Abstracts

The P53-Induced RNA-Binding Protein ZMAT3 Is a Splicing Regulator That Inhibits the Splicing of Oncogenic CD44 Variants in Colorectal Carcinoma

Presenter: Bruna Muys

A Small Protein Encoded by a Putative LncRNA Regulates Apoptosis and Tumorigenicity in Human Colorectal Cancer Cells

Presenter: Xiao ling Li

A Circular RNA From the MDM2 Locus Controls Cell Cycle Progression by Suppressing P53 Levels

Presenter: Ioannis Grammatikakis

Increased Leukemic Epigenetic Plasticity and Pre-Treatment T-Cell Activation Predict Resistance to CD19 CAR T Cell Therapy in Pediatric Acute Lymphoblastic Leukemia

Presenter: Katherine E. Masih

Immunogenomic Approaches to Optimize Immunotherapeutic Targeting of Neuroblastoma

Presenter: Meijie Tian

Combined Immunogenomic and Immunopeptidomic Analyses Identified Biologically Relevant Immune Signatures and Novel Immunotherapy Targets in Osteosarcoma

Presenter: David Milewski

Identification of a First-in-Class KDM3B Inhibitor That Suppresses PAX3-FOXO1 Oncogene Activity in Fusion Positive Rhabdomyosarcoma

Presenter: Yong Yean Kim

Genetic Counseling Strategies for Patients With a Germline Variant Downgraded to Uncertain Significance, Likely Benign or Benign Following Risk-Reducing Surgery

Presenter: Yi Liu

Association Between CDH1 Pathogenic and Likely Pathogenic Variants, Orofacial Cleft, and Cancer History

Presenter: Anna Duemler

Broadening Our Knowledge of the BAP1 Tumor Predisposition Syndrome

Presenter: Alexandra Lebensohn

Prospective CfDNA Screening for Patient Recruitment of HPV-Targeted TCR Cancer Therapy Clinical Trial

Presenter: Zhigang Kang

R-Loops at Centromeric Chromatin Contribute to Defects in Kinetochore Integrity and Chromosomal Instability

Presenter: Prashant K. Mishra

Cdc48/Ufd1/Npl4 Segregase Regulates Removal of CENP-a/Cse4 From Non-Centromeric Regions to Prevent Chromosomal Instability

Presenter: Kentaro Ohkuni

Determination of the Contribution of EWSR1 to the Phenotype of Ewing Sarcoma Cells via a CRISPR-Mediated Tagging Strategy

Presenter: Soumya Rajan

The RNA and Protein Determinates Governing the HNRNPH1-Dependent Inclusion or Exclusion of EWSR1 Exon 8

Presenter: Katherine Hall

Topoisomerase 2-Related DNA Damage and DNA-PK Inhibition as a Rational Drug Combination for the Treatment of Ewing Sarcoma

Presenter: Katelyn Ludwig

EWS-ETS Fusion Oncoproteins Suppress the Expression of Transcriptional Regulators of Cell Lineage or Differentiation

Presenter: Vernon Justice Ebegboni

LRRC15, a Candidate Immunotherapy Target, Regulates Cell-Cell Interaction, Migration and Spheroid Formation in Osteosarcoma Cells

Presenter: Sanjit Mukherjee

The Expression of Rapidly Degradable ATRX in Osteosarcoma Cells Is a Model System to Observe the Early Molecular Events of ALT Acquisition

Presenter: Nancy Lee

ALT Suppression Requires Localization of ATRX to PML Bodies Downstream of DAXX Binding of Histone H3.3

Presenter: Sarah Clatterbuck Soper

Self-Renewal of Committed Hematopoietic Precursors Leads to Abnormal Hematopoiesis and Myelodysplastic Syndrome

Presenter: Yang Jo Chung

A Novel Mouse Model of Lymphomas/Leukemias: Mini-Chromosome Maintenance (Mcm) 2

Presenter: Toshihiro Matsukawa

The Effects of Acute Lymphoid and Myeloid Leukemia on Wild-Type Hematopoiesis in Mice

Presenter: Ryan Bertoli

Genomic Heterogeneity and Clonal Dynamics of the Evolution of Treatment Resistance and Metastatic Progression in Rectal Cancer

Presenter: Daniela Hirsch

Modeling Chromosome Instability in High-Grade Serous Ovarian Cancer: Minor Instability Permitted by TP53 Loss Is Exacerbated by BRCA1 Mutation

Presenter: Daniel Bronder

TCF7L2 Silencing Results in a LEF1-Driven Feedback Response

Presenter: Markus Brown