice are suitable models for human retinal microglia is still not clear. more...
#> 51                             BACKGROUND.  The incidence of Type 1 Diabetes (T1D) has significantly increased in recent decades and coincides with lifestyle changes that have likely altered the composition of the gut microbiota.  Dysbiosis and gut barrier dysfunction are associated with T1D, and notably, our studies have identified an inflammatory state in T1D families that is consistent microbial antigen exposure.     METHODS.  We conducted a 6-week, single-arm, open-label trial to investigate whether daily multi-strain probiotic (Bifidobacteria, Lactobacillus, and Streptococcus) supplementation could reduce the familial inflammatory state in 25 unaffected siblings of diabetes patients.    RESULTS.  Probiotic supplementation was found safe and well-tolerated; there were no adverse events and participant adherence was 93%.  Bacterial 16S rDNA gene sequencing of stool revealed that community alpha and beta diversity were not altered between the pre- and post-supplement samplings.  LEfSe analyses identified post-supplement enrichment of the family Lachnospiraceae, producers of the anti-inflammatory short chain fatty acid butyrate.  Systemic inflammation was measured by plasma induced transcription and quantified with a gene ontology-based composite inflammatory index (I.I.com).  After supplementation, I.I.com was reduced (p=0.017), and pathway analysis predicted inhibition of IL17A, lipopolysaccharide, NFkB, IL1B, and TNF (Z-score≤-2.0) and activation of IL10RA (Z-score=2.0).  Post-supplement plasma levels of IL12p40, IL-13, IL-15, IL-18, CCL2, CCL24 were reduced (p<0.05), while butyrate levels trended 2.4-fold higher (p=0.06).    CONCLUSION.  There is a substantial need for safe, broadly applicable therapies to reduce T1D susceptibility.  This study indicates that investigations of prebiotic and probiotic strategies are warranted as they may be efficacious either alone or in combination with other therapeutic agents.
#> 52                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          We used the latest technology, BD Rhapsody, to analyze the pairing of α and β chains that constitute the TCR of PBMCs from patients with type 1 diabetes at the single-cell level.
#> 53                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Background: Despite the established relation between energy restriction and metabolic health, the most beneficial nutrient composition of a weight-loss diet is still subject of debate. Objectives: The aim of the study was to examine the additional effects of nutrient quality on top of energy restriction(ER). Methods: A parallel-designed 12-week 25%ER dietary intervention study was conducted. Participants aged 40-70 years with abdominal obesity were randomized over three groups: a 25%ER high nutrient quality diet (n = 40); a 25%ER low nutrient quality diet (n = 40); or a habitual diet (n = 30). more...
#> 54                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       The ability to detect and target β cells in vivo can drastically refine the way diabetes is studied and treated. By an unsupervised Systematic evolution of ligands by exponential enrichment (SELEX) we identified two RNA aptamers  that specifically recognize mouse and human β cells in vitro and in vivo.  Here we took advantage of commercially available high density protein arrays to identify putative target of the two islet specific aptamers. more...
#> 55                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Bariatric surgery mediated weight loss has been shown to significantly reduce breast cancer incidence in women. We hypothesize that loss of excessive adiposity, reduces net Estrogen Receptor Alpha activation which in turn lowers breast cancer risk. A differential gene expression analysis and subsequent pathway enrichment analysis would reveal the relevant molecular mechanism behind the preventive effect of weight loss. more...
#> 56                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Colorectal cancer (CRC) is one of the most frequently diagnosed and lethal malignancy. Several key factors including poor dietary habits, smoking, alcohol consumption, genetic predisposition, obesity, diabetes mellitus, and sedentary lifestyle – all result in a significantly increased risk for developing CRC. Current treatment modalities for patients with CRC include surgery, which is often followed with adjuvant chemotherapy, especially in patients with a stage II and III disease. more...
#> 57                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          We used WGCNA to construct a co‐expression network and obtain modules related to blood glucose, thus detecting key lncRNAs, and providing a reference for searching potential biomarkers of prediabetes and T2DM in hypertriglyceridemia patients.
#> 58                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   A rare truncating p. Arg138* variant (R138X) in zinc transporter is associated with a 65% reduced risk for type 2 diabetes. To address the mechanism of how this variant protects from type 2 diabetes, we derived human pluripotent stem cells carrying this mutation and differentiated them into insulin-producing cells. We found that human pluripotent stem cells with R138X mutation and the null mutation have normal efficiency of differentiation towards insulin-producing cells, but these cells were depleted of zinc and presented large diffused insulin granules. more...
#> 59                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  This study aimed to identify the crucial molecules and explore the function of noncoding RNAs and related pathways in IDD. We randomly selected 3 samples each from an IDD and a spinal cord injury group (control) for RNA-sequencing. We identified 463 differentially-expressed long noncoding RNAs (lncRNAs), 47 differentially-expressed microRNAs (miRNAs), and 1,334 differentially-expressed mRNAs in IDD. more...
#> 60                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Proteinuria, the spillage of serum proteins into the urine, is a feature of glomerulonephritides, podocyte disorders and diabetic nephropathy. However, the response of tubular epithelial cells to serum protein exposure has not been systematically characterized. Using transcriptomic profiling we studied serum-induced changes in primary human tubular epithelial cells cultured in 3D microphysiological devices. more...
#> 61                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Proteinuria, the spillage of serum proteins into the urine, is a feature of glomerulonephritides, podocyte disorders and diabetic nephropathy. However, the response of tubular epithelial cells to serum protein exposure has not been systematically characterized. Using transcriptomic profiling we studied serum-induced changes in primary human tubular epithelial cells cultured in 3D microphysiological devices. more...
#> 62                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             Non-mesenchymal pancreatic cells are a potential source for cell replacement therapies aiming to restore the endocrine capacity lost during diabetes mellitus. Although a highly complex network of transcription factors underlies the differentiation, growth, and specification of pancreatic precursors, several studies indicated that the transdifferentiation of non-mesenchymal cells can be achieved by epigenetic regulation. more...
#> 63                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 This SuperSeries is composed of the SubSeries listed below.
#> 64                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Pluripotent stem cell-derived islets (hPSC-islets) are a promising cell resource for diabetes treatment. Here, we demonstrate that transplantation of pluripotent stem cell-derived islets into diabetic nonprimates effectively restored endogenous insulin secretion and improved glycemic control. Single-cell RNA sequencing analysis of S6D2 clusters confirmed the existence of the three major pancreatic endocrine cell populations (β cells, α-like cells and δ-like cells) and their proportions, which altogether accounted for 80%. more...
#> 65                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   Human pluripotent stem cell-derived islets (hPSC-islets) are a promising cell resource for diabetes treatment. Here, we demonstrate that transplantation of human pluripotent stem cell-derived islets into diabetic nonhuman primates effectively restored endogenous insulin secretion and improved glycemic control. Single-cell RNA sequencing analysis of S6D2 clusters confirmed the existence of the three major pancreatic endocrine cell populations (β cells, α-like cells and δ-like cells) and their proportions, which altogether accounted for 80%. more...
#> 66                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                We profiled three prominent ATM subtypes from human visceral omental adipose tissue in obesity by RNA-seq. In the related manuscript, we evaluated differences in their signatures and their relationship to type 2 diabetes:  Visceral (VAT) and subcutaneous (SAT) adipose tissue samples were collected from diabetic and non-diabetic obese subjects to evaluate cellular content and gene expression. VAT CD206+CD11c− ATMs were increased in diabetic subjects, scavenger receptor-rich with low intracellular lipids, secreted proinflammatory cytokines, and diverged significantly from two CD11c+ ATM subtypes, which were lipid-laden, lipid antigen presenting, and overlapped with monocyte signatures. more...
#> 67                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           Up until now, no study has looked specifically at epigenomic landscapes throughout twin samples, discordant for Anorexia nervosa (AN). Our goal was to find evidence to confirm the hypothesis that epigenetic variations play a key role in the aetiology of AN. In this study, we quantified genome-wide patterns of DNA methylation using the Infinium Human DNA Methylation EPIC BeadChip array (850K) in DNA samples isolated from whole blood collected from a group of 7 monozygotic twin pairs discordant for AN. more...
#> 68                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               Genome wide DNA methylation profiling of blood samples collected from patients after diagnosis with hepatocellular carcinoma (HCC) (cases) vs. blood samples collected from healthy individuals without family history of cancer (controls). The Illumina Infinium 450K Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 450,000 CpGs in human samples corresponding to cases (post-diagnostic HCC) and controls. more...
#> 69                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Genome wide DNA methylation profiling of blood samples collected from patients prior to diagnosis with hepatocellular carcinoma (HCC) vs. blood samples collected from healthy individuals without family history of cancer. The Illumina Infinium 450K Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 450,000 CpGs in human samples corresponding to cases (pre-diagnostic HCC) and controls. more...
#> 70                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 β cell proliferation rates decline with age and adult β cells have limited self-duplicating activity for regeneration, which predisposes to diabetes. Here we show that, among MYC family members, Mycl was expressed preferentially in proliferating immature endocrine cells. Genetic ablation of Mycl caused a modest reduction in cell proliferation of pancreatic endocrine cells in neonatal mice. By contrast, systemic expression of Mycl in mice stimulated proliferation in pancreatic islet cells and resulted in expansion of pancreatic islets without forming tumors in other organs. more...
#> 71                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Fibrous membrane (FM), the hallmark for proliferative diabetic retinopathy (PDR) and proliferative vitreoretinopathy (PVR), can cause hemorrhages and retinal detachment, which may lead to blindness if not properly treated. However, little is known about the pathophysiology of FM. In this study, we successfully employed single-cell RNA sequencing on the small-sized vitreous FMs, and generated a comprehensive cell atlas of FMs derived from PVR and PDR. more...
#> 72                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Purpose: Short chain fatty acids (SCFAs) produced by the gut microbiota have dual beneficial anti-inflammatory and anti-dysbiotic effects associated with the prevention of type 1 diabetes (T1D) in mice. We have conducted a single-arm trial of a dietary supplement (HAMSAB), to determine the effects of increasing SCFA delivery  in adults with long-standing T1D. Particularly, we examined blood transcriptome in these patients using RNA-seq. more...
#> 73                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             Purpose: The goal of this study is to conduct and compare NGS-derived transcriptome profiling (RNA-seq) of progenitor lines derived from 3 HNF1A-WT and 3 HNF1A-CRISPR (with p291fsinsC mutation) human induced pluripotent stem cell lines. Methods: mRNA profiles of WT/CRISPR pancreatic progenitor cells obtained after in-vitro differentiation for 14 days were generated by deep sequencing using Illumina HiSeq 2000 sequencer. more...
#> 74                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Several studies have suggested a relationship between SARS-CoV-2 infection and diabetes. This study examined the consequences of infection of human pancreatic islets with SARS-CoV-2 virus. This GEO submission contains the raw and processed data from single-cell RNA sequencing (scRNAseq) experiments evaluating the tropism of SARS-CoV-2 in pancreatic islets and transcriptional changes induced by infection of these cells. more...
#> 75                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Exosomal RNAs in cord blood may allow intercellular communication between  maternal and fetus. We aimed to establish exosomal RNA expression profiles in cord blood exosomes from gestational diabetes mellitus (GDM) patients with macrosomia.We used microarray technology to establish the differential mRNA, lncRNA and circRNA expression profiles in cord blood exosomes from GDM patients with macrosomia compared with normal controls. more...
#> 76                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       To compare the circRNA expression profile of diabetic retinopathy with that of diabetes mellitus and controls, peripheral blood mononuclear cell samples were obtained and extracted from healthy controls and diabetes mellitus patients (with or without diabetic retinopathy). CircRNA Capital Bio Technology Human CircRNA Array v2 was performed to detect circRNA expression profiles. To further check differentiate circRNA, qRT_PCR assay was performed to detect the level of 5 candidates.
#> 77                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         Purpose:Metabolic syndrome (MetS) is associated with a group of conditions including diabetes, obesity, insulin resistance etc. The goal of our study is to identify the differentially regulated genes under metabolic syndromes induced by TNF-α. Methods:A Homosapines Reference based Transcriptome sequencing is performed to understand the genes that are diffrerentially regulated under metabolic synromes with TNF-α as upstream. more...
#> 78                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           Type 1 diabetes (T1D) results from autoimmune destruction of β-cells in the pancreas. Protein tyrosine phosphatases (PTPs) are candidate genes for T1D and play a key role in autoimmune disease development and β-cell function. Here, we assessed the global protein and individual PTP profile in the pancreas from diabetic NOD mice treated with anti-CD3 monoclonal antibody and IL-1 receptor antagonist (IL-1RA). more...
#> 79                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             Ex-vivo pharmacological modulation enhances the immunoregulatory and trafficking properties of HSCs which mitigated autoimmune diabetes and other autoimmune disorders. We used GeneChip microarrays to compare the whole transcriptomes of vehicle (DMSO) and dmPGE2 (10uM) + Dexamenthasone (uM) modulated human CD34+ HSPCs.
#> 80                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   Aims/hypothesis. Ectopic calcification is a typical feature of diabetic vascular disease and resembles an accelerated aging phenotype. We previously found an excess of myeloid calcifying cells (MCCs) in diabetic patients. We herein examined molecular and cellular pathways linking atherosclerotic calcification with calcification by myeloid cells in the diabetic milieu. Methods. We first examined the associations among coronary calcification, MCC levels, and mononuclear cell gene expression in a cross-sectional study of 87 type 2 diabetic patients undergoing elective coronary angiography. more...
#> 81                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           Objective: To explore the mechanism of Jiangtang Tiaozhi Recipe in the treatment of obese T2DM patients with dyslipidemia based on transcriptomics.  Methods: We chose 6 patients with obese type 2 diabetes mellitus and dyslipidemia (syndrome of excess of gastrointestinal heat) who were treated by JTTZR for 24 weeks, while 6 cases included in the healthy control group. We selected 6 cases in each group (disease group before treatment, disease group after treatment and healthy control group) to start the research of lncRNA microarray. more...
#> 82                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             White adipose tissue (WAT), once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic, heterogenous, and involved in a wide array of biological processes including energy homeostasis, glucose and lipid handling, blood pressure control, and host defense.  High fat feeding and other metabolic stressors cause dramatic changes in adipose morphology, physiology, and cellular composition, and alterations in adiposity are associated with insulin resistance, dyslipidemia, and Type 2 diabetes (T2D). more...
#> 83                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          We report single-cell RNA-seq (Drop-seq) data from the stromal vascular fraction (SVF) of human subcutaneous adipose tissue (SAT).
#> 84                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Development of insulin resistance is a key pathogenic component underlying metabolic syndrome and Type 2 diabetes (T2DM). Despite its importance, the molecular mechanisms underlying insulin resistance are poorly understood. Genome-wide association studies for T2DM and other metabolic traits have led to the identification of many candidate SNPs, but the majority of these SNPs are noncoding and determination of associated causal genes and/or specific tissue sites of action have been difficult. more...
#> 85                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Background Changes in innate and adaptive immunity occurring in/around pancreatic islets had been observed in peripheral blood mononuclear cells (PBMC) of Caucasian T1D patients by some, but not all researchers. The aim of our study was to investigate whether gene expression patterns of PBMC of the highly admixed Brazilian population could add knowledge about T1D pathogenic mechanisms.  METHODS: We assessed global gene expression in PBMC from two groups matched for age, sex and BMI: 20 patients with recent-onset T1D (≤ 6 months from diagnosis, in a time when the autoimmune process is still highly active), testing positive for one or more islet autoantibodies and 20 islet autoantibody-negative healthy controls. more...
#> 86                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Changes in innate and adaptive immunity occurring in and around pancreatic islets can also be observed in peripheral  blood mononuclear cells (PBMC) of T1D patients  in Caucasians. The aim of our study was to investigate whether gene expression patterns of PBMC could complement islet autoantibodies for T1D pathogenic mechanisms in the higlty admixed Brazilian population. Methods: We assessed global gene expression in PBMC from  two groups mached for age, sex and BMI: The T1D group with 20 patients with recent-onset T1D (≤ 6 months from diagnosis, in a time  when the autoimmune process is still highly active), testing positive for one or more  islet autoantibodies and 20 islet autoantibody-negative healthy controls (Control group). more...
#> 87                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 This SuperSeries is composed of the SubSeries listed below.
#> 88                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GDM is a multi-system disorder that is primarily characterised by new-onset hypertension accompanied by proteinuria during gestation. This disease is one of the leading causes of maternal and perinatal morbidity and mortality. In this work, placental samples were collected from GDM and control patients. RNA-seq was performed to identify differences in gene expression. Significantly differentially expressed genes between the GDM and control samples included 64 up-regulated and 296 down-regulated genes. more...
#> 89                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic mRNA and potential regulatory functions of m6A have been shown by mapping the RNA m6A modification landscape. M6A modification in active gene regulation manifests itself as altered methylation profiles. However, the profiling of m6A modification and its potential role in gestational diabetes mellitus (GDM) has not yet been studied. more...
#> 90                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               Intervertebral disc degeneration (IDD) is majorly resulted from disordered extracellular matrix (ECM) metabolism, including decreased anabolism and increased catabolism activities in the nucleus pulposus (NP) cells of discs. Pro-inflammatory cytokines such as interleukin-1β (IL-1β) are considered to be potent mediators of ECM loss. We reported previously that hemeoxygenase-1 (HO-1) inducer cobalt protoporphyrin IX (CoPP) could attenuate the ECM breakdown which induced by IL-1β, however, the underlying mechanism remains elusive. more...
#> 91                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Background. Diabetes mellitus (DM) increases tuberculosis (TB) severity. We previously reported baseline blood microarray data in a South Indian pulmonary TB cohort with or without DM, finding no qualitative or quantitative differences in immune pathway gene expression. To extend those observations, we compared baseline and longitudinal blood gene expression in TB patients from South India and Brazil. more...
#> 92                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 Introduction.  Epigenetic modifications have been implicated to mediate several complications of diabetes mellitus (DM), especially nephropathy and retinopathy. Our aims were to ascertain if epigenetic alterations in whole blood discriminate among DM patients with normal, delayed and rapid gastric emptying (GE). Methods.  Using ChIP-seq (Chromatin immunoprecipitation combined with next generation sequencing) assays, we compared the genome-wide enrichment of three histone modifications (ie, H3K4me3, H3K9ac and H3K27ac) in buffy coats from 20 DM patients with normal (n=6), delayed (n=8), or rapid (n=6) GE. more...
#> 93                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Type 2 diabetes (T2D) is associated with cardiovascular-renal complications and premature death. Although most patients with T2D are obese, not all obese individuals develop T2D. Thus, an understanding of the mechanistic relationships between obesity and T2D is crucial. In this study, using subcutaneous (SAT) and visceral adipose tissues (VAT) from obese individuals with or without T2D collected during metabolic surgery, integration of the transcriptomes and methylomes of VAT and SAT with publicly available tissue-specific regulatory networks, we discovered the close relation between T2D and inflammatory response in both SAT and VAT in obese individuals, although less differences were observed respectively in transcriptome or methylome. more...
#> 94                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 This SuperSeries is composed of the SubSeries listed below.
#> 95                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Purpose:  The goals of this study is to compare and profile the smallRNA transcriptome of the placenta in preeclamptic and normal patients using RNA sequencing. Methods: Placental and Placental vesicles (STB-EVs)  smallRNA profiles of normal and preeclamptic patients were generated by deep sequencing using Illumina HISEQ. FASTq.gz files were compressed with OASIS compressor and alignment was done with OASIS 2.0 ( by trimmimng with trimmomatic, aligning using default OASIS 2.0 aligning papameters). more...
#> 96                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             Purpose:  The goals of this study is to compare and profile the transcriptome of the placenta in preeclamptic and normal patients using RNA sequencing. Methods: Placental and Placental vesicles (STB-EVs)  mRNA profiles of normal and preeclamptic patients were generated by deep sequencing using Illumina HISEQ. The sequence reads that passed quality filters were analyzed at the gene level HISAT2 followed by featureCounts. more...
#> 97                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Enteroviruses, particularly the group B Coxsackieviruses have been associated with the development of type 1 diabetes. Several CVB serotypes can establish chronic infection in human cells in vivo and in vitro. However, the mechanisms of leading to enterovirus persistency and, possibly, bell-cell autoimmunity are not fully understood. We established a carrier-state persistent infection model in human pancreatic ductal-like cell line PANC-1 using two distinct CVB1 strains and profiled infection-induced changes in cellular transcriptome. more...
#> 98                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Human islet antigen reactive CD4+ memory T cells (IAR T cells) play a key role in the pathogenesis of autoimmune type 1 diabetes (T1D). Using single cell RNA-sequencing (scRNA-seq) to identify T cell receptors (TCRs) in IAR T cells, we have identified a class of TCRs that share TCR alpha chains between individuals (“public”).
#> 99                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 Fungiform papillae (FP) are visible protrusions on the anterior tongue surface that contain taste buds, their nerves, and capillaries, epithelial cells, stromal cells, and immune-surveilling cells. As FP are easily biopsied in a minimally invasive procedure and have been shown to regrow, we compared three different mechanical methods of FP protein extraction and found that mechanical disruption of FP under liquid nitrogen or bead beating were more efficient than mincing in terms of yield and proteomic profile. more...
#> 100                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Fetal progenitor endothelial cells (endothelial colony forming cells; ECFC) are recruited for repair, vascular growth and angiogenesis and their high abundance perinatally suggests a function in postnatal vasculogenesis and angiogenesis. In this study we profiled ECFCs from pregnancies of control, overweight and diabetic mothers to study if adverse pregnancies are associated with epigenetic variation in ECFCs.
#> 101                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   The establishment and function of the human placenta is dependent on specialized cells called trophoblasts. Unfortunately, little is known about the cellular and molecular processes controlling human trophoblast stem cell maintenance and differentiation into mature trophoblast sub-populations/cell states. To address this, we here report transcriptomic data from n=7 first trimester human placental tissues, n=3 regenerative human trophoblast stem cell (hTSC) derived trophoblast organoids, and n=3 EVT-differentiated hTSC derived organoid cultures at single-cell resolution. more...
#> 102                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Physical training improves insulin sensitivity and can prevent type 2 diabetes. However, approximately 20% of individuals lack a beneficial outcome in glycemic control. TGF-β, identified as a possible upstream regulator involved in this low response is also a potent regulator of microRNAs (miRs). Aim of this study was to elucidate the potential impact of TGF-β-driven miRNAs on individual exercise response. more...
#> 103                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Physical training improves insulin sensitivity and can prevent type 2 diabetes. However, approximately 20% of individuals lack a beneficial outcome in glycemic control. TGF-β, identified as a possible upstream regulator involved in this low response is also a potent regulator of microRNAs (miRs). Aim of this study was to elucidate the potential impact of TGF-β-driven miRNAs on individual exercise response. more...
#> 104                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Arterial media calcification caused by diabetes is an important cause of vascular calcification. Dipeptidyl peptidase-4 (DPP4) is associated with diabetic arterial media calcification. At the same time, long non-coding RNA(lncRNA) is closely related to the evolution of a variety of cardiovascular diseases, but the involvement of lncRNA in vascular calcification induced by DPP4 has not been reported in details. more...
#> 105                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             MODY8 (maturity-onset diabetes of the young, type 8) is a dominantly inherited monogenic form of diabetes associated with frameshift mutations in the carboxyl ester lipase (CEL) gene expressed by pancreatic acinar cells. Patients carrying the mutation develop childhood-onset exocrine pancreas dysfunction followed by the manifestation of diabetes during adulthood. However, it is unclear how CEL mutations cause diabetes. more...
#> 106                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Currently, no oral medications are available for individuals suffering from type 1 diabetes (T1D). Our randomized placebo-controlled phase 2 trial recently revealed that oral verapamil has short- term beneficial effects in subjects with new-onset type 1 diabetes (T1D) 1. However, what exact biological changes verapamil elicits in humans with T1D, how long they may last, and how to best monitor any associated therapeutic success has remained elusive. more...
#> 107                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           About 20% of youth are obese with higher risk for cardiovascular disease and type 2 diabetes (T2D). We have recently reported that in obese adolescents altered pattern of fat distribution is associated with insulin resistance and T2D. In particular, the high ratio of visceral AT depot (VAT) to abdominal subcutaneous AT depot (SAT) (high VAT/(VAT+SAT)) was associated with a metabolically unhealthy phenotype with high risk for insulin resistance and T2D. more...
#> 108                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                This SuperSeries is composed of the SubSeries listed below.
#> 109                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 We conducted prospective clinical studies to validate the importance of CD4+ T cells in 13 diseases from the following ICD-10-CM chapters: Neoplasms (breast cancer, chronic lymphocytic leukemia); endocrine, nutritional and metabolic diseases (type I diabetes, obesity); diseases of the circulatory system (atherosclerosis); diseases of the respiratory system (acute tonsillitis, influenza, seasonal allergic rhinitis, asthma); diseases of the digestive system (Crohn’s disease [CD], ulcerative colitis [UC]); and diseases of the skin and subcutaneous tissue (atopic eczema, psoriatic diseases). more...
#> 110                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Salivary exsomal miRNAs may play important role in the pathogenesis of chronic inflammatory disease, such as periodontitis. There are many studies which suggested the connection between periodontitis and systemic disease, however, the role of specific miRNA as a intersection of periontitis and diabetes are not elucidated. We suggested miR-25-3p as possible common mediator in the pathogenesis of periodontitis and diabetes.
#> 111                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Diabetic retinopathy (DR) is a common microvascular complication that may cause severe visual impairment and blindness in patients with type 2 diabetes mellitus (T2DM). Early detection of DR will provide opportunities for more treatment options and better control of disease progression. Effective biomarkers, which are not currently available, may improve clinical outcomes through precise diagnosis and prognosis. more...
#> 112                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                This SuperSeries is composed of the SubSeries listed below.
#> 113                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   First-degree relatives (FDRs) of type 2 diabetics (T2D) feature dysfunction of subcutaneous adipose tissue (SAT) long before T2D onset. miRNAs have a role in adipocyte precursor cells (APC) differentiation and in adipocyte identity. Thus, impaired miRNA expression may contribute to SAT dysfunction in FDRs. In the present work, we have explored changes of miRNA expression associated with T2D family history which may affect gene expression in SAT APCs from FDRs. more...
#> 114                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   First-degree relatives (FDRs) of type 2 diabetics (T2D) feature dysfunction of subcutaneous adipose tissue (SAT) long before T2D onset. miRNAs have a role in adipocyte precursor cells (APC) differentiation and in adipocyte identity. Thus, impaired miRNA expression may contribute to SAT dysfunction in FDRs. In the present work, we have explored changes of miRNA expression associated with T2D family history which may affect gene expression in SAT APCs from FDRs. more...
#> 115                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Using next generation RNA sequencing (RNA-seq), this study evaluated the whole transcriptome of subcutaneous (SC) and omental (OM) adipose tissues from patients with gestational diabetes (GD) and healthy matching controls that were collected during cesarean delivery (C-section). Results show a strong separation of the transcriptomic profiles based on anatomical location and reveal specific RNA expression patterns unique to GD patients
#> 116                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                This SuperSeries is composed of the SubSeries listed below.
#> 117                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Most obese and insulin resistant individuals do not develop diabetes. This is the result of the capacity of β-cells to adapt and produce enough insulin to cover the needs of the organism. The underlying mechanism of β-cell adaptation in obesity, however, remains unclear. Previous studies have suggested a role for STAT3 in mediating β-cell development and human glucose homeostasis, but little is known about its role in β-cells in obesity. more...
#> 118                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               Type 2 diabetes is associated with defective insulin secretion and reduced β-cell mass. Available treatments provide a temporary reprieve, but secondary failure rates are high, making insulin supplementation necessary. Reversibility of b-cell failure is a key translational question. Here, we reverse-engineered and interrogated pancreatic islet-specific regulatory networks to discover T2D-specific subpopulations characterized by metabolic-inflexibility and endocrine-progenitor/stem cell features. more...
#> 119                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               Type 2 diabetes is associated with defective insulin secretion and reduced β-cell mass. Available treatments provide a temporary reprieve, but secondary failure rates are high, making insulin supplementation necessary. Reversibility of b-cell failure is a key translational question. Here, we reverse-engineered and interrogated pancreatic islet-specific regulatory networks to discover T2D-specific subpopulations characterized by metabolic-inflexibility and endocrine-progenitor/stem cell features. more...
#> 120                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               Type 2 diabetes is associated with defective insulin secretion and reduced β-cell mass. Available treatments provide a temporary reprieve, but secondary failure rates are high, making insulin supplementation necessary. Reversibility of b-cell failure is a key translational question. Here, we reverse-engineered and interrogated pancreatic islet-specific regulatory networks to discover T2D-specific subpopulations characterized by metabolic-inflexibility and endocrine-progenitor/stem cell features. more...
#> 121                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                The expression of SEMA3E isoforms changes in mouse circulation with type 1 diabetes. The alterations in the transcriptional profiles of human aortic endothelial cells (HAECs) in response to PCS1 (Processing consensus sequences)-cleaved SEMA3E and PCS1-uncleaved SEMA3E were examined.
#> 122                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Diabetic foot ulcers (DFUs) are a devastating complication of diabetes. In order to identify systemic and local factors associated with DFU healing, we examined the cellular landscape of DFUs by single-cell RNA-seq analysis of foot and forearm skin specimens, as well as PBMC samples, from 10 non-diabetic subjects, and 17 diabetic patients, 11 with, and 6 without DFU. Our analysis shows enrichment of a unique inflammatory fibroblast population in DFU patients with healing wounds. more...
#> 123                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             Background: Proliferative diabetic retinopathy (PDR) is hallmarked by the formation of retinal neovascularization (RNV) membranes, which can lead to a tractional retinal detachment, the primary reason for severe vision loss in end-stage disease. The aim of this study was to characterize the molecular and cellular features of RNV in order to unravel potential novel drug treatments for PDR.  Methods: A total of 42 patients undergoing vitrectomy for PDR, macular pucker or macular hole (control patients) were included in this study. more...
#> 124                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Preclinical models of type 1 diabetes mellitus exhibit marked declines in skeletal muscle health including significant impairments in muscle repair. The present study investigated, for the first time, whether muscle repair was altered in young adults with uncomplicated type 1 diabetes (T1D) following damaging exercise.In this cohort study, eighteen physically-active young adults (M=22.1, SEM=0.9 years) with T1D (n, male/female=4/5; MHbA1c= 58, SEMHbA1c=5.9 mmol/mol) and without T1D (n, male/female=4/5) performed 300 unilateral eccentric contractions (90°s-1) of the knee extensors. more...
#> 125                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Diabetic foot ulcers (DFUs) are a devastating complication of diabetes. To better understand the molecular mechanisms and cell types implicated in DFU healing, we used NanoString’s GeoMx Digital Spatial profiling platform on DFU tissue sections and compared gene expression of areas within the same ulcer as well as between patients who in 12 weeks following surgery healed their DFU (Healers, N=2) vs those who did not (Non-Healers, N=2).
#> 126                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                This SuperSeries is composed of the SubSeries listed below.
#> 127                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Long non-coding RNAs (lncRNAs) are widely involved in gene transcription regulation and which act as epigenetic modifiers. To determine whether lncRNAs are involved in ischemic stroke (IS), we analyzed the expression profile of lncRNAs and mRNAs in IS. RNA sequencing was performed on the blood of three pairs of IS patients and heathy controls. Differential expression analysis was used to identify differentially expressed lncRNAs (DElncRNAs) and mRNAs (DEmRNAs). more...
#> 128                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       Cardiovascular disease (CVD) is the leading cause of mortality in diabetes mellitus (DM). However, the molecular factors that cause this disproportiona increase in CVD in the DM/chronic kidney disease (CKD) population are still unknown.Human endothelial cells treated with high glucose to mimic DM and with the uremic toxin indoxyl sulfate (IS) to mimic the endothelial injury associated with CKD. Differentially expressed lncRNAs in these conditions were analyzed by RNA sequencing.Lnc-SLC15A1-1 expression was significantly increased upon IS treatment versus high glucose alone.
#> 129                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          The pathogenesis of non-alcoholic fatty liver disease is not fully understood. Transcriptomic analysis of a large cohort of 318 patients provides evidence of gene perturbations related to inflammation, complement and coagulation pathways, and tissue remodeling in distinct states of NAFLD.
#> 130                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 N6-methyladnine, which is the most abundant post-transcriptional RNA modification in eukaryotic mRNA, has been proved to be essential in various biological processes and related to numerous diseases. Transcriptome-wide m6A profiling by next generation sequencing is widely used to explore the distributions as well as quantity of m6A modifications. As traditional m6A-seq demands large amount of starting RNA which limited its application to clinical samples, we present a strategy of low input multi-barcode m6A-seq (SLIM-m6A-seq) to realize simplified m6A profiling of mixed clinical samples. more...
#> 131                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Stem cell derived beta-like cells (sBC) carry the promise of providing an abundant source of insulin-producing cells for use in cell replacement therapy for patients with diabetes, potentially allowing widespread implementation of a practical cure. To achieve their clinical promise, sBC need to function comparably to mature adult beta cells, but as yet they display varying degrees of maturity. Indeed, detailed knowledge of the events resulting in human beta cell maturation remains obscure. more...
#> 132                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        The goal of this study is to compare RNA-seq of wild-type fibroblasts and patient fibroblasts bearing the m.3243A>G mutatioin. When comparing patient fibroblasts to wild-type ones and using a significance level of false discovery rate (FDR) < 0.05, we identified 3394 transcripts of which 1849 were upregulated and 1545 were downregulated.
#> 133                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         Heterozygous human INS gene mutations are known to promote ER stress, leading to β-cell dysfunction and neonatal diabetes. Recent literature challenged the long-standing notion that neonatal diabetes occurs due to ER stress-induced β-cell apoptosis. Importantly, mechanisms of β-cell failure during the disease progression and why the other wild-type (WT) INS allele is unable to function still remain unclear. more...
#> 134                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     The objective of this study is to investigate alveolar bone gene expression in health and diabetes through RNA-sequencing and bioinformatics analysis.
#> 135                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    The mechanisms of obesity and type 2 diabetes (T2D)-associated impaired fracture healing are poorly studied. In a murine model of T2D reflecting both hyperinsulinemia induced by high fat diet (HFD) and insulinopenia induced by treatment with streptozotocin (STZ), we examined bone healing in a tibia cortical bone defect. A delayed bone healing was observed during hyperinsulinemia as newly formed bone was reduced by – 28.4±7.7% and was associated with accumulation of marrow adipocytes at the defect site +124.06±38.71%, and increased density of SCA1+ (+74.99± 29.19%) but not Runx2+osteoprogenitor cells. more...
#> 136                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              BACKGROUND AND AIMS: It is proposed that impaired expansion of subcutaneous adipose tissue (SAT), caused in part by an increase in adipose tissue fibrosis, redirects fatty acids to the liver and other organs, leading to ectopic lipid accumulation and insulin resistance. We therefore evaluated whether a decrease in SAT expandability, assessed by measuring SAT lipogenesis (triglyceride production), and an increase in SAT fibrogenesis (collagen production) are associated with nonalcoholic fatty liver disease (NAFLD) and insulin resistance in people with obesity. more...
#> 137                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Retinal neovascularization is a severe complication of proliferative diabetic retinopathy. We have previously identified that miRNAs is directly involved in the development of retinal neovascularization. Here, we explored the role of miRNAs and its underlying mechanism in modulating angiogenesis.
#> 138                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Background: A previous Phase I study showed that the infusion of autologous Treg cells expanded ex-vivo into recent onset Type 1 Diabetes (T1D) patients had an excellent safety profile, however, the majority of the infused Tregs could no longer be detected in the peripheral blood three months post-infusion (NCT01210664-Treg-T1D Trial). Interleukin-2 (IL-2) is a well-characterized cytokine that has been shown to enhance human Treg cell survival and expansion at low doses in vivo. more...
#> 139                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Developmental alteration in brain wiring that would make it more susceptible to later pathological processes has been suggested as a basis for the occurrence of neurodegenerative diseases, but mechanisms have remained elusive. A recent series of magnetic resonance imaging studies have demonstrated that, in Wolfram syndrome, neurodegenerative processes appear during childhood and adolescence on top of a clinically silent global defect in brain development. more...
#> 140                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                The aim of this study is to investigate the impact of the metabolic status on the transcriptome of isolated preadipocytes and in vitro differentiated adipocytes. We identified 38654 transcripts in pancreatic fat cells. We report that preadipocyte differentiation increased the abundance of mRNA levels of proteins related to adipogenesis and lipid metabolism. These changes in the transcriptome were absent or less pronounced in fat cells obtained from patients with prediabetes and type 2 diabetes. more...
#> 141                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Type 2 diabetes is a complex, systemic disease affected by both genetic and environmental factors. Previous research has identified genetic variants associated with type 2 diabetes risk, however gene regulatory changes underlying progression to disease are still largely unknown. We investigated RNA expression changes that occur during diabetes progression using a two-stage approach. In our discovery stage, we compared changes in gene expression using two longitudinally collected blood samples from subjects who transitioned to type 2 diabetes between the time points against those who did not with a novel analytical network approach. more...
#> 142                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             Free fatty acids (FFAs) are often stored in lipid droplet (LD) depots for eventual metabolic and/or synthetic use in many cell types, such a muscle, liver, and fat. In pancreatic islets, overt LD accumulation was detected in humans but not mice. LD buildup in islets was principally observed after roughly 11 years of age, increasing throughout adulthood under physiologic conditions, and also enriched in type 2 diabetes. more...
#> 143                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Dysregulation of macrophage populations at the wound site is responsible for the non-healing state of chronic wounds. The molecular mechanisms underlying macrophage dysfunction and its control in diabetes are largely unexplored on an epigenetic level. Here, we report that acetyl histone-H3 (Lys27), an epigenetic mark regulating the macrophage transcriptome, is lost in the hostile tissue microenvironment in diabetes. more...
#> 144                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Permutational analysis of immune landscape reveals advanced immune aging in people with Down syndrome and in people with type 1 diabetes.
#> 145                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         Islet-enriched transcription factors (TFs) exert broad control over cellular processes in pancreatic α and β cells and changes in their expression are associated with developmental state and diabetes. However, the implications of heterogeneity in TF expression across islet cell populations are not well understood. To define this TF heterogeneity and its consequences for cellular function, we profiled >40,000 cells from normal human islets by scRNA-seq and stratified α and β cells based on combinatorial TF expression. more...
#> 146                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Purpose: Excess oxidative stress (OS) impairs endothelial function and plays an important role in vascular diseases, diabetes, and neuronal disorders. Several consequences of OS including cell recovery and apoptosis have been described previously. In this study, we report systems model of the temporal dynamics of the oxidative stress response in Human Umbilical Vein Endothelial Cells (HUVECs) and characterize HMOX1 as a master regulator in orchestrating the response to oxidative stress. more...
#> 147                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      ATAC-seq (assay for transposase-accessible chromatin followed by sequencing) is widely used to decode chromatin accessibility. Here we performed high-sensitive ATAC-seq in 9 human liver samples from normal and T2D donors, and identified a set of differentially accessible regions (DARs). DARs were overlapped with publicly available CREs databases and integrated with multi-omics data to identify candidates for further experimental validations. more...
#> 148                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Single nuclei sequencing of grafts developed 14 weeks post transplantation of human embryonic stem cell derived pancreatic progenitors alone (PP) or with rat adipose derived microvessels (PPMV) into the subcutaneous pocket of diabetic (STZ-induced) Scid-beige mice.
#> 149                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                This SuperSeries is composed of the SubSeries listed below.
#> 150                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Persons living with HIV (PLWH) are at increased risk of tuberculosis (TB). HIV-associated TB is mainly the result of recent infection with Mycobacterium tuberculosis (Mtb) followed by rapid progression to disease. Alveolar macrophages (AM) are the first cells of the innate immune system that engage Mtb, but how HIV and antiretroviral therapy (ART) impact on the anti-mycobacterial response of AM is not known. more...
#> 151                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Persons living with HIV (PLWH) are at increased risk of tuberculosis (TB). HIV-associated TB is mainly the result of recent infection with Mycobacterium tuberculosis (Mtb) followed by rapid progression to disease. Alveolar macrophages (AM) are the first cells of the innate immune system that engage Mtb, but how HIV and antiretroviral therapy (ART) impact on the anti-mycobacterial response of AM is not known. more...
#> 152                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Circular RNA can regulate blood glucose levels by targeting mRNA expression, but the role of circRNA in GDM is still unknown. Therefore, a joint microarray analysis of circRNAs and their targeting mRNAs using the peripheral blood of GDM patients and healthy pregnant women was carried out for the first time. In our study, high-throughput microarray sequencing technique was used to analyze the expression profile of circRNA and transcripts mRNA in the peripheral blood of GDM patients, in order to comprehensively evaluate the role of circRNAs targets and their parents genes in the signal pathways related to the pathogenesis of GDM. more...
#> 153                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    To improve the power of mediation in high-throughput studies, here we introduce High-throughput mediation analysis (Hitman), which accounts for direction of mediation and applies empirical Bayesian linear modeling. We apply Hitman in a retrospective, exploratory analysis of the SLIMM-T2D clinical trial in which participants with type 2 diabetes were randomized to Roux-en-Y gastric bypass (RYGB) or nonsurgical diabetes/weight management, and fasting plasma proteome and metabolome were assayed up to 3 years. more...
#> 154                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         Congenital generalized lipodystrophy (CGL) is an autosomal recessive disorder characterized by defective adipose tissue, extreme insulin resistance, and early onset of diabetes. There are four types of congenital generalized lipodystrophy based on the causative genetic alterations. The symptoms and the degrees of disease progression are varied among all affected individuals, which might be due to unknown genetic modifiers. more...
#> 155                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                This SuperSeries is composed of the SubSeries listed below.
#> 156                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Circadian rhythms are generated by an auto-regulatory feedback loop composed of transcriptional activators and repressors. Disruption of circadian rhythms contributes to Type 2 diabetes (T2D) pathogenesis. We elucidated whether altered circadian rhythmicity of clock genes is associated with metabolic dysfunction in T2D. Transcriptional cycling of core clock genes BMAL1, CLOCK, and PER3 was altered in skeletal muscle from individuals with T2D and this was coupled with reduced number and amplitude of cycling genes and disturbed circadian oxygen consumption. more...
#> 157                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Circadian rhythms are generated by an auto-regulatory feedback loop composed of transcriptional activators and repressors. Disruption of circadian rhythms contributes to Type 2 diabetes (T2D) pathogenesis. We elucidated whether altered circadian rhythmicity of clock genes is associated with metabolic dysfunction in T2D. Transcriptional cycling of core clock genes BMAL1, CLOCK, and PER3 was altered in skeletal muscle from individuals with T2D and this was coupled with reduced number and amplitude of cycling genes and disturbed circadian oxygen consumption. more...
#> 158                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       we apply miRNA sequencing from blood samples of 10 DMED patients and 10 DM controls to study the mechanism of miRNAs action on DMED.
#> 159                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         Genome Wides Association Studies (GWAS) have identified tens of thousands of associations between human genetic variation and common disease. The majority of causative variants lie in regulatory elements that are located some distance from their target genes. High resolution chromosome conformation capture (3C) has proven useful for identifying enhancer-promoter interaction. We employed targeted Capture-C at loci with GWAS for severe COVID-19, Type-1 Diabetes (T1D), Ankylosing spondylitis (AS) and red blood cell traits (RBC)
#> 160                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   Severe angiopathy is a major driver for diabetes associated secondary complications. Knowledge on underlying mechanisms essential for advanced therapies to attenuate these pathologies is limited. Injection of ABCB5+ stromal precursors (SPs) at the edge of non-healing diabetic wounds in a murine db/db model, closely mirroring human type II diabetes, profoundly accelerates wound closure. Strikingly, enhanced angiogenesis was substantially enforced by the release of the ribonuclease angiogenin from ABCB5+ SPs. more...
#> 161                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   Hepatic lipid accumulation is a hallmark of type 2 diabetes (T2D) and associated with hyperinsulinemia, insulin resistance, and hyperphagia. Hepatic synthesis of GABA, catalyzed by GABA-transaminase (GABA-T), is upregulated in obese mice. To assess the role of hepatic GABA production in obesity-induced metabolic and energy dysregulation, we treated mice with two pharmacologic GABA-T inhibitors and also knocked down hepatic GABA-T expression using an antisense oligonucleotide. more...
#> 162                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   Dysregulation of glucagon secretion in type 1 diabetes (T1D) involves hypersecretion during postprandial states, but insufficient secretion during hypoglycemia. The sympathetic nervous system regulates glucagon secretion. To investigate islet sympathetic innervation in T1D, sympathetic tyrosine hydroxylase (TH) axons were analyzed in control non-diabetic organ donors, non-diabetic islet autoantibody-positive individuals (AAb), and age-matched persons with T1D. more...
#> 163                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  We employed a microarray as a discovery platform to identify the differential gene expressions between hND islets and hT2DM islets. 4805 genes with differential expression (fold change >2) were manifested in hT2DM islets. Inflammatory response and immune response were the mostly upregulated biological processes distinguished betwee hND islets and T2DM islets. Results provided insight into the molecular mechanisms in T2DM.
#> 164                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               Epidemiological evidence has identified an association between breast cancer (BC) and systemic dysregulation of glucose metabolism. However, how BC influences glucose homeostasis remains unknown. Here we show that BC-derived extracellular vesicles (EVs) suppress pancreatic endocrine secretion to systemically reset glucose homeostasis. In pancreatic β-cells, miR-122 delivered in BC-derived EVs targets PKM to suppress glycolysis and ATP-dependent insulin exocytosis. more...
#> 165                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   Heterozygous mutations in HNF1B in humans result in a multi-system disorder, including pancreatic hypoplasia and diabetes mellitus. The underlying mechanisms that contribute to disease pathogenesis remain largely unknown, partially accounted by the fact that mouse models with heterozygous deletions in Hnf1b do not develop diabetes, in contrast to the phenotypes observed in MODY patients. Here we used a well-controlled human induced pluripotent stem cell pancreatic differentiation model to elucidate the molecular mechanisms underlying HNF1B-associated diabetes and pancreatic hypoplasia. more...
#> 166                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             Bipolar disorder (BD) and obesity are highly comorbid. We previously performed a genome-wide association study (GWAS) for BD risk accounting for the  effect of body mass index (BMI) which identified a genome-wide significant single-nucleotide polymorphism (SNP) in the gene encoding the transcription factor 7 like 2 (TCF7L2). However, the molecular function of TCF7L2 in the central nervous system (CNS) and its possible role in BD and BMI interaction remained unclear. more...
#> 167                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             Bipolar disorder (BD) and obesity are highly comorbid. We previously performed a genome-wide association study (GWAS) for BD risk accounting for the  effect of body mass index (BMI) which identified a genome-wide significant single-nucleotide polymorphism (SNP) in the gene encoding the transcription factor 7 like 2 (TCF7L2). However, the molecular function of TCF7L2 in the central nervous system (CNS) and its possible role in BD and BMI interaction remained unclear. more...
#> 168                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Background: Tumor stage predicts pancreatic cancer (PDAC) prognosis, but prolonged and short survivals have been described in patients with early-stage tumors. Circulating microRNA (miRNA) are an emerging class of suitable biomarkers for PDAC prognosis. Our aim was to identify whether serum miRNA signatures predict survival of early-stage PDAC. Methods: Se-rum RNA from archival 15 stage I-III PDAC patients and 4 controls was used for miRNAs ex-pression profile (Agilent microarrays). more...
#> 169                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         Myometrial biopsies were collected from 31 women undergoing primary cesarean sections and were carefully phenotyped with respect to gestational age (GA), circumstances of labor onset, and clinical status at the start and end of the intervention. Cases were aggregated into groups as follows: Group 1: term birth following spontaneous onset of term labor (TL, n=5); Group 2: term birth by elective cesarean section not in labor (TNL, n=5); Group 3: PTB following spontaneous preterm labor with intact membranes (n=6); Group 4: preterm birth following PPROM (n=8); and Group 5: provider-initiated preterm birth in the absence of active labor contractions, cervical dilation or membrane rupture (n=7). more...
#> 170                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                This SuperSeries is composed of the SubSeries listed below.
#> 171                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Background: Cardiovascular disease had a global prevalence of 523 million cases and 18.6 million deaths in 2019.  The current standard for diagnosing coronary artery disease (CAD) is coronary angiography.  Surprisingly, despite well-established clinical indications, up to 40% of the one million invasive cardiac catheterizations return a result of ‘no blockage’.  The present studies employed RNA sequencing of whole blood to identify an RNA signature in patients presenting with a clinical suspicion of CAD. more...
#> 172                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Human pancreatic islets, including insulin secreting beta-cells are a major focus of transplantation strategies aimed at identifying new therapeutic approaches to counteract hyperglycemia in patients with diabetes. Identifying the transcriptomic signature of human islet cells provides insights into regulatory pathways that can be harnessed for planning therapeutic strategies. In this context, single-cell RNA-sequencing (scRNA-seq) has been used mostly in vitro. more...
#> 173                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          The objective of this study was to perform a global, non-targeted gene expression analysis by microarray, to understand the immune cell gene regulation at fasting and in response to oral glucose load and how this regulation is different in Asian-Indian men with normal glucose tolerance (NGT) and pre-diabetes (PD). Through observing real-time gene expression changes, this study highlights 1. the importance of acute metabolic challenges like oral glucose load in regulating the immune cell gene expression and function. more...
#> 174                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             In our genome-wide association study, we searched for an association of genetic variants with colorectal cancer, type 1 diabetes, Hodgkin lymphoma and  Diffuse large B-cell lymphoma among Polish population.
#> 175                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Stem and progenitor cells in the adult human pancreas provide an under-explored resource for regenerative medicine. Using micro-manipulation and methylcellulose-containing colony/organoid assays, we identified cells within the human cadaveric exocrine pancreas that fulfill the definition of a stem cell: able to self-renew and differentiate. Exocrine tissues were collected after the isolation of endocrine cells, dissociated into single cells, and plated into a 3-dimensional semisolid medium. We found that some pancreatic ductal cells gave rise to cystic colonies/organoids containing pancreatic duct, acinar, and endocrine lineage cells. These cells self-renewed and expanded approximately 300-fold over 9 weeks. When transplanted into diabetic mice, colonies/organoids lowered blood glucose levels and gave rise to insulin-expressing endocrine cells. Thus, stem/progenitor-like cells capable of self-renewal and differentiation either preexist in the adult human pancreas or readily adapt in culture. more...
#> 176                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Betel-nut consumption is the fourth most common addictive habit  globally and there is good evidence linking the habit to obesity, type 2 diabetes (T2D)  and the metabolic syndrome. The aim of our pilot study was to identify gene expression  relevant to obesity, T2D and the metabolic syndrome using a genome-wide  transcriptomic approach in a human monocyte cell line incubated with arecoline and its  nitrosated products.
#> 177                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   Generation of mature cells with stable functional identities is crucial for developing cell-based replacement therapies. Current global efforts to produce insulin-secreting beta-like cells to treat diabetes are hampered by the lack of tools to reliably assess cellular identity. We conducted a thorough single-cell transcriptomics meta-analysis to generate robust genesets defining the identity of human adult alpha-, beta-, gamma- and delta-cells. more...
#> 178                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               This study aimed to analyze the mutated genes of primary and recurrent SSs (PRSSs), to discover whether these sarcomas exhibit some potential mutated genes between primary and recurrent cases Illumina Infinium whole genome genotyping (WGG) arrays are increasingly being applied in cancer genomics to study gene copy number alterations and allele-specific aberrations such as loss-of-heterozygosity (LOH). more...
#> 179                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Purpose: To detect serum exosomal ncRNA profiles of proliferative diabetic retinopathy (PDR) by High-throughput sequencing Methods: serum exosomal non-coding RNA (ncRNA) profiles profiles of PDR and MH were generated by deep sequencing, only in once, using IlluminaHiSeq 3000. After analyzing the base composition and quality of the data, according to the analysis results of the original data, the data were filtered  to remove the joint sequence and the contaminated part, and to remove  low-quality base sequences.If it is paired-ended sequencing data, the filtered data should be further screened to retain the paired sequences and obtain clean data. more...
#> 180                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       Four male patients were enrolled for this study in collaboration with the Cardiology Unit of Policlinico Tor Vergata-Fondazione PTV (Rome). We have performed RNA-Sequencing using NextSeq 500 ILLUMINA platform on PBMCs of patients with clinically proven healthy coronary arteries (CTR) and patients with chronic coronary artery disease (CAD) confirmed by coronary angiography. RNA sequencing results showed differentially Altenative Splicing (AS) events and filtering for a statistically significant Splicing-Index Fold-Change≥ ±1.5 (p≤0.05) we observed 113 differentially regulated AS events (24 up and 89 down-regulated) from 86 genes. more...
#> 181                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Skeletal muscle accounts for the largest proportion of human body mass, on average, and is a key tissue in complex diseases and mobility. It is composed of several different cell and muscle fiber types. Here, we optimize single-nucleus ATAC-seq (snATAC-seq) to map skeletal muscle cell-specific chromatin accessibility landscapes in frozen human and rat samples, and single-nucleus RNA-seq (snRNA-seq) to map cell-specific transcriptomes in human. more...
#> 182                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Skeletal muscle accounts for the largest proportion of human body mass, on average, and is a key tissue in complex diseases and mobility. It is composed of several different cell and muscle fiber types. Here, we optimize single-nucleus ATAC-seq (snATAC-seq) to map skeletal muscle cell-specific chromatin accessibility landscapes in frozen human and rat samples, and single-nucleus RNA-seq (snRNA-seq) to map cell-specific transcriptomes in human. more...
#> 183                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                This SuperSeries is composed of the SubSeries listed below.
#> 184                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       We identified a novel lncRNA DRAIR that is downregulated in CD14+ monocytes from type 2 diabetes relative to controls. Functional studies showed that DRAIR regulates anti-inflammatory genes and its knockdown enhances proinflammatoory phentype of monocytes. To examine mechanisms of DRAIR actions, we performed Chromatin isolation by RNA purification (ChIRP) assays using DRAIR biotinylated tiling oligonucleotides to identify chromatin inding sites in THP-1 monocytes.
#> 185                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Monocyte activation by high glucose and free fatty acids promotes inflammation implicated in vascular complications associated with Type 2 diabetes (T2D). Emerging evidence shows that long non coding RNA (lncRNA)s regulate inflammation, but their  role in  T2D induced monocyte dysfunction is unclear. To examine this, we profiled the transcriptome of CD14+ monocytes from volunteers with T2D and without diabetes (n=5 each) using strand-specific RNA-seq on Illumina HiSeq 2500. more...
#> 186                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Genome wide DNA methylation profiling of cord blood cells obtained from gestational diabetes mellitus (GDM) pregnancies. The Illumina EPIC methylation beadchip array was used to obtain DNA methylation profiles across approximately 850,000 CpG dinucleotide methylation loci in DNA isolated from cord blood. Samples include 165 GDM subjects.
#> 187                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 Pancreatic beta cell senescence occurs during the development of Type 1  Diabetes. To model the transcriptional responses of islet cells to DNA damage, we previously developed a human islet culture model in which the DNA damage response and senescence can be induced via double strand-breaks with the agent bleomycin. Here, we report the transcriptome-wide changes in human pancreatic islet cells following bleomycin exposure.
#> 188                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        We investigated  the role of SNO-GNIA2 in HG+oxLDL-induced endothelial inflammation during the development of diabetes-accelerated atherosclerosis and found that SNO-GNAI2 could promote endothelial inflammation through dysregulating Hippo-YAP .  We hypothesized that SNO-GNAI2 induced Hippo-YAP dysfunction through enhancing coupling and activating  G-protein coupling receptors (GPCRs).
#> 189                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       We describe an unusual course of Ketosis Prone Diabetes and investigate potential mechanisms using induced pluripotent stem cell technology with high throughput mRNA sequencing and validation of a lecuine sensitive mTOR pathway.
#> 190                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Hyperhomocysteinemia (HHcy) is an established and potent independent risk factor for degenerative diseases, including cardiovascular disease (CVD), Alzheimer disease, type II diabetes mellitus, and chronic kidney disease. HHcy has been shown to inhibit proliferation and promote inflammatory responses in endothelial cells (EC), and impair endothelial function, a hallmark for vascular injury. However, metabolic processes and molecular mechanisms mediating HHcy-induced endothelial injury remains to be elucidated. more...
#> 191                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Hyperhomocysteinemia (HHcy) is an established and potent independent risk factor for degenerative diseases, including cardiovascular disease (CVD), Alzheimer disease, type II diabetes mellitus, and chronic kidney disease. HHcy has been shown to inhibit proliferation and promote inflammatory responses in endothelial cells (EC), and impair endothelial function, a hallmark for vascular injury. However, metabolic processes and molecular mechanisms mediating HHcy-induced endothelial injury remains to be elucidated. more...
#> 192                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          The aim of this study was to establish the exosomal miRNA profile across gestation in normal and GDM pregnancies and to determine the signaling pathways associated with the changes in the miRNA profile in GDM.
#> 193                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               Purpose: Whole-transcriptome sequencing technology and bioinformatics analysis were applied to systematically analyze the differentially expressed mRNAs, lncRNAs, circRNAs and miRNAs in adipose stem cells (ASCs) from diabetic, old and young patients. Methods: MRNAs, lncRNAs and cirRNAs profiles of adipose stem cells were generated by RNA sequencing, in triplicate, using Illumina HiSeq X Ten . MiRNAs profiles of adipose stem cells were generated by RNA sequencing, in triplicate, using BGISEQ-500. more...
#> 194                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Patients with hypertension alone, hypertension plus controlled diabetes and hypertension plus uncontrolled diabetes, and control patients without these conditions underwent coronary artery bypass grafting surgery. Skeletal muscle biopsy specimens were taken at the beginning ('pre-operative') and at the end ('post-operative') of the surgery.
#> 195                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Skeletal muscle aging is characterized by a progressive decline in muscle mass and function, which is referred to as sarcopenia. Aging is also a primary risk factor for metabolic syndrome (SX), which is a cluster of risk factors for cardiovascular diseases and type 2 diabetes. However, the molecular mechanisms implicated in sarcopenia and changes in muscle proteome associated with SX in elderly men remain unclear. more...
#> 196                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  The placenta is a highly heterogeneous organ and is closely related to adverse pregnancy. The previous bulk sequencing of whole tissue  could not show the characteristics of individual cells and the interactions between cells. Here, we select the placental tissues of the gestational diabetes group(GDM), preeclampsia group(PE), advanced age group(GL) and normal control group for single-cell sequencing in order to explain the mechanism of related diseases in more depth.nated spatial and temporal regulation of gene expression in the murine hindlimb determines the identity of mesenchymal progenitors and the development of diversity of musculoskeletal tissues they form. more...
#> 197                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Studies in rodents have shown obesity and aging impair tissue nicotinamide adenine dinucleotide (NAD+) biosynthesis, which contributes to metabolic dysfunction. The availability of nicotinamide mononucleotide (NMN) is an important rate-limiting factor in mammalian NAD+ biosynthesis. We conducted a 10-week, randomized, placebo-controlled, double-blind trial to evaluate the effect of NMN supplementation on metabolic function in 25 postmenopausal women with prediabetes who were overweight/obese. more...
#> 198                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       Recent clinical data has suggestedsed a bi-directional relationship  between Coronavirus disease 19 (COVID-19) and diabetes. Here, we showdemonstrateed the detection of SARS-CoV-2 in pancreatic endocrine cells in autopsy samples derived fromof COVID-19 patients. Single cell RNA-seq and immunostaining confirmed that multiple types of pancreatic islet cells can be infected byare susceptible to SARS-CoV-2, eliciting a cellular stress response and the induction of chemokines. more...
#> 199                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                This SuperSeries is composed of the SubSeries listed below.
#> 200                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Diabetic Retinopathy (DR) is among the major global causes for vision loss. With the rise in diabetes prevalence, an increase in DR incidence is expected. Current understanding of both the molecular etiology and pathways involved in the initiation and progression of DR is limited. Here we analyzed mRNA and miRNA expression profiles of 80 human post-mortem retinal samples from 80 patients diagnosed with various stages of DR. more...
#> 201                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Diabetic Retinopathy (DR) is among the major global causes for vision loss. With the rise in diabetes prevalence, an increase in DR incidence is expected. Current understanding of both the molecular etiology and pathways involved in the initiation and progression of DR is limited. Here we analyzed mRNA and miRNA expression profiles of 80 human post-mortem retinal samples from 80 patients diagnosed with various stages of DR. more...
#> 202                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             By functionally dissecting  densest enhancer cluster in the gene desert at 9P21 locus, we identified a non-redundant inter-dependent enhancer network that functions over long distances, the perturbation in any enhancer in the network results in the complete collapse of entire enhancer cluster and target genes activity. The enhancer network can be targeted to regulate INK4a/ARF locus in associated pathophysiologies and cancers.
#> 203                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          To gain insight into the history of islet cell deterioration along the progression from normal glycemic regulation to T2D, we collected surgical pancreatic tissue samples from 133 metabolically phenotyped pancreatectomized patients (PPP). Gene expression profiles of islets isolated by laser capture microdissection (LCM) from resected and snap-frozen pancreas samples were assessed by RNA sequencing.
#> 204                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                This SuperSeries is composed of the SubSeries listed below.
#> 205                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          High blood levels of free fatty acids link obesity with type-2 diabetes, but this connection remains poorly understood. We have investigated lipolysis and glucose homeostasis in recently diagnosed obese type-2 diabetics; in obese insulin resistant non-diabetic subjects (obese-IR) matched for age, sex, body composition and fasting insulin levels; and in healthy lean individuals. Our results show that obese-IR dissociate lipolysis from glycemic control, revealing that the action of compensatory hyperinsulinemia on blood glucose is not mediated by reduced lipolysis. more...
#> 206                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            In a randomized controlled trial, 82 older adults (>65y) with (or at risk of) undernutrition (n=82) were randomly allocated to 12 weeks of supplementation with a novel supplement (586 kcal, 22 g protein of which 50% whey and 50% casein, 206 mg ursolic acid, 7 g free BCAAs, 11 µg vitamin D) or standard care (600 kcal, 24g protein of which 100% casein, 4 µg vitamin D). Body weight increased significantly in the 12 weeks, both in the intervention group (+1.6 ± 0.2 kg, p<.0001) and in the standard care group (+1.8 ± 0.2 kg, p<.0001). more...
#> 207                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Despite the central role of chromosomal context in gene transcription, human noncoding DNA variants are generally studied outside of their endogenous genomic location. This limits our understanding of disease-causing regulatory variants. INS promoter mutations cause recessive neonatal diabetes. We studied 60 patients with such mutations, and show that all single base mutations disrupt a CC dinucleotide, while none affect elements important for INS promoter function in episomal assays. more...
#> 208                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Our transcriptomic phenotyping of pancreatic cell types provides novel insights into pancreas biology, as well as the initial pathogenic events in T1D.
#> 209                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                This SuperSeries is composed of the SubSeries listed below.
#> 210                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 A multi-omic approach in a clinical experimental study identified circulating biomarkers reflecting glucocorticoid exposure. Background: Endogenous glucocorticoids (GC) are mechanistically linked to common diseases and are important as drugs in the treatment of many disorders. There is no marker that can measure and quantify GC action. Our aim was to identify circulating biomarkers of GC action using a clinical experimental study. more...
#> 211                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 A multi-omic approach in a clinical experimental study identified circulating biomarkers reflecting glucocorticoid exposure. Background: Endogenous glucocorticoids (GC) are mechanistically linked to common diseases and are important as drugs in the treatment of many disorders. There is no marker that can measure and quantify GC action. Our aim was to identify circulating biomarkers of GC action using a clinical experimental study. more...
#> 212                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             Type 2 diabetes mellitus is mainly affected by genetic and environmental factors, and long noncoding RNAs (lncRNAs) have been shown to be correlated with diabetes.LncRNA is expected to be a target for the treatment and prediction of type 2 diabetes. We used microarrays to detail the lncRNAs and mRNAs expression in type 2 diabetes patients and healthy controls and obtained differentially expressed genes. more...
#> 213                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Over 90% of disease associated single nucleotide polymorphisms (SNPs) identified by genome wide association studies (GWAS) are noncoding variants. Platform to efficiently validate the biological function of variants thus discovered remain distinctly lacking. Here, we used β-like cells derived from isogenic human pluripotent stem cells (hPSCs), carrying the type 1 diabetes (T1D)-associated noncoding SNP rs2542151T>G or the knockout of the SNP-associated gene PTPN2−/−, to systematically examine the role of the T1D associated noncoding variant in β cell function and survival. more...
#> 214                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       Glucocorticoids are key regulators of glucose homeostasis and pancreatic islet function. In this study we used ATAC-seq and RNA-seq to map chromatin accessibility and gene expression from eleven primary human islet samples cultured in vitro with the glucocorticoid dexamethasone at multiple doses and durations. We identified thousands of accessible chromatin sites and genes with significant changes in activity in response to glucocorticoids. more...
#> 215                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  The objective of this study was to investigate whether placental exosomes in gestational diabetes mellitus (GDM) carries a specific set of miRNAs associated with skeletal muscle insulin sensitivity. Exosomes were isolated from chorionic villi-conditioned media and plasma from normal and GDM pregnancies. A specific set of miRNAs was identified to be selectively enriched within exosomes when compared to their cells of origin indicating specific packaging of miRNAs into exosomes. more...
#> 216                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       The aging of pancreatic beta-cells may undermine their ability to compensate for insulin resistance, leading to the development of type 2 diabetes (T2D). Aging beta-cells acquire markers of cellular senescence and develop a senescence-associated secretory phenotype (SASP) that can lead to senescence and dysfunction of neighboring cells through paracrine actions, contributing to beta-cell failure. Herein, we defined the beta-cell SASP signature based on unbiased proteomic analysis of conditioned media of cells obtained from human senescent beta-cells. more...
#> 217                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Genetic risk variants identified in genome-wide association studies (GWAS) of complex disease are primarily non-coding, and translating risk variants into mechanistic insight requires detailed gene regulatory maps in disease-relevant cell types. Here, we combined a GWAS of type 1 diabetes (T1D) in 520,580 samples with candidate cis-regulatory elements (cCREs) in pancreas and peripheral blood mononuclear cell types defined using single nucleus ATAC-seq (snATAC-seq) of 131,554 nuclei. more...
#> 218                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           Obesity is a major risk factor for a high number of secondary diseases, including cancer. Specific insights into the role of gender differences and secondary co-morbidities, such as type 2 diabetes (T2D) and cancer risk, are yet to be fully obtained. The aim of this study is thus to find a correlation between the transcriptional deregulation present in the subcutaneous adipose tissue of obese patients and the risk of cancer, in the presence of T2D, and considering gender differences. more...
#> 219                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                This SuperSeries is composed of the SubSeries listed below.
#> 220                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Introduction. Hindered by a limited understanding of the molecular mechanisms responsible for diabetic gastroenteropathy (DGE), patients are managed by symptom-based therapies.  We investigated the duodenal mucosal expression of protein-coding genes and miRNAs in DGE and related these abnormalities to clinical features. Methods. mRNA and micro RNA (miRNA) expression and ultrastructure of duodenal mucosal biopsies were investigated in 39 DGE patients and 21 healthy controls. more...
#> 221                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Introduction. Hindered by a limited understanding of the molecular mechanisms responsible for diabetic gastroenteropathy (DGE), patients are managed by symptom-based therapies.  We investigated the duodenal mucosal expression of protein-coding genes and miRNAs in DGE and related these abnormalities to clinical features. Methods. mRNA and micro RNA (miRNA) expression and ultrastructure of duodenal mucosal biopsies were investigated in 39 DGE patients and 21 healthy controls. more...
#> 222                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                This SuperSeries is composed of the SubSeries listed below.
#> 223                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           This study was designed to simulate the effect of hyperglycemia on the proximal tubule.  This portion of the kidney is responsible for reabsorption of the filtered glucose, and thus, the amount reabsorbed is not regulated by insulin.  A long-term exposure was designed to model aspects of renal demise seen in diabetes.  We utilized mortal cultures of human renal tubule epithelial cells isolated from renal cortical tissue. more...
#> 224                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        The association between T2 DM and BMSCs osteogenic differentiation has been documented in experimental settings. We examine miRNA expression specific for BMSCs from human jaw in Type 2 diabetics.
#> 225                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Single-cell RNAseq (10x Genomics) analysis of human CD4+ T cells in IPEX patients, healthy donors and heterozygous mothers (blood). Human CD4+T cells from IPEX, HD and mothers were isolated from frozen peripheral blood mononuclear cells by flow cytometry as DAPI–CD3+CD4+ cells. In cohort 1, cells from separate donor were encapsulated in separate channel following 10x Genomics Single Cell 3′ Reagent Kit (V2 chemistry). more...
#> 226                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       Mitochondrial respiration and gene expression related to mitochondrial function were measured from the peripheral blood of infection and sepsis patients as well as healthy controls
#> 227                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             Despite reduced function and volume of the exocrine pancreas in type 1 diabetes, literature describing the histology and the molecular biological profile in this area is limited. Here, the density of acinar cells was examined adjacent to and at varying distances from islets and the transcriptome was analyzed on laser capture microdissected (LCM) tissue from organ donors with and without type 1 diabetes. more...
#> 228                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               Islet function diminishes with age and as such the incidence of type 2 diabetes increases. The cause of this is unknown. In this study whole islets were extracted with laser capture microdissection from organ donors 1-81 years of age. Increasing age was associated with a downregulation of pathways associated with the cell cycle and increase in markers of senescence e.g. CDKN2A. Among novel genes increasing with age was SPP1.
#> 229                                                                                         Aims/hypothesis: Recurrent hypoglycaemia (RH) is a major side-effect of intensive insulin therapy for people with diabetes. Changes in hypoglycaemia sensing by the brain contribute to the development of impaired counterregulatory responses to and awareness of hypoglycaemia. Little is known about the intrinsic changes in human astrocytes in response to acute and recurrent low glucose (RLG) exposure.  Methods: Human primary astrocytes (HPA) were exposed to zero, one, three or four bouts of low glucose (0.1 mmol/l) for three hours per day for four days to mimic RH.  On the fourth day, DNA and RNA were collected. Differential gene expression and ontology analyses were performed using DESeq2 and GOseq respectively. DNA methylation was assessed using the Infinium MethylationEPIC BeadChip platform.  Results: 24 differentially expressed genes (DEGs) were detected (after correction for multiple comparisons). One bout of low glucose exposure had the largest effect on gene expression. Pathway analyses revealed that endoplasmic-reticulum (ER) stress-related genes such as HSPA5, XBP1, and MANF, involved in the unfolded protein response (UPR), were all significantly increased following LG exposure, which was diminished following RLG. There was little correlation between differentially methylated positions and changes in gene expression yet the number of bouts of LG exposure produced distinct methylation signatures.  Conclusions/interpretation: These data suggest that exposure of human astrocytes to transient LG triggers activation of genes involved in the UPR linked to endoplasmic reticulum (ER) stress. Following RLG, the activation of UPR related genes was diminished, suggesting attenuated ER stress. This may be mediated by metabolic adaptations to better preserve intracellular and/or ER ATP levels, but this requires further investigation.
#> 230                                                                                         Aims/hypothesis: Recurrent hypoglycaemia (RH) is a major side-effect of intensive insulin therapy for people with diabetes. Changes in hypoglycaemia sensing by the brain contribute to the development of impaired counterregulatory responses to and awareness of hypoglycaemia. Little is known about the intrinsic changes in human astrocytes in response to acute and recurrent low glucose (RLG) exposure.  Methods: Human primary astrocytes (HPA) were exposed to zero, one, three or four bouts of low glucose (0.1 mmol/l) for three hours per day for four days to mimic RH.  On the fourth day, DNA and RNA were collected. Differential gene expression and ontology analyses were performed using DESeq2 and GOseq respectively. DNA methylation was assessed using the Infinium MethylationEPIC BeadChip platform.  Results: 24 differentially expressed genes (DEGs) were detected (after correction for multiple comparisons). One bout of low glucose exposure had the largest effect on gene expression. Pathway analyses revealed that endoplasmic-reticulum (ER) stress-related genes such as HSPA5, XBP1, and MANF, involved in the unfolded protein response (UPR), were all significantly increased following LG exposure, which was diminished following RLG. There was little correlation between differentially methylated positions and changes in gene expression yet the number of bouts of LG exposure produced distinct methylation signatures.  Conclusions/interpretation: These data suggest that exposure of human astrocytes to transient LG triggers activation of genes involved in the UPR linked to endoplasmic reticulum (ER) stress. Following RLG, the activation of UPR related genes was diminished, suggesting attenuated ER stress. This may be mediated by metabolic adaptations to better preserve intracellular and/or ER ATP levels, but this requires further investigation.
#> 231                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               DNA methylation data throughout human muscle cell differentiation in n=14 individuals with type 2 diabetes and n=14 controls
#> 232                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             DNA methylation data for both proliferating myoblasts and differentiated myotubes from n=14 individuals with type 2 diabetes and n=14 controls
#> 233                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               mRNA expression data throughout human muscle cell differentiation in n=13 individuals with type 2 diabetes and n=13 controls
#> 234                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             mRNA expression data for both proliferating myoblasts and differentiated myotubes from n=13 individuals with type 2 diabetes and n=13 controls
#> 235                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                This SuperSeries is composed of the SubSeries listed below.
#> 236                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         Preterm or small for gestational age (SGA) infants are to be at high risk of noncommunicable diseases in adolescence, because they are exposed to hypoxia and malnutrition in and ex utero during perinatal period. Epigenetics could be one of the most important mechanisms of DOHaD.In the field of premature babies, previous studies investigated the methylation alterations related to gestational age and birthweight by using cord blood samples. more...
#> 237                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               We profiled scRNA-seq of 284 samples collected from 196 individuals, including 22 patients with mild/moderate symptoms, 54 hospitalized patients with severe symptoms, and 95 recovered convalescent persons, as well as 25 healthy controls. The samples were obtained from various tissue types, including human peripheral blood mononuclear cells (249), bronchoalveolar lavage fluid (12) and pleural pleural effusion (1)/sputum (22).
#> 238                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    We performed single cell transcriptomic analysis on 17 urine samples obtained from five subjects at two different occasions using both spot and 24-hour urine collection. In addition, we used a combined spot urine samples of five healthy individuals as a control sample. We sequenced a total of 71,667 cells. After quality control and downstream analysis, we found that epithelial cells were the most common cell types in the urine. more...
#> 239                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             We performed RNA-sequencing in uninfected, SARS-CoV-2-infected, and additionally remdesivir treated ex vivo cultured human islets from two donors to shed light on the transcriptional changes occurring upon viral infection.
#> 240                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         Previously, we developed a new model of diabetes-induced wound healing impairment in skin-humanized mice models that faithfully recapitulates the major histo-physiological features of such skin repair-deficient condition. Aiming to dissect the molecular mechanisms responsible for the delayed wound closure, global gene expression studies were performed.
#> 241                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                This SuperSeries is composed of the SubSeries listed below.
#> 242                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         Genome wide DNA Methylation in fetal cord blood and placenta from mother with GDM compared to mother with normal glucose tolerance
#> 243                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         Genome wide DNA Methylation in fetal cord blood and placenta from mother with GDM compared to mother with normal glucose tolerance
#> 244                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   Genetic variants associated with type 2 diabetes (T2D) risk affect gene regulation in metabolically relevant tissues, such as pancreatic islets. Here, we investigated contributions of regulatory programs active during pancreatic development to T2D risk. Interrogation of chromatin maps from developmental precursors throughout pancreatic differentiation of human embryonic stem cells (hESCs) identifies enrichment of T2D variants in pancreatic progenitor-specific stretch enhancers that are not active in islets. more...
#> 245                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            The increased usage of alternative Ayurvedic treatments as potential health-beneficial therapies emphasizes the importance of studying its efficacy in sound placebo-controlled intervention trials. An example of such a traditional Ayurvedic herbal preparation is Mohana Choorna, a mixture composed of 20 different herbs and used to prevent and treat type 2-diabetes (T2D). We studied the efficacy of “Mohana Choorna” on T2D-related parameters in subjects with impaired glucose tol-erance. more...
#> 246                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 Single-nucleus assay for transposase-accessible chromatin using sequencing (snATAC-seq) creates new opportunities to dissect cell type-specific mechanisms of complex diseases. Since pancreatic islets are central to type 2 diabetes (T2D), we profiled 15,298 islet cells by using combinatorial barcoding snATAC-seq and identified 12 clusters, including multiple alpha, beta and delta cell states. We cataloged 228,873 accessible chromatin sites and identified transcription factors underlying lineage- and state-specific regulation. more...
#> 247                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 Single-nucleus assay for transposase-accessible chromatin using sequencing (snATAC-seq) creates new opportunities to dissect cell type-specific mechanisms of complex diseases. Since pancreatic islets are central to type 2 diabetes (T2D), we profiled 15,298 islet cells by using combinatorial barcoding snATAC-seq and identified 12 clusters, including multiple alpha, beta and delta cell states. We cataloged 228,873 accessible chromatin sites and identified transcription factors underlying lineage- and state-specific regulation. more...
#> 248                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 Single-nucleus assay for transposase-accessible chromatin using sequencing (snATAC-seq) creates new opportunities to dissect cell type-specific mechanisms of complex diseases. Since pancreatic islets are central to type 2 diabetes (T2D), we profiled 15,298 islet cells by using combinatorial barcoding snATAC-seq and identified 12 clusters, including multiple alpha, beta and delta cell states. We cataloged 228,873 accessible chromatin sites and identified transcription factors underlying lineage- and state-specific regulation. more...
#> 249                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 Single-nucleus assay for transposase-accessible chromatin using sequencing (snATAC-seq) creates new opportunities to dissect cell type–specific mechanisms of complex diseases. Since pancreatic islets are central to type 2 diabetes (T2D), we profiled 15,298 islet cells by using combinatorial barcoding snATAC-seq and identified 12 clusters, including multiple alpha, beta and delta cell states. We cataloged 228,873 accessible chromatin sites and identified transcription factors underlying lineage- and state-specific regulation. more...
#> 250                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Type 2 diabetes mellitus (T2D), characterised by peripheral insulin resistance, is a risk factor for dementia. In addition to its contribution to small and large vessel disease, T2D may directly damage cells of the brain neurovascular unit. In this study, we investigated the transcriptomic changes in cortical neurones, and associated astrocytes and endothelial cells of the neurovascular unit, in the ageing brain
#> 251                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            It has been well established that the presence of diabetes is accompanied by a chronic inflammatory state promoting various diabetes-associated complications. One potential driver of this enhanced inflammatory state in patients with diabetes is hyperglycemia. Even after blood glucose control is achieved, diabetes-associated complications persist, suggesting the presence of a “hyperglycemic memory.” Innate immune cells, critically involved in various complications associated with diabetes, can build nonspecific, immunological memory (trained immunity) via epigenetic regulation. more...
#> 252                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Adipose tissue is found throughout the human body. The diversity of physiological specialization of fat depots is reflected in the depot-specific alterations seen in lipodystrophies and links between specific patterns of fat distribution and susceptibility to diseases, including Type II Diabetes. We compared gene expression patterns in seven anatomically diverse fat depots and in adipocytes and stromal-vascular cells isolated from each sample. more...
#> 253                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  We report the high-throughput miRNA sequencing of plasma isolated from human patients with type 2 diabetes & gastroparesis, idiopathic gastroparesis alone, and healthy control patients.
#> 254                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   Pericardial sac surrounding the heart contains pericardial fluid (PF), which is rich in exosomes. PF exosomes increase angiogenesis in hypoxic endothelial cells and in animal model of hindlimb ischemia by passing the proangiogenic miRNAs to recipient cells. However, under pathological conditions such as diabetes, exosome cargo composition changes and harmful miRNAs can be transferred to the recipient cells and induce more deleterious effects in target tissues. more...
#> 255                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Improving the early diagnosis and treatment of type 2 diabetes (T2D) can effectively control blood glucose. To investigate new long non-coding RNAs (lncRNAs) as molecular markers we used microarrays to identify differentially expressed lncRNAs and mRNAs in peripheral blood mononuclear cells from T2D patients and controls.
#> 256                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               Glucagon-like peptide-1 (GLP-1) is an incretin hormone that potentiates glucose  stimulated insulin secretion. GLP-1 is classically produced by gut L cells; however, under  certain circumstances alpha-cells can express the prohormone convertase required for  proglucagon processing to GLP-1, prohormone convertase 1/3 (PC1/3), and can produce  GLP-1. However, the mechanisms through which this occurs are poorly defined. more...
#> 257                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                This SuperSeries is composed of the SubSeries listed below.
#> 258                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      The downregulation of diabetes susceptibility gene GLIS3 contributes to pancreatic beta cell demise, at least in part, through downregulation of the  splicing factor SRSF6. Here, we used individual-nucleotide UV crosslinking and immunoprecipitation (iCLIP)  to map the RNA binding landscape of SRSF6 in pancreatic beta cells.
#> 259                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              The gene expression signature of the human kidney interstitium is not fully understood. Transcript expression of laser microdissected cortical interstitium (excluding tubules, glomeruli and large vessels) in 9 human reference nephrectomies was compared to 6 human diabetic kidney biopsy specimens. This transcriptomic data revealed novel interstitial markers and enrichment of relevant pathways. Analysis of diabetic interstitium uncovered genes with unchanged as well as down-regulated expression when compared to reference samples. more...
#> 260                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Glycemic control is a strong predictor of long-term cardiovascular risk in patients with diabetes mellitus, and poor glycemic control influences long-term risk of cardiovascular disease even decades after optimal medical management. This phenomenon, termed glycemic memory, has been proposed to occur due to stable programs of cardiac and endothelial cell gene expression. This transcriptional remodeling has been shown to occur in the vascular endothelium through a yet undefined mechanism of cellular reprogramming. more...
#> 261                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           Bulk RNA-sequencing of sorted CD8 T cells from recent-onset T1D subjects treated with alefacept.
#> 262                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 Idiopathic nodular mesangial sclerosis, also called idiopathic nodular glomerulosclerosis (ING) is a rare clinical entity with unclear pathogenesis. The hallmark of this disease is the presence of nodular mesangial sclerosis on histology without clinical evidence of diabetes mellitus or other predisposing diagnoses. To achieve insights into its pathogenesis, we queried the clinical, histopathologic and transcriptomic features of ING and nodular diabetic nephropathy (DN)
#> 263                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Comparative genomic hybridization analysis for detection of recurring gene copy number variation (CNV) among a set of lung cancer mestastatic brain tumors DNA was isolated and analyzed in a two-color experiment using Cancer CGH+SNP 180Kx4 arrays from Agilent and Agilent SureScan system: Cy5-labeled specimen DNA and Cy3-labeled Agilent characterized normal human reference DNA
#> 264                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is one of the leading causes of cancer-related deaths worldwide. The multi‐target inhibitor sorafenib is a first-line treatment for patients with advanced unresectable HCC. Recent clinical studies have evidenced that patients treated with sorafenib together with the anti-diabetic drug metformin have a survival disadvantage compared to patients receiving sorafenib only. more...
#> 265                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       Women with diabetes have a higher prevalence of cardiovascular complications than men, suggesting that sex-steroid hormones like estrogen may impact on female health in diabetes. Here we demonstrate that estrogen suppletion and insulin resistance in male-to-female transgenders coincides with lower plasma levels of miR-224 and miR-452 carried in extracellular vesicles. Systemic silencing of miR-224 and miR-452 in mice triggered a prediabetic phenotype with higher plasma insulin levels, increased white adipose lipogenesis and less glucose uptake and mitochondrial respiration in brown adipose tissue. more...
#> 266                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           This study aimed to examine the postprandial transcriptome of adipose tissue middle-aged men selectively recruited on the basis of MetS (defined by the International Diabetes Federation (IDF) criteria) and healthy control participants. Two breakfast meals that provided different macronutrient composition, and were indicative of major patterns of dietary habits (animal-based versus plant-based) were given, postprandial adipose gene expression was measured by microarray at fasting (0 h) and 4 hours post-meal.
#> 267                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       Transcriptional profiling of human PBMCs comparing healthy controls, patients with diabetic nephropathy and patients with ESRD. PBMCs were analyzed as they mediate inflammatory injury. Goal was to determine effects of increasing severity of diabetic nephropathy on global PBMC gene expression. Microarray analysis of PBMCs taken from patients with varying degrees of diabetic nephropathy.
#> 268                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            We previously reported a child with transient neonatal diabetes mellitus (TNDM), who upon molecular diagnosis was homozygous for a one base-pair deletion in ZFP57, inheriting the mutations from both heterozygous parents. Methylation profiling at diagnosis revealed severe hypomethylation at PLAGL1 and mosaic loss-of-methylation (LOM) at GRB10, NAP1L5 and GNAS-XL DMRs.  Some years after the first child, a second sibling was born with a comparable clinical presentation. more...
#> 269                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Understanding the process of immune remodeling and regulation in SARS-CoV-2 infected patients from hospitalization to rehabilitation is crucial for therapy of patients with COVID-19. Here, we performed a longitudinal whole-transcriptome RNA sequencing on peripheral blood mononuclear cell (PBMC) samples of 18 patients with mild, moderate or severe COVID-19 symptoms during the treatment, convalescence and rehabilitation stages. more...
#> 270                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         Maternal metabolic disorders such as obesity and diabetes are detrimental factors that compromise fertility and the success rates of medically assisted procreation (MAP) procedures. During metabolic stress, adipose tissue is more likely to release free fatty acids (FFA) in the serum resulting in an increase of FFA levels not only in blood, but also in follicular fluid (FF). In humans, high concentrations of palmitic acid (PA) and stearic acid (SA) reduced granulosa cell survival and were associated with poor cumulus-oocyte complex (COC) morphology. more...
#> 271                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  The aim of this study was therefore to investigate molecular mechanisms associated with insulin sensitivity in skeletal muscle by relating global skeletal muscle gene expression with a surrogate measure of insulin sensitivity, i.e. homeostatic model assessment of insulin resistance (HOMA-IR). To identify genes with skeletal muscle expression related to insulin sensitivity, we obtained muscle biopsies from 38 non-diabetic participants in study A. more...
#> 272                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       We studied 9 healthy young non-diabetic men without any family history of diabetes. The mean age and body mass index (BMI) were 25.33 ± 0.33 years and 24.57 ± 0.62 kg/m2, respectively, and the mean 1/ homeostatic model assessment of insulin resistance (HOMA-IR) was 1.17 ± 0.12. We included baseline gene expression profile data (i.e. only before bed rest)
#> 273                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    To identify genes correlated to insulin sensitivity in skeletal muscle, we studied 38 non-diabetic men from Malmö, Sweden. Briefly, the Malmö Exercise Intervention cohort consists of sedentary but otherwise healthy male subjects from southern Sweden. They all have European ancestry and 18 of them have a first-degree family member with T2D. The mean age and body mass index (BMI) were 37.71 ± 0.71 years and 28.47 ± 0.48 kg/m2, respectively, and the mean 1/the homeostatic model assessment-insulin resistance (HOMA-IR) was 0.69 ± 0.04
#> 274                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         The mechanisms underlying Roux-en-Y gastric bypass (RYGB) surgery-induced weight loss and the immediate postoperative beneficial metabolic effects associated with the operation remain uncertain. We aimed to identify novel gut-derived peptides with therapeutic potential in obesity and/or diabetes by determining genome-wide expression patterns in isolated human small intestinal enteroendocrine cells (EECs) obtained from 20 obese subjects undergoing RYGB and again three months later by upper enteroscopy. more...
#> 275                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             RNA-seq data of monocyte-derived human Dendritic cells (huDCs) cultured with PSAB-liposomes and/or Liraglutide
#> 276                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Genome-wide DNA methylation profiling of umbilical cord blood buffy coat DNA samples. The Illumina Infinium MethylationEPIC array was used to obtain DNA methylation profiles across approximately 850,000 CpGs. Samples included 557 cord blood samples born to obese women in the UPBEAT trial, with and without gestational diabetes mellitus (GDM), to determine the association between maternal GDM and hyperglycaemia during pregnancy on the methylation in the infant.
#> 277                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                This SuperSeries is composed of the SubSeries listed below.
#> 278                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 We report novel epigenetic mechanisms of epigenetic memory and its role in regulation of transporter genes in diabetic renal proximal tubules. We have generated RNA-seq, ATAC-seq and Infinium EPIC methylation array datasets from human primary proximal tubule epithelial cells from non-diabetic healthy controls and from patients with history of Type II Diabetes.
#> 279                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  We report novel epigenetic mechanisms of epigenetic memory and its role in regulation of transporter genes in diabetic renal proximal tubules. We have generated RNA-seq, ATAC-seq and Infinium EPIC methylation array datasets from human primary proximal tubule epithelial cells from non-diabetic healthy controls and from patients with history of Type II Diabetes. Analyses of RNA-seq, ATAC-seq and Methylaiton EPIC array data.
#> 280                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Deglycosylated-leucine-rich α-2-glycoprotein1 (DG-LRG1) as well as LRG1 was discovered to promote angiogenesis under diabetes mellitus condition through TGF-β independent binding to endoglin. To examine the signaling pathways triggered by DG-LRG1, we subjected whole-cell protein lysates of control and DG-LRG1 treated HUVECs to a Phospho Explorer antibody array analysis using commercial antibody array assay kit (Full Moon Biosystems, Inc.). more...
#> 281                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Pancreatic β-cell failure is key to type 2 diabetes (T2D) onset and progression. We assessed whether human β-cell dysfunction induced by metabolic stress is reversible, evaluated the molecular pathways underlying persistent or transient damage, and explored the relationships with T2D islet traits. Twenty-six human islet preparations were exposed to several lipo- and/or glucotoxicity conditions, some of which impaired insulin release depending on stressor type, concentration and combination. more...
#> 282                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         Persons with HIV have a disproportionate burden of metabolic disease, including type 2 diabetes. We hypothesized that the accumulation of chronically activated T cells in the adipose tissue of HIV+ persons is a central mechanism promoting local macrophage activation, impaired adipocyte function, and the development of HIV-associated glucose intolerance. Prior studies of immune activation and HIV-associated metabolic disease have only measured circulating T cell subsets. more...
#> 283                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                This SuperSeries is composed of the SubSeries listed below.
#> 284                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             Although analysis of maternal plasma cell-free content has been employed for screening of genetic abnormalities within a pregnancy, limited attention has been paid to its use for the detection of adverse pregnancy outcomes (APOs) based on placental function. We investigated the cell-free RNA content of 102 maternal, 25 cord plasma samples and 7 non pregnant women as control. using cell-free RNA sequencing, APOs revealed seventy-one differentially expressed genes early in pregnancy. more...
#> 285                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Although analysis of maternal plasma cell-free content has been employed for screening of genetic abnormalities within a pregnancy, limited attention has been paid to its use for the detection of adverse pregnancy outcomes (APOs) based on placental function. Here we investigated cell-free DNA and RNA content of 102 maternal and 25 cord plasma samples. Employing a novel deconvolution methodology, we found that during the first trimester, placenta-specific DNA increased prior to the subsequent development of gestational diabetes with no change in patients with preeclampsia while decreasing with maternal obesity. more...
#> 286                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 Obesity and type 2 diabetes (T2D) can be associated with altered secretion of enterohormones in condition that remains to be understood in depth. Here, we aimed to decipher the mechanisms by which a major enterohormone GLP-1, is decreased in human obese patients according to their diabetic status.
#> 287                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       Metformin is a classic type II diabetes drug which has possessed anti-tumor properties for various cancers. However, different cancers do not respond to metformin with the same effectiveness or acquire resistance. Thus, searching for vulnerabilities of metformin-resistant prostate cancer is a promising strategy to improve the therapeutic efficiency. A genome-scale CRISPR-Cas9 activation library targeting 23430 genes is conducted to identify the genes that confer resistance to metformin in prostate cancer cells.
#> 288                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Diabetes mellitus is associated with serious long-term complications, including increased cardiovascular risk and a higher occurrence of infections. These diabetes-related complications are suggestive of altered responses of the innate immune system. Recent studies have shown that energy metabolism of monocytes is a crucial determinant of their functionality. Here we investigate whether metabolism and function of monocytes are changed in patients with diabetes and aim to identify diabetes-associated factors driving these alterations. more...
#> 289                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Dedifferentiation of pancreatic beta cells may reduce islet function in type 2 diabetes (T2D). However, the prevalence, plasticity and functional consequences of this cellular state remain unknown.  We employed single-cell RNAseq to detail the maturation program of alpha and beta cells during human ontogeny. We show that although both alpha and beta cells mature in part by repressing non-endocrine genes, alpha-cells retain hallmarks of an immature state, while beta-cells attain a full beta-cell specific gene expression program. more...
#> 290                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             In vitro differentiation of human ES cells into insulin-producing β-like cells offers new opportunities for pancreatic development modeling and potential diabetes therapy. However, the precise molecular events associated with this multi-stage process remain unclear. Here, we generated 95,308 single cell transcriptome data encompassing the entire differentiation process, and reconstructed a tree delineating the fate choices of all major cell populations in both endocrine and non-endocrine lineages. more...
#> 291                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         Type 1 diabetes (T1D) is characterized by immune mediated destruction of insulin producing β cells. Biomarkers capable of identifying T1D risk and dissecting disease-related heterogeneity represent an unmet clinical need. Aims: Towards the goal of informing T1D biomarker strategies, we profiled different classes of RNAs in human islet-derived exosomes and identified RNAs that were differentially expressed under cytokine stress conditions. more...
#> 292                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 We performed RNA-seq on tissue biopsies derived from patients with DFUs and compared it to human oral and skin wounds to identify the molecular mechanisms and transcriptional networks that are deregulated in DFUs. Our results identified a unique inflammatory transcriptional signature unique to oral and skin wounds involved in promoting cell proliferation and cell survival of immune cells that are deficient in DFUs. more...
#> 293                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   Immune responses in lungs of Coronavirus Disease 2019 (COVID-19) are poorly characterized. We conducted transcriptomic, histologic and cellular profiling of post mortem COVID-19 and normal lung tissues. Two distinct immunopathological reaction patterns were identified. One pattern showed high expression of interferon stimulated genes (ISGs) and cytokines, high viral loads and limited pulmonary damage, the other pattern showed severely damaged lungs, low ISGs, low viral loads and abundant immune infiltrates. more...
#> 294                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          We investigated whether circulating microRNAs (miRNAs) are associated with residual insulin secretion at diagnosis and predict the severity of its future decline. We studied 53 newly diagnosed subjects enrolled in placebo groups of TrialNet clinical trials.  We measured serum levels of 2,083 miRNAs using RNAseq technology, in fasting samples from the baseline visit (<100 days from diagnosis), during which residual insulin secretion was measured with a mixed meal tolerance test (MMTT). more...
#> 295                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Histone deacetylases (HDACs) are important regulators of epigenetic gene modification that are involved in the transcriptional control of metabolism. In particular class IIa HDACs have been shown to affect hepatic gluconeogenesis and previous approaches revealed that their inhibition reduces blood glucose in type 2 diabetic mice. In the present study, we aimed to evaluate the potential of class IIa HDAC inhibition as a therapeutic opportunity for the treatment of metabolic diseases. more...
#> 296                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      IL-12 and IL-18 synergize to promote TH1 responses and have been implicated as accelerators of autoimmune pathogenesis in type 1 diabetes (T1D). We therefore investigated the influence of these cytokines on phenotype and function of immune cells that are involved in disease progression. To understand how IL-12 and IL-18 may synergize to impair Treg function and phenotype, we conducted transcriptional profiling of Treg expanded under normal conditions or in the presence of IL-12 and IL-18. more...
#> 297                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         We identified that PBMC of individuals simultaneously affected by a combination of T2DM, dyslipidemia and periodontitis, showed altered molecular profile mainly associated to inflammatory response, immune cell trafficking, and infectious disease pathways Patients were divided into: T2DMpoorly-DL-P (n=5, Grupo 1), T2DMwell-DL-P (n=7, Grupo 2), DL-P (n=6, Grupo 3), P (n=6, Grupo 4) and Healthy (n=6, Control). more...
#> 298                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          The growth hormone plays a significant role in normal renal function and overactive growth hormone signaling has been implicated in proteinuria in diabetes. Earlier studies from our group have shown that the glomerular podocytes, which play an essential role in renal filtration, express the growth hormone receptor, suggesting the direct action of growth hormone on these cells. Nevertheless, the precise mechanism and the downstream pathways that are induced by the excess growth hormone in these podocytes leading to diabetic nephropathy are not clearly established. more...
#> 299                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       The incidence of new onset diabetes after transplant (NODAT) has increased over the past decade, likely due to calcineurin inhibitor-based immunosuppressants, including tacrolimus (TAC) and cyclosporin (CsA). Voclosporin (VCS), a next generation calcineurin inhibitor is reported to cause fewer incidences of NODAT but the reason is unclear. Whilst calcineurin signaling plays important roles in pancreatic beta-cell survival, proliferation, and function, its effects on human beta-cells remain understudied. more...
#> 300                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                This SuperSeries is composed of the SubSeries listed below.
#> 301                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             We perfomed transcriptomic and methylomic analysis of sural nerve biopsies from type 2 diabetic patients with neuropathy. Sural nerve transcriptomic and methylomic profiles were integrated and subsequent biological meaning investigated using KEGG pathway analysis of overlapping differentially expressed genes (DEGs) and differentially methylated genes (DMGs). A gene interation network was also generated including DEGs and DMGs, and common biological pathways were identified.
#> 302                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             We perfomed transcriptomic and methylomic analysis of sural nerve biopsies from type 2 diabetic patients with neuropathy. Sural nerve transcriptomic and methylomic profiles were integrated and subsequent biological meaning investigated using KEGG pathway analysis of overlapping differentially expressed genes (DEGs) and differentially methylated genes (DMGs). A gene interation network was also generated including DEGs and DMGs, and common biological pathways were identified.
#> 303                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 Gene expression plasticity is central for macrophages? timely responses to cues from the microenvironment permitting phenotypic adaptation from pro-inflammatory (M1) to wound healing and tissue-regenerative (M2, with several subclasses). Regulatory macrophages (Mreg) are a distinct macrophage type, partially sharing some functionalities with both M1 and M2 cells. Mreg possess immunoregulatory, anti-inflammatory, and angiogenic properties, and are considered as a potential allogeneic cell therapy product to treat clinical conditions, e.g., non-healing diabetic foot ulcers. more...
#> 304                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                This SuperSeries is composed of the SubSeries listed below.
#> 305                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Background: Cold acclimation and exercise training were previously shown to increase peripheral insulin sensitivity in human volunteers with type 2 diabetes. Although cold is a potent activator of brown adipose tissue, the increase in peripheral insulin sensitivity by cold is largely mediated by events occurring in skeletal muscle and at least partly involves GLUT4 translocation, as is also observed for exercise training. more...
#> 306                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Background: Cold acclimation and exercise training were previously shown to increase peripheral insulin sensitivity in human volunteers with type 2 diabetes. Although cold is a potent activator of brown adipose tissue, the increase in peripheral insulin sensitivity by cold is largely mediated by events occurring in skeletal muscle and at least partly involves GLUT4 translocation, as is also observed for exercise training. more...
#> 307                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Chromatin-associated RNA (caRNA) has been proposed as a type of epigenomic modifier. Here, we test whether environmental stress can induce cellular dysfunction through modulating RNA-chromatin interactions. We induce endothelial cell (EC) dysfunction with high glucose and TNFα (H + T), that mimic the common stress in diabetes mellitus. We characterize the H + T-induced changes in gene expression by single cell (sc)RNA-seq, DNA interactions by Hi-C, and RNA-chromatin interactions by iMARGI. more...
#> 308                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Chromatin-associated RNA (caRNA) has been proposed as a type of epigenomic modifier. Here, we test whether environmental stress can induce cellular dysfunction through modulating RNA-chromatin interactions. We induce endothelial cell (EC) dysfunction with high glucose and TNFα (H + T), that mimic the common stress in diabetes mellitus. We characterize the H + T-induced changes in gene expression by single cell (sc)RNA-seq, DNA interactions by Hi-C, and RNA-chromatin interactions by iMARGI. more...
#> 309                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Chromatin-associated RNA (caRNA) has been proposed as a type of epigenomic modifier. Here, we test whether environmental stress can induce cellular dysfunction through modulating RNA-chromatin interactions. We induce endothelial cell (EC) dysfunction with high glucose and TNFα (H + T), that mimic the common stress in diabetes mellitus. We characterize the H + T-induced changes in gene expression by single cell (sc)RNA-seq, DNA interactions by Hi-C, and RNA-chromatin interactions by iMARGI. more...
#> 310                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                This SuperSeries is composed of the SubSeries listed below.
#> 311                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Chromatin-associated RNA (caRNA) has been proposed as a type of epigenomic modifier. Here, we test whether environmental stress can induce cellular dysfunction through modulating RNA-chromatin interactions. We induce endothelial cell (EC) dysfunction with high glucose and TNFα (H + T), that mimic the common stress in diabetes mellitus. We characterize the H + T-induced changes in gene expression by single cell (sc)RNA-seq, DNA interactions by Hi-C, and RNA-chromatin interactions by iMARGI. more...
#> 312                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Chromatin-associated RNA (caRNA) has been proposed as a type of epigenomic modifier. Here, we test whether environmental stress can induce cellular dysfunction through modulating RNA-chromatin interactions. We induce endothelial cell (EC) dysfunction with high glucose and TNFα (H + T), that mimic the common stress in diabetes mellitus. We characterize the H + T-induced changes in gene expression by single cell (sc)RNA-seq, DNA interactions by Hi-C, and RNA-chromatin interactions by iMARGI. more...
#> 313                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Chromatin-associated RNA (caRNA) has been proposed as a type of epigenomic modifier. Here, we test whether environmental stress can induce cellular dysfunction through modulating RNA-chromatin interactions. We induce endothelial cell (EC) dysfunction with high glucose and TNFα (H + T), that mimic the common stress in diabetes mellitus. We characterize the H + T-induced changes in gene expression by single cell (sc)RNA-seq, DNA interactions by Hi-C, and RNA-chromatin interactions by iMARGI. more...
#> 314                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Background: Prolonged exposure to elevated free fatty acids induces β-cell failure (lipotoxicity) and contributes to the pathogenesis of type 2 diabetes. In vitro exposure of β-cells to the saturated free fatty acid palmitate is a valuable model of lipotoxicity, reproducing features of β-cell failure observed in type 2 diabetes. In order to map the β-cell response to lipotoxicity, we combined RNA-sequencing of palmitate-treated human islets with iTRAQ proteomics of insulin-secreting INS-1E cells following a time course exposure to palmitate. more...
#> 315                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Circulating cell-free unmethylated DNA fragments arising from the human INS gene have been proposed as biomarkers of β-cell death for the presymptomatic detection of diabetes. However, given the variability of CpG methylation in the INS gene in different cell types, this gene alone may not yield sufficiently specific information to unambiguously report β-cell damage. We employed an unbiased approach using data from a human DNA methylation gene array to identify the CHTOP gene as a candidate biomarker whose CpGs show a greater frequency of unmethylation in human islets. more...
#> 316                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Proliferative diabetic retinopathy (PDR) is the advanced stage of diabetic retinopathy (DR), coupling with irregular neovascularization, and is the leading cause of blindness in working-age people; but the molecular mechanism of vascular differentiation in PDR remains poorly characterized. In our study, we obtained the transcriptome profile of neovascular proliferative membrane specimens from patients with PDR via high-throughput sequencing and advanced bioinformatics. more...
#> 317                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           Metabolic syndrome, whose main diagnostic component is obesity, is a risk factor for lifestyle-related diseases, type 2 diabetes, and cardiovascular disease. Diet is known to affect the prevalence of metabolic syndrome. However, the effect of diet on metabolic syndrome in Japanese subjects has not been thoroughly explored. In the present study, we investigated the effect of carotenoid-rich vegetables, particularly lycopene- and lutein-rich vegetables, on the metabolic syndrome in obese Japanese men. more...
#> 318                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Autoimmune destruction of pancreatic β cells underlies type 1 diabetes (T1D). To understand T-cell mediated immune impact on human pancreatic β cells, we combine β cell specific expression of a model antigen CD19 and anti-CD19 chimeric antigen receptor T (CAR-T) cells. Co-culturing CD19-expressing -like cells and CD19 CAR-T cells results in T-cell mediated β-like cell death with release of activated T cell cytokines. more...
#> 319                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          LncRNAs are developmentally regulated and highly cell type-specific non-coding RNAs that have emerged as important regulators of cell fate commitment and maintenance. In this study, we dissected the role of lncRNAs in human pancreas development by classifying lncRNAs based on their dynamic regulation, subcellular localization, and engagement with ribosomes during the stepwise differentiation of human embryonic stem cells (hESCs) towards pancreatic fate. more...
#> 320                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       Diabetic foot ulcers (DFUs) and associated impaired healing, represent a major problem, that significantly impairs the quality of life of diabetic patients, leading to prolonged hospitalization and resulting in more than 70,000 lower extremity amputations per year in the USA alone. In the present study, we prospectively followed a large group of DFU patients for 12 weeks and aimed to identify systemic and local factors that are associated with DFU healing. more...
#> 321                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Brown adipocytes (BAs) are a potential therapeutic cell source for the treatment of metabolic disease such as type 2 diabetes. In this report, human pluripotent stem cells (hPSCs) are subject to directed differentiation to brown dipocytes through a paraxial mesoderm intermediate at high-efficiency. RNA-Seq and ATAC-seq was performed to characterized hPSCs derived paraxial mesoderm and brown adipocytes generated in this study.
#> 322                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      TCF7L2 rs290487 C allele increases diabetic risk in Chinese, however the mechanism remains unclear. We herein evaluated the role of rs290487 variant in hepatic glucose homeostasis by integrating clinical and multi-omics data (ChIP-seq, ATAC-seq, RNA-seq, and metabolomics) from CRISPR/Cas9 edited PLC-PRF-5 cell lines (C/C vs. C/T). In clinical cohort, C/C genotype was associated with higher insulin resistance index and higher incidence of hepatogenous diabetes as compared to C/T heterozygote and T/T homozygote genotypes. more...
#> 323                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Excessive mitochondrial fission plays a key role in podocyte injury in diabetic kidney disease (DKD), and long noncoding RNAs (lncRNAs) are important in the development and progression of DKD. However, lncRNA regulation of mitochondrial fission in podocytes is poorly understood. Here, we want to identify how lncRNA changes in human podocytes cultured with high glucose.
#> 324                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 Diabetes is characterized by hyperglycemia, loss of functional islet beta cell mass, deficiency of glucose-lowering insulin, and persistent alpha cell secretion of gluconeogenic glucagon. Still, no therapies that target these underlying processes are available. We therefore performed high-throughput screening of 300,000 compounds and extensive medicinal chemistry optimization and here report the discovery of SRI-37330, an orally bioavailable, non-toxic small molecule, which effectively rescued mice from streptozotocin- and obesity-induced (db/db) diabetes. more...
#> 325                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       Interest in human brown fat as a novel therapeutic target to tackle the growing obesity and diabetes epidemic has increased dramatically in recent years. While much insight into brown fat biology has been gained from murine cell lines and models, few resources are available to study human brown fat in-vitro. In this study, we detail the derivation and characterization of a novel human ES UCP1 reporter cell line that marks UCP1 positive adipocytes in-vitro. more...
#> 326                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Common genetic traits are not well defined in hepatocellular carcinoma (HCC), because necroinflammation lasting long in prior to hepatocarcinogenesis embeds highly heterogenous genetic background in hepatocytes over the liver. We experienced a rare case with chronic hepatitis C, in which multiple liver tumors at different stages in multistep hepatocarcinogenesis were observed at the same time. Under the same genetic and etiological backgrounds, comparisons of expression profiles among dysplastic nodules (DN), well differentiated HCC (WEL), and moderately differentiated HCC (MOD) would provide critical genetic information for the initiation and progression of HCC.
#> 327                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         The aim of this study was to conduct a baseline comparison of serum-circulating miRNA in prediabetic individuals with the distinction between those who later progressed to type 2 diabetes (T2DM) and those who did not. The expression level of 798 miRNAs using NanoString technology was examined. Spearman correlation, ROC curve analysis, and logistic regression modeling were performed. Gene ontology (GO), canonical pathways analysis were used to explore the biological functions of the miRNA target genes. more...
#> 328                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Four miRNAs showed significantly different expression post-vitamin C supplementation including the down-regulation of miR-451a, and up-regulation of miR-1253, miR-1290 and miR-644a. Subsequent validation study showed only miR-451a expression was significantly different with supplementation.
#> 329                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           Donor pancreata were obtained from the Beta Cell Bank of the JDRF Centre for Beta Cell Therapy in Diabetes (Brussels, Belgium), from Pancreatic Islet Processing (ECIT center) of Diabetes Research Institute at the IRCCS San Raffaele Scientific Institute (Milan, Italy) and from the DRWF Human Islet Isolation Facility (Oxford, England). Full written consent for use of donor material for research was obtained according to Belgian, Italian and English laws. more...
#> 330                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           Donor pancreata were obtained from the Beta Cell Bank of the JDRF Centre for Beta Cell Therapy in Diabetes (Brussels, Belgium), from Pancreatic Islet Processing (ECIT center) of Diabetes Research Institute at the IRCCS San Raffaele Scientific Institute (Milan, Italy) and from the DRWF Human Islet Isolation Facility (Oxford, England). Full written consent for use of donor material for research was obtained according to Belgian, Italian and English laws. more...
#> 331                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                People living with diabetes have an increased risk of developing active tuberculosis. The effects of diabetes (HbA1c ≥6.5%) and intermediate hyperglycaemia (HbA1c 5.7-6.5%), on this transcriptomic signature were investigated by RNA-seq, to enhance understanding of immunological susceptibility in diabetes-tuberculosis comorbidity.Diabetes increased the magnitude of gene expression change in the host transcriptome in tuberculosis, characterised by an increase in innate, and decrease in adaptive immune responses. more...
#> 332                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Metformin, a biguanide agent, is the first-line treatment for type 2 diabetes mellitus due to its glucose-lowering effect. Despite its wide application in the treatment of multiple health conditions, the glycemic response to metformin is highly variable, emphasizing the need for reliable biomarkers.   We chose the RNA-Seq-based comparative transcriptomics approach to evaluate the systemic effect of metformin and highlight potential predictive biomarkers of metformin response in drug-naïve type 2 diabetes patient volunteers in vivo. more...
#> 333                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Purpose: The goal of this study is to characterize the gene expression profiles and identify genes of interest (GOI) in stenotic (AS) and regurgitant (AI) human aortic valves using RNA sequencing technology. Methods: Aortic valve leaflets were collected from non-matched transplant donor hearts (NC) and from aortic valve replacement operations (AS or AI).  Leaflets were washed in cold PBS, snap frozen, and stored at -80°C until RNA extraction. more...
#> 334                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Long noncoding RNAs (lncRNAs) is already evidently involved in a variety of biological functions and pathophysiological mechanisms underlying the diabetes. However, the role of lncRNAs in the type 2 diabetes (T2D) has not been explored clearly yet. The aim of this study was to determine the circulating lncRNA profile and confirmed the differentially expressed lncRNA between T2D patients.
#> 335                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           PURPOSE: To investigate the circulatory microRNA (miRNA) profiles of aqueous, vitreous, and plasma in order to identify biomarkers in aqueous humor or plasma that are reflecting changes in vitreous of patients with diabetes. METHODS:  Aqueous, vitreous and plasma samples were collected from a total of 27 patients - 11 controls (macular pucker or macular hole patients) and 16 patients with diabetes mellitus (DM) undergoing vitreoretinal surgery:  DM-Type I with proliferative diabetic retinopathy (PDR) (DMI-PDR), DM Type II with PDR (DMII-PDR) and DM Type II with nonproliferative DR (DMII-NPDR). more...
#> 336                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   To determine ceRNA transcribed during the PBMCs, we have employed whole genome microarray expression profiling as a discovery platform to identify ceRNA expression in PBMCs donated by T1DM (type 1 diabetes mellitus) patients and healthy volunteers.
#> 337                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   To determine miRNA transcribed during the PBMCs, we have employed whole genome microarray expression profiling as a discovery platform to identify miRNA expression in PBMCs donated by T1DM (type 1 diabetes mellitus) patients and healthy volunteers.
#> 338                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               Background: Traditionally, the transcriptomic and proteomic characterisation of CD4+ T cells at the single-cell level has been performed by two largely exclusive types of technologies: single-cell RNA-sequencing (scRNA-seq) and antibody-based cytometry. Here we present a multi-omics approach allowing the simultaneous targeted quantification of mRNA and protein expression in single-cells and investigate its performance to dissect the heterogeneity of human immune cell populations. more...
#> 339                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Obesity is a major public health burden worldwide, greatly increasing the risk of diabetes, cardiovascular diseases and cancer. Obesity and associated insulin resistance are characterized by chronic low-grade inflammation driven by the cooperation of the innate immune system and dysregulated metabolism in adipose tissue and other metabolic organs. RIPK1 (Receptor-Interacting serine/threonine Protein Kinase 1) is a central regulator of inflammatory cell function that coordinates inflammation, apoptosis and necroptosis in response to inflammatory stimuli. more...
#> 340                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          We collected the mid-morning urine samples, and centrifuged at 2000g for ten minutes in order to remove cells and debris, and then stored in -80 degree refrigerator. we selected 2 samples per group for the microRNA arrays in the following four groups: normal control, IGT with renal impairment, diabetes, diabetic kidney disease. In IGT renal impairment group, we have found that the expression of two microRNAs were changed. more...
#> 341                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             Pathologic retinal neovascularization is a potentially blinding consequence seen in many common diseases including diabetic retinopathy, retinopathy of prematurity, and retinal vascular occlusive diseases, among others. The use of therapeutics targeting pro-angiogenesis factors such as vascular endothelial growth factor (VEGF) has proven to be highly effective, however considerable side effects exist and serial anti-VEGF treatment has been shown to decrease effectiveness over time. more...
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